Peptide VSAK maintains tissue glucose uptake and attenuates pro-inflammatory responses caused by LPS in an experimental model of the systemic inflammatory response syndrome: a PET study

Abstract The present investigation using Positron Emission Tomography shows how peptide VSAK can reduce the detrimental effects produced by lipopolysaccharides in Dutch dwarf rabbits, used to develop the Systemic Inflammatory Response Syndrome (SIRS). Animals concomitantly treated with lipopolysacch...

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Autores principales:	Ismael Luna-Reyes, Eréndira G. Pérez-Hernández, Blanca Delgado-Coello, Miguel Ángel Ávila-Rodríguez, Jaime Mas-Oliva
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/86adab916c2243f5b60d761a293bf07c
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spelling	oai:doaj.org-article:86adab916c2243f5b60d761a293bf07c2021-12-02T17:55:09ZPeptide VSAK maintains tissue glucose uptake and attenuates pro-inflammatory responses caused by LPS in an experimental model of the systemic inflammatory response syndrome: a PET study10.1038/s41598-021-94224-22045-2322https://doaj.org/article/86adab916c2243f5b60d761a293bf07c2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94224-2https://doaj.org/toc/2045-2322Abstract The present investigation using Positron Emission Tomography shows how peptide VSAK can reduce the detrimental effects produced by lipopolysaccharides in Dutch dwarf rabbits, used to develop the Systemic Inflammatory Response Syndrome (SIRS). Animals concomitantly treated with lipopolysaccharides (LPS) and peptide VSAK show important protection in the loss of radiolabeled-glucose uptake observed in diverse organs when animals are exclusively treated with LPS. Treatment with peptide VSAK prevented the onset of changes in serum levels of glucose and insulin associated with the establishment of SIRS and the insulin resistance-like syndrome. Treatment with peptide VSAK also allowed an important attenuation in the circulating levels of pro-inflammatory molecules in LPS-treated animals. As a whole, our data suggest that peptide VSAK might be considered as a candidate in the development of new therapeutic possibilities focused on mitigating the harmful effects produced by lipopolysaccharides during the course of SIRS.Ismael Luna-ReyesEréndira G. Pérez-HernándezBlanca Delgado-CoelloMiguel Ángel Ávila-RodríguezJaime Mas-OlivaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ismael Luna-Reyes Eréndira G. Pérez-Hernández Blanca Delgado-Coello Miguel Ángel Ávila-Rodríguez Jaime Mas-Oliva Peptide VSAK maintains tissue glucose uptake and attenuates pro-inflammatory responses caused by LPS in an experimental model of the systemic inflammatory response syndrome: a PET study
description	Abstract The present investigation using Positron Emission Tomography shows how peptide VSAK can reduce the detrimental effects produced by lipopolysaccharides in Dutch dwarf rabbits, used to develop the Systemic Inflammatory Response Syndrome (SIRS). Animals concomitantly treated with lipopolysaccharides (LPS) and peptide VSAK show important protection in the loss of radiolabeled-glucose uptake observed in diverse organs when animals are exclusively treated with LPS. Treatment with peptide VSAK prevented the onset of changes in serum levels of glucose and insulin associated with the establishment of SIRS and the insulin resistance-like syndrome. Treatment with peptide VSAK also allowed an important attenuation in the circulating levels of pro-inflammatory molecules in LPS-treated animals. As a whole, our data suggest that peptide VSAK might be considered as a candidate in the development of new therapeutic possibilities focused on mitigating the harmful effects produced by lipopolysaccharides during the course of SIRS.
format	article
author	Ismael Luna-Reyes Eréndira G. Pérez-Hernández Blanca Delgado-Coello Miguel Ángel Ávila-Rodríguez Jaime Mas-Oliva
author_facet	Ismael Luna-Reyes Eréndira G. Pérez-Hernández Blanca Delgado-Coello Miguel Ángel Ávila-Rodríguez Jaime Mas-Oliva
author_sort	Ismael Luna-Reyes
title	Peptide VSAK maintains tissue glucose uptake and attenuates pro-inflammatory responses caused by LPS in an experimental model of the systemic inflammatory response syndrome: a PET study
title_short	Peptide VSAK maintains tissue glucose uptake and attenuates pro-inflammatory responses caused by LPS in an experimental model of the systemic inflammatory response syndrome: a PET study
title_full	Peptide VSAK maintains tissue glucose uptake and attenuates pro-inflammatory responses caused by LPS in an experimental model of the systemic inflammatory response syndrome: a PET study
title_fullStr	Peptide VSAK maintains tissue glucose uptake and attenuates pro-inflammatory responses caused by LPS in an experimental model of the systemic inflammatory response syndrome: a PET study
title_full_unstemmed	Peptide VSAK maintains tissue glucose uptake and attenuates pro-inflammatory responses caused by LPS in an experimental model of the systemic inflammatory response syndrome: a PET study
title_sort	peptide vsak maintains tissue glucose uptake and attenuates pro-inflammatory responses caused by lps in an experimental model of the systemic inflammatory response syndrome: a pet study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/86adab916c2243f5b60d761a293bf07c
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Peptide VSAK maintains tissue glucose uptake and attenuates pro-inflammatory responses caused by LPS in an experimental model of the systemic inflammatory response syndrome: a PET study

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