Novel Concepts for HIV Vaccine Vector Design

ABSTRACT The unprecedented challenges of developing effective vaccines against intracellular pathogens such as HIV, malaria, and tuberculosis have resulted in more rational approaches to vaccine development. Apart from the recent advances in the design and selection of improved epitopes and adjuvant...

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Autores principales:	Quazim A. Alayo, Nicholas M. Provine, Pablo Penaloza-MacMaster
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2017
Materias:	T cells antibodies human immunodeficiency virus vaccines Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/86ae457b7c2a4e41827f2883f294eda3
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spelling	oai:doaj.org-article:86ae457b7c2a4e41827f2883f294eda32021-11-15T15:21:53ZNovel Concepts for HIV Vaccine Vector Design10.1128/mSphere.00415-172379-5042https://doaj.org/article/86ae457b7c2a4e41827f2883f294eda32017-12-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00415-17https://doaj.org/toc/2379-5042ABSTRACT The unprecedented challenges of developing effective vaccines against intracellular pathogens such as HIV, malaria, and tuberculosis have resulted in more rational approaches to vaccine development. Apart from the recent advances in the design and selection of improved epitopes and adjuvants, there are also ongoing efforts to optimize delivery platforms. Viral vectors are the best-characterized delivery tools because of their intrinsic adjuvant capability, unique cellular tropism, and ability to trigger robust adaptive immune responses. However, a known limitation of viral vectors is preexisting immunity, and ongoing efforts are aimed at developing novel vector platforms with lower seroprevalence. It is also becoming increasingly clear that different vectors, even those derived from phylogenetically similar viruses, can elicit substantially distinct immune responses, in terms of quantity, quality, and location, which can ultimately affect immune protection. This review provides a summary of the status of viral vector development for HIV vaccines, with a particular focus on novel viral vectors and the types of adaptive immune responses that they induce.Quazim A. AlayoNicholas M. ProvinePablo Penaloza-MacMasterAmerican Society for MicrobiologyarticleT cellsantibodieshuman immunodeficiency virusvaccinesMicrobiologyQR1-502ENmSphere, Vol 2, Iss 6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	T cells antibodies human immunodeficiency virus vaccines Microbiology QR1-502
spellingShingle	T cells antibodies human immunodeficiency virus vaccines Microbiology QR1-502 Quazim A. Alayo Nicholas M. Provine Pablo Penaloza-MacMaster Novel Concepts for HIV Vaccine Vector Design
description	ABSTRACT The unprecedented challenges of developing effective vaccines against intracellular pathogens such as HIV, malaria, and tuberculosis have resulted in more rational approaches to vaccine development. Apart from the recent advances in the design and selection of improved epitopes and adjuvants, there are also ongoing efforts to optimize delivery platforms. Viral vectors are the best-characterized delivery tools because of their intrinsic adjuvant capability, unique cellular tropism, and ability to trigger robust adaptive immune responses. However, a known limitation of viral vectors is preexisting immunity, and ongoing efforts are aimed at developing novel vector platforms with lower seroprevalence. It is also becoming increasingly clear that different vectors, even those derived from phylogenetically similar viruses, can elicit substantially distinct immune responses, in terms of quantity, quality, and location, which can ultimately affect immune protection. This review provides a summary of the status of viral vector development for HIV vaccines, with a particular focus on novel viral vectors and the types of adaptive immune responses that they induce.
format	article
author	Quazim A. Alayo Nicholas M. Provine Pablo Penaloza-MacMaster
author_facet	Quazim A. Alayo Nicholas M. Provine Pablo Penaloza-MacMaster
author_sort	Quazim A. Alayo
title	Novel Concepts for HIV Vaccine Vector Design
title_short	Novel Concepts for HIV Vaccine Vector Design
title_full	Novel Concepts for HIV Vaccine Vector Design
title_fullStr	Novel Concepts for HIV Vaccine Vector Design
title_full_unstemmed	Novel Concepts for HIV Vaccine Vector Design
title_sort	novel concepts for hiv vaccine vector design
publisher	American Society for Microbiology
publishDate	2017
url	https://doaj.org/article/86ae457b7c2a4e41827f2883f294eda3
work_keys_str_mv	AT quazimaalayo novelconceptsforhivvaccinevectordesign AT nicholasmprovine novelconceptsforhivvaccinevectordesign AT pablopenalozamacmaster novelconceptsforhivvaccinevectordesign
_version_	1718428081534795776

Novel Concepts for HIV Vaccine Vector Design

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