FcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity

Neutrophils are versatile immune cells that may also serve as antigen-presenting cells (APC). Here the authors show that engaging FcγRs on neutrophils with immune complexes or an anti-FcγR-antigen conjugate induces neutrophil APC with comparable functions as classical dendritic cells, and with thera...

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Autores principales:	Vijayashree Mysore, Xavier Cullere, Joseph Mears, Florencia Rosetti, Koshu Okubo, Pei X. Liew, Fan Zhang, Iris Madera-Salcedo, Frank Rosenbauer, Richard M. Stone, Jon C. Aster, Ulrich H. von Andrian, Andrew H. Lichtman, Soumya Raychaudhuri, Tanya N. Mayadas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/86a5a1c6c18f436081a1927c18c8de2d
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spelling	oai:doaj.org-article:86a5a1c6c18f436081a1927c18c8de2d2021-12-02T15:07:49ZFcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity10.1038/s41467-021-24591-x2041-1723https://doaj.org/article/86a5a1c6c18f436081a1927c18c8de2d2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24591-xhttps://doaj.org/toc/2041-1723Neutrophils are versatile immune cells that may also serve as antigen-presenting cells (APC). Here the authors show that engaging FcγRs on neutrophils with immune complexes or an anti-FcγR-antigen conjugate induces neutrophil APC with comparable functions as classical dendritic cells, and with therapeutic potentials for cancer and infectious diseases.Vijayashree MysoreXavier CullereJoseph MearsFlorencia RosettiKoshu OkuboPei X. LiewFan ZhangIris Madera-SalcedoFrank RosenbauerRichard M. StoneJon C. AsterUlrich H. von AndrianAndrew H. LichtmanSoumya RaychaudhuriTanya N. MayadasNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-23 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Vijayashree Mysore Xavier Cullere Joseph Mears Florencia Rosetti Koshu Okubo Pei X. Liew Fan Zhang Iris Madera-Salcedo Frank Rosenbauer Richard M. Stone Jon C. Aster Ulrich H. von Andrian Andrew H. Lichtman Soumya Raychaudhuri Tanya N. Mayadas FcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity
description	Neutrophils are versatile immune cells that may also serve as antigen-presenting cells (APC). Here the authors show that engaging FcγRs on neutrophils with immune complexes or an anti-FcγR-antigen conjugate induces neutrophil APC with comparable functions as classical dendritic cells, and with therapeutic potentials for cancer and infectious diseases.
format	article
author	Vijayashree Mysore Xavier Cullere Joseph Mears Florencia Rosetti Koshu Okubo Pei X. Liew Fan Zhang Iris Madera-Salcedo Frank Rosenbauer Richard M. Stone Jon C. Aster Ulrich H. von Andrian Andrew H. Lichtman Soumya Raychaudhuri Tanya N. Mayadas
author_facet	Vijayashree Mysore Xavier Cullere Joseph Mears Florencia Rosetti Koshu Okubo Pei X. Liew Fan Zhang Iris Madera-Salcedo Frank Rosenbauer Richard M. Stone Jon C. Aster Ulrich H. von Andrian Andrew H. Lichtman Soumya Raychaudhuri Tanya N. Mayadas
author_sort	Vijayashree Mysore
title	FcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity
title_short	FcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity
title_full	FcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity
title_fullStr	FcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity
title_full_unstemmed	FcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity
title_sort	fcγr engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/86a5a1c6c18f436081a1927c18c8de2d
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FcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity

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