mTORC2 signalling regulates M2 macrophage differentiation in response to helminth infection and adaptive thermogenesis

mTORC2 signalling regulates M2 macrophage differentiation in response to helminth infection and adaptive thermogenesis

mTORC1 and mTORC2 are alternatively required for differentiation of T cells into Th1/Th17 or Th2 cells. Here the authors show mTORC2 signalling is also needed for IL-4-induced M2 activation with functional evidence provided by aN. brasiliensisinfection model and cold challenge to model adaptive ther...

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Autores principales: R. W. Hallowell, S. L. Collins, J. M. Craig, Y. Zhang, M. Oh, P. B. Illei, Y. Chan-Li, C. L. Vigeland, W. Mitzner, A. L. Scott, J. D. Powell, M. R. Horton
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/86aafa4460cc457cab9b0df47df8cc19
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