ICP22/IE63 Mediated Transcriptional Regulation and Immune Evasion: Two Important Survival Strategies for Alphaherpesviruses
In the process of infecting the host, alphaherpesviruses have derived a series of adaptation and survival strategies, such as latent infection, autophagy and immune evasion, to survive in the host environment. Infected cell protein 22 (ICP22) or its homologue immediate early protein 63 (IE63) is a p...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Frontiers Media S.A.
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/86a74be869d5487da9c6b8bc44ba8f65 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:86a74be869d5487da9c6b8bc44ba8f65 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:86a74be869d5487da9c6b8bc44ba8f652021-12-02T10:18:24ZICP22/IE63 Mediated Transcriptional Regulation and Immune Evasion: Two Important Survival Strategies for Alphaherpesviruses1664-322410.3389/fimmu.2021.743466https://doaj.org/article/86a74be869d5487da9c6b8bc44ba8f652021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.743466/fullhttps://doaj.org/toc/1664-3224In the process of infecting the host, alphaherpesviruses have derived a series of adaptation and survival strategies, such as latent infection, autophagy and immune evasion, to survive in the host environment. Infected cell protein 22 (ICP22) or its homologue immediate early protein 63 (IE63) is a posttranslationally modified multifunctional viral regulatory protein encoded by all alphaherpesviruses. In addition to playing an important role in the efficient use of host cell RNA polymerase II, it also plays an important role in the defense process of the virus overcoming the host immune system. These two effects of ICP22/IE63 are important survival strategies for alphaherpesviruses. In this review, we summarize the complex mechanism by which the ICP22 protein regulates the transcription of alphaherpesviruses and their host genes and the mechanism by which ICP22/IE63 participates in immune escape. Reviewing these mechanisms will also help us understand the pathogenesis of alphaherpesvirus infections and provide new strategies to combat these viral infections.Qing HeQing HeQing HeYing WuYing WuYing WuMingshu WangMingshu WangMingshu WangShun ChenShun ChenShun ChenRenyong JiaRenyong JiaRenyong JiaQiao YangQiao YangQiao YangDekang ZhuDekang ZhuMafeng LiuMafeng LiuMafeng LiuXinxin ZhaoXinxin ZhaoXinxin ZhaoShaqiu ZhangShaqiu ZhangShaqiu ZhangJuan HuangJuan HuangJuan HuangXumin OuXumin OuXumin OuSai MaoSai MaoSai MaoQun GaoQun GaoQun GaoDi SunDi SunDi SunBin TianBin TianBin TianAnchun ChengAnchun ChengAnchun ChengFrontiers Media S.A.articlealphaherpesvirusesICP22/IE63RNA polymerase Pol IIimmune evasionantiviral responseImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
alphaherpesviruses ICP22/IE63 RNA polymerase Pol II immune evasion antiviral response Immunologic diseases. Allergy RC581-607 |
| spellingShingle |
alphaherpesviruses ICP22/IE63 RNA polymerase Pol II immune evasion antiviral response Immunologic diseases. Allergy RC581-607 Qing He Qing He Qing He Ying Wu Ying Wu Ying Wu Mingshu Wang Mingshu Wang Mingshu Wang Shun Chen Shun Chen Shun Chen Renyong Jia Renyong Jia Renyong Jia Qiao Yang Qiao Yang Qiao Yang Dekang Zhu Dekang Zhu Mafeng Liu Mafeng Liu Mafeng Liu Xinxin Zhao Xinxin Zhao Xinxin Zhao Shaqiu Zhang Shaqiu Zhang Shaqiu Zhang Juan Huang Juan Huang Juan Huang Xumin Ou Xumin Ou Xumin Ou Sai Mao Sai Mao Sai Mao Qun Gao Qun Gao Qun Gao Di Sun Di Sun Di Sun Bin Tian Bin Tian Bin Tian Anchun Cheng Anchun Cheng Anchun Cheng ICP22/IE63 Mediated Transcriptional Regulation and Immune Evasion: Two Important Survival Strategies for Alphaherpesviruses |
| description |
In the process of infecting the host, alphaherpesviruses have derived a series of adaptation and survival strategies, such as latent infection, autophagy and immune evasion, to survive in the host environment. Infected cell protein 22 (ICP22) or its homologue immediate early protein 63 (IE63) is a posttranslationally modified multifunctional viral regulatory protein encoded by all alphaherpesviruses. In addition to playing an important role in the efficient use of host cell RNA polymerase II, it also plays an important role in the defense process of the virus overcoming the host immune system. These two effects of ICP22/IE63 are important survival strategies for alphaherpesviruses. In this review, we summarize the complex mechanism by which the ICP22 protein regulates the transcription of alphaherpesviruses and their host genes and the mechanism by which ICP22/IE63 participates in immune escape. Reviewing these mechanisms will also help us understand the pathogenesis of alphaherpesvirus infections and provide new strategies to combat these viral infections. |
| format |
article |
| author |
Qing He Qing He Qing He Ying Wu Ying Wu Ying Wu Mingshu Wang Mingshu Wang Mingshu Wang Shun Chen Shun Chen Shun Chen Renyong Jia Renyong Jia Renyong Jia Qiao Yang Qiao Yang Qiao Yang Dekang Zhu Dekang Zhu Mafeng Liu Mafeng Liu Mafeng Liu Xinxin Zhao Xinxin Zhao Xinxin Zhao Shaqiu Zhang Shaqiu Zhang Shaqiu Zhang Juan Huang Juan Huang Juan Huang Xumin Ou Xumin Ou Xumin Ou Sai Mao Sai Mao Sai Mao Qun Gao Qun Gao Qun Gao Di Sun Di Sun Di Sun Bin Tian Bin Tian Bin Tian Anchun Cheng Anchun Cheng Anchun Cheng |
| author_facet |
Qing He Qing He Qing He Ying Wu Ying Wu Ying Wu Mingshu Wang Mingshu Wang Mingshu Wang Shun Chen Shun Chen Shun Chen Renyong Jia Renyong Jia Renyong Jia Qiao Yang Qiao Yang Qiao Yang Dekang Zhu Dekang Zhu Mafeng Liu Mafeng Liu Mafeng Liu Xinxin Zhao Xinxin Zhao Xinxin Zhao Shaqiu Zhang Shaqiu Zhang Shaqiu Zhang Juan Huang Juan Huang Juan Huang Xumin Ou Xumin Ou Xumin Ou Sai Mao Sai Mao Sai Mao Qun Gao Qun Gao Qun Gao Di Sun Di Sun Di Sun Bin Tian Bin Tian Bin Tian Anchun Cheng Anchun Cheng Anchun Cheng |
| author_sort |
Qing He |
| title |
ICP22/IE63 Mediated Transcriptional Regulation and Immune Evasion: Two Important Survival Strategies for Alphaherpesviruses |
| title_short |
ICP22/IE63 Mediated Transcriptional Regulation and Immune Evasion: Two Important Survival Strategies for Alphaherpesviruses |
| title_full |
ICP22/IE63 Mediated Transcriptional Regulation and Immune Evasion: Two Important Survival Strategies for Alphaherpesviruses |
| title_fullStr |
ICP22/IE63 Mediated Transcriptional Regulation and Immune Evasion: Two Important Survival Strategies for Alphaherpesviruses |
| title_full_unstemmed |
ICP22/IE63 Mediated Transcriptional Regulation and Immune Evasion: Two Important Survival Strategies for Alphaherpesviruses |
| title_sort |
icp22/ie63 mediated transcriptional regulation and immune evasion: two important survival strategies for alphaherpesviruses |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/86a74be869d5487da9c6b8bc44ba8f65 |
| work_keys_str_mv |
AT qinghe icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT qinghe icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT qinghe icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT yingwu icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT yingwu icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT yingwu icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT mingshuwang icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT mingshuwang icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT mingshuwang icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT shunchen icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT shunchen icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT shunchen icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT renyongjia icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT renyongjia icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT renyongjia icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT qiaoyang icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT qiaoyang icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT qiaoyang icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT dekangzhu icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT dekangzhu icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT mafengliu icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT mafengliu icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT mafengliu icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT xinxinzhao icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT xinxinzhao icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT xinxinzhao icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT shaqiuzhang icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT shaqiuzhang icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT shaqiuzhang icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT juanhuang icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT juanhuang icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT juanhuang icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT xuminou icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT xuminou icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT xuminou icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT saimao icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT saimao icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT saimao icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT qungao icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT qungao icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT qungao icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT disun icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT disun icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT disun icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT bintian icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT bintian icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT bintian icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT anchuncheng icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT anchuncheng icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses AT anchuncheng icp22ie63mediatedtranscriptionalregulationandimmuneevasiontwoimportantsurvivalstrategiesforalphaherpesviruses |
| _version_ |
1718397419824087040 |