Hyperconnectivity of prefrontal cortex to amygdala projections in a mouse model of macrocephaly/autism syndrome

Dysregulation of mTOR signaling has been implicated in autism spectrum disorders. Here authors show that hyperconnectivity and hyperactivity of the mPFC–BLA circuitry inPten+/−mice underlies their social impairments, and that reducing mTORC1 signaling during early postnatal development rescues these...

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Autores principales:	Wen-Chin Huang, Youjun Chen, Damon T. Page
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/86a273529d444b7ea9bc1c05d8cddad2
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spelling	oai:doaj.org-article:86a273529d444b7ea9bc1c05d8cddad22021-12-02T16:58:23ZHyperconnectivity of prefrontal cortex to amygdala projections in a mouse model of macrocephaly/autism syndrome10.1038/ncomms134212041-1723https://doaj.org/article/86a273529d444b7ea9bc1c05d8cddad22016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13421https://doaj.org/toc/2041-1723Dysregulation of mTOR signaling has been implicated in autism spectrum disorders. Here authors show that hyperconnectivity and hyperactivity of the mPFC–BLA circuitry inPten+/−mice underlies their social impairments, and that reducing mTORC1 signaling during early postnatal development rescues these deficits.Wen-Chin HuangYoujun ChenDamon T. PageNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wen-Chin Huang Youjun Chen Damon T. Page Hyperconnectivity of prefrontal cortex to amygdala projections in a mouse model of macrocephaly/autism syndrome
description	Dysregulation of mTOR signaling has been implicated in autism spectrum disorders. Here authors show that hyperconnectivity and hyperactivity of the mPFC–BLA circuitry inPten+/−mice underlies their social impairments, and that reducing mTORC1 signaling during early postnatal development rescues these deficits.
format	article
author	Wen-Chin Huang Youjun Chen Damon T. Page
author_facet	Wen-Chin Huang Youjun Chen Damon T. Page
author_sort	Wen-Chin Huang
title	Hyperconnectivity of prefrontal cortex to amygdala projections in a mouse model of macrocephaly/autism syndrome
title_short	Hyperconnectivity of prefrontal cortex to amygdala projections in a mouse model of macrocephaly/autism syndrome
title_full	Hyperconnectivity of prefrontal cortex to amygdala projections in a mouse model of macrocephaly/autism syndrome
title_fullStr	Hyperconnectivity of prefrontal cortex to amygdala projections in a mouse model of macrocephaly/autism syndrome
title_full_unstemmed	Hyperconnectivity of prefrontal cortex to amygdala projections in a mouse model of macrocephaly/autism syndrome
title_sort	hyperconnectivity of prefrontal cortex to amygdala projections in a mouse model of macrocephaly/autism syndrome
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/86a273529d444b7ea9bc1c05d8cddad2
work_keys_str_mv	AT wenchinhuang hyperconnectivityofprefrontalcortextoamygdalaprojectionsinamousemodelofmacrocephalyautismsyndrome AT youjunchen hyperconnectivityofprefrontalcortextoamygdalaprojectionsinamousemodelofmacrocephalyautismsyndrome AT damontpage hyperconnectivityofprefrontalcortextoamygdalaprojectionsinamousemodelofmacrocephalyautismsyndrome
_version_	1718382340820959232

Hyperconnectivity of prefrontal cortex to amygdala projections in a mouse model of macrocephaly/autism syndrome

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