Cerebral small vessel disease phenotype and 5-year mortality in asymptomatic middle-to-old aged individuals

Cerebral small vessel disease phenotype and 5-year mortality in asymptomatic middle-to-old aged individuals

Abstract The present study aimed to determine whether a recently proposed cerebral small vessel disease (CSVD) classification scheme could differentiate the 5-year all-cause mortality in middle-to-old aged asymptomatic CSVD. Stroke-free and non-demented participants recruited from the community-base...

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Autores principales: Wei-Ju Lee, Kun-Hsien Chou, Pei-Lin Lee, Li-Ning Peng, Pei-Ning Wang, Ching-Po Lin, Liang-Kung Chen, Chih-Ping Chung
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/86a508c220f34e6e82c43f5cb2d6f710
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spelling oai:doaj.org-article:86a508c220f34e6e82c43f5cb2d6f7102021-12-05T12:13:36ZCerebral small vessel disease phenotype and 5-year mortality in asymptomatic middle-to-old aged individuals10.1038/s41598-021-02656-72045-2322https://doaj.org/article/86a508c220f34e6e82c43f5cb2d6f7102021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02656-7https://doaj.org/toc/2045-2322Abstract The present study aimed to determine whether a recently proposed cerebral small vessel disease (CSVD) classification scheme could differentiate the 5-year all-cause mortality in middle-to-old aged asymptomatic CSVD. Stroke-free and non-demented participants recruited from the community-based I-Lan Longitudinal Aging Study underwent baseline brain magnetic resonance imaging (MRI) between 2011 and 2014 and were followed-up between 2018 and 2019. The study population was classified into control (non-CSVD) and CSVD type 1–4 groups based on MRI markers. We determined the association with mortality using Cox regression models, adjusting for the age, sex, and vascular risk factors. A total of 735 participants were included. During a mean follow-up of 5.7 years, 62 (8.4%) died. There were 335 CSVD type 1 (57.9 ± 5.9 years), 249 type 2 (65.6 ± 8.1 years), 52 type 3 (67.8 ± 9.2 years), and 38 type 4 (64.3 ± 9.0 years). Among the four CSVD types, CSVD type 4 individuals had significantly higher all-cause mortality (adjusted hazard ratio = 5.0, 95% confidence interval 1.6–15.3) compared to controls. This novel MRI-based CSVD classification scheme was able to identify individuals at risk of mortality at an asymptomatic, early stage of disease and might be applied for future community-based health research and policy.Wei-Ju LeeKun-Hsien ChouPei-Lin LeeLi-Ning PengPei-Ning WangChing-Po LinLiang-Kung ChenChih-Ping ChungNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Wei-Ju Lee
Kun-Hsien Chou
Pei-Lin Lee
Li-Ning Peng
Pei-Ning Wang
Ching-Po Lin
Liang-Kung Chen
Chih-Ping Chung
Cerebral small vessel disease phenotype and 5-year mortality in asymptomatic middle-to-old aged individuals
description Abstract The present study aimed to determine whether a recently proposed cerebral small vessel disease (CSVD) classification scheme could differentiate the 5-year all-cause mortality in middle-to-old aged asymptomatic CSVD. Stroke-free and non-demented participants recruited from the community-based I-Lan Longitudinal Aging Study underwent baseline brain magnetic resonance imaging (MRI) between 2011 and 2014 and were followed-up between 2018 and 2019. The study population was classified into control (non-CSVD) and CSVD type 1–4 groups based on MRI markers. We determined the association with mortality using Cox regression models, adjusting for the age, sex, and vascular risk factors. A total of 735 participants were included. During a mean follow-up of 5.7 years, 62 (8.4%) died. There were 335 CSVD type 1 (57.9 ± 5.9 years), 249 type 2 (65.6 ± 8.1 years), 52 type 3 (67.8 ± 9.2 years), and 38 type 4 (64.3 ± 9.0 years). Among the four CSVD types, CSVD type 4 individuals had significantly higher all-cause mortality (adjusted hazard ratio = 5.0, 95% confidence interval 1.6–15.3) compared to controls. This novel MRI-based CSVD classification scheme was able to identify individuals at risk of mortality at an asymptomatic, early stage of disease and might be applied for future community-based health research and policy.
format article
author Wei-Ju Lee
Kun-Hsien Chou
Pei-Lin Lee
Li-Ning Peng
Pei-Ning Wang
Ching-Po Lin
Liang-Kung Chen
Chih-Ping Chung
author_facet Wei-Ju Lee
Kun-Hsien Chou
Pei-Lin Lee
Li-Ning Peng
Pei-Ning Wang
Ching-Po Lin
Liang-Kung Chen
Chih-Ping Chung
author_sort Wei-Ju Lee
title Cerebral small vessel disease phenotype and 5-year mortality in asymptomatic middle-to-old aged individuals
title_short Cerebral small vessel disease phenotype and 5-year mortality in asymptomatic middle-to-old aged individuals
title_full Cerebral small vessel disease phenotype and 5-year mortality in asymptomatic middle-to-old aged individuals
title_fullStr Cerebral small vessel disease phenotype and 5-year mortality in asymptomatic middle-to-old aged individuals
title_full_unstemmed Cerebral small vessel disease phenotype and 5-year mortality in asymptomatic middle-to-old aged individuals
title_sort cerebral small vessel disease phenotype and 5-year mortality in asymptomatic middle-to-old aged individuals
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/86a508c220f34e6e82c43f5cb2d6f710
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