mTORC2 signalling regulates M2 macrophage differentiation in response to helminth infection and adaptive thermogenesis

mTORC1 and mTORC2 are alternatively required for differentiation of T cells into Th1/Th17 or Th2 cells. Here the authors show mTORC2 signalling is also needed for IL-4-induced M2 activation with functional evidence provided by aN. brasiliensisinfection model and cold challenge to model adaptive ther...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	R. W. Hallowell, S. L. Collins, J. M. Craig, Y. Zhang, M. Oh, P. B. Illei, Y. Chan-Li, C. L. Vigeland, W. Mitzner, A. L. Scott, J. D. Powell, M. R. Horton
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/86aafa4460cc457cab9b0df47df8cc19
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:86aafa4460cc457cab9b0df47df8cc19
record_format	dspace
spelling	oai:doaj.org-article:86aafa4460cc457cab9b0df47df8cc192021-12-02T14:42:05ZmTORC2 signalling regulates M2 macrophage differentiation in response to helminth infection and adaptive thermogenesis10.1038/ncomms142082041-1723https://doaj.org/article/86aafa4460cc457cab9b0df47df8cc192017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14208https://doaj.org/toc/2041-1723mTORC1 and mTORC2 are alternatively required for differentiation of T cells into Th1/Th17 or Th2 cells. Here the authors show mTORC2 signalling is also needed for IL-4-induced M2 activation with functional evidence provided by aN. brasiliensisinfection model and cold challenge to model adaptive thermogenesis.R. W. HallowellS. L. CollinsJ. M. CraigY. ZhangM. OhP. B. IlleiY. Chan-LiC. L. VigelandW. MitznerA. L. ScottJ. D. PowellM. R. HortonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q R. W. Hallowell S. L. Collins J. M. Craig Y. Zhang M. Oh P. B. Illei Y. Chan-Li C. L. Vigeland W. Mitzner A. L. Scott J. D. Powell M. R. Horton mTORC2 signalling regulates M2 macrophage differentiation in response to helminth infection and adaptive thermogenesis
description	mTORC1 and mTORC2 are alternatively required for differentiation of T cells into Th1/Th17 or Th2 cells. Here the authors show mTORC2 signalling is also needed for IL-4-induced M2 activation with functional evidence provided by aN. brasiliensisinfection model and cold challenge to model adaptive thermogenesis.
format	article
author	R. W. Hallowell S. L. Collins J. M. Craig Y. Zhang M. Oh P. B. Illei Y. Chan-Li C. L. Vigeland W. Mitzner A. L. Scott J. D. Powell M. R. Horton
author_facet	R. W. Hallowell S. L. Collins J. M. Craig Y. Zhang M. Oh P. B. Illei Y. Chan-Li C. L. Vigeland W. Mitzner A. L. Scott J. D. Powell M. R. Horton
author_sort	R. W. Hallowell
title	mTORC2 signalling regulates M2 macrophage differentiation in response to helminth infection and adaptive thermogenesis
title_short	mTORC2 signalling regulates M2 macrophage differentiation in response to helminth infection and adaptive thermogenesis
title_full	mTORC2 signalling regulates M2 macrophage differentiation in response to helminth infection and adaptive thermogenesis
title_fullStr	mTORC2 signalling regulates M2 macrophage differentiation in response to helminth infection and adaptive thermogenesis
title_full_unstemmed	mTORC2 signalling regulates M2 macrophage differentiation in response to helminth infection and adaptive thermogenesis
title_sort	mtorc2 signalling regulates m2 macrophage differentiation in response to helminth infection and adaptive thermogenesis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/86aafa4460cc457cab9b0df47df8cc19
work_keys_str_mv	AT rwhallowell mtorc2signallingregulatesm2macrophagedifferentiationinresponsetohelminthinfectionandadaptivethermogenesis AT slcollins mtorc2signallingregulatesm2macrophagedifferentiationinresponsetohelminthinfectionandadaptivethermogenesis AT jmcraig mtorc2signallingregulatesm2macrophagedifferentiationinresponsetohelminthinfectionandadaptivethermogenesis AT yzhang mtorc2signallingregulatesm2macrophagedifferentiationinresponsetohelminthinfectionandadaptivethermogenesis AT moh mtorc2signallingregulatesm2macrophagedifferentiationinresponsetohelminthinfectionandadaptivethermogenesis AT pbillei mtorc2signallingregulatesm2macrophagedifferentiationinresponsetohelminthinfectionandadaptivethermogenesis AT ychanli mtorc2signallingregulatesm2macrophagedifferentiationinresponsetohelminthinfectionandadaptivethermogenesis AT clvigeland mtorc2signallingregulatesm2macrophagedifferentiationinresponsetohelminthinfectionandadaptivethermogenesis AT wmitzner mtorc2signallingregulatesm2macrophagedifferentiationinresponsetohelminthinfectionandadaptivethermogenesis AT alscott mtorc2signallingregulatesm2macrophagedifferentiationinresponsetohelminthinfectionandadaptivethermogenesis AT jdpowell mtorc2signallingregulatesm2macrophagedifferentiationinresponsetohelminthinfectionandadaptivethermogenesis AT mrhorton mtorc2signallingregulatesm2macrophagedifferentiationinresponsetohelminthinfectionandadaptivethermogenesis
_version_	1718389820540059648

mTORC2 signalling regulates M2 macrophage differentiation in response to helminth infection and adaptive thermogenesis

Ejemplares similares