Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures

Neurodegeneration is increasingly associated with endolysosomal and autophagy dysfunction. Here, Miranda and colleagues show that disruption of neuronal PI3P/Vps34 signaling leads to endolysosomal membrane damage and aberrant release of undigested material in APP-CTF- and BMP-positive exosomes.

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Autores principales:	André M. Miranda, Zofia M. Lasiecka, Yimeng Xu, Jessi Neufeld, Sanjid Shahriar, Sabrina Simoes, Robin B. Chan, Tiago Gil Oliveira, Scott A. Small, Gilbert Di Paolo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/86b0425ec6574642a7fb5c502f85d7c0
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spelling	oai:doaj.org-article:86b0425ec6574642a7fb5c502f85d7c02021-12-02T14:40:08ZNeuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures10.1038/s41467-017-02533-w2041-1723https://doaj.org/article/86b0425ec6574642a7fb5c502f85d7c02018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02533-whttps://doaj.org/toc/2041-1723Neurodegeneration is increasingly associated with endolysosomal and autophagy dysfunction. Here, Miranda and colleagues show that disruption of neuronal PI3P/Vps34 signaling leads to endolysosomal membrane damage and aberrant release of undigested material in APP-CTF- and BMP-positive exosomes.André M. MirandaZofia M. LasieckaYimeng XuJessi NeufeldSanjid ShahriarSabrina SimoesRobin B. ChanTiago Gil OliveiraScott A. SmallGilbert Di PaoloNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q André M. Miranda Zofia M. Lasiecka Yimeng Xu Jessi Neufeld Sanjid Shahriar Sabrina Simoes Robin B. Chan Tiago Gil Oliveira Scott A. Small Gilbert Di Paolo Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures
description	Neurodegeneration is increasingly associated with endolysosomal and autophagy dysfunction. Here, Miranda and colleagues show that disruption of neuronal PI3P/Vps34 signaling leads to endolysosomal membrane damage and aberrant release of undigested material in APP-CTF- and BMP-positive exosomes.
format	article
author	André M. Miranda Zofia M. Lasiecka Yimeng Xu Jessi Neufeld Sanjid Shahriar Sabrina Simoes Robin B. Chan Tiago Gil Oliveira Scott A. Small Gilbert Di Paolo
author_facet	André M. Miranda Zofia M. Lasiecka Yimeng Xu Jessi Neufeld Sanjid Shahriar Sabrina Simoes Robin B. Chan Tiago Gil Oliveira Scott A. Small Gilbert Di Paolo
author_sort	André M. Miranda
title	Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures
title_short	Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures
title_full	Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures
title_fullStr	Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures
title_full_unstemmed	Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures
title_sort	neuronal lysosomal dysfunction releases exosomes harboring app c-terminal fragments and unique lipid signatures
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/86b0425ec6574642a7fb5c502f85d7c0
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Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures

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