Hyperconnectivity of prefrontal cortex to amygdala projections in a mouse model of macrocephaly/autism syndrome
Dysregulation of mTOR signaling has been implicated in autism spectrum disorders. Here authors show that hyperconnectivity and hyperactivity of the mPFC–BLA circuitry inPten+/−mice underlies their social impairments, and that reducing mTORC1 signaling during early postnatal development rescues these...
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| Auteurs principaux: | , , |
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| Format: | article |
| Langue: | EN |
| Publié: |
Nature Portfolio
2016
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| Sujets: | |
| Accès en ligne: | https://doaj.org/article/86a273529d444b7ea9bc1c05d8cddad2 |
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| Résumé: | Dysregulation of mTOR signaling has been implicated in autism spectrum disorders. Here authors show that hyperconnectivity and hyperactivity of the mPFC–BLA circuitry inPten+/−mice underlies their social impairments, and that reducing mTORC1 signaling during early postnatal development rescues these deficits. |
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