Phosphorylation of conserved phosphoinositide binding pocket regulates sorting nexin membrane targeting

Sorting nexin 3 (SNX3) is a phosphatidylinositol 3-phosphate binding protein that localizes to early endosomes. Here the authors use NMR to resolve SNX3′s membrane interactions, revealing that membrane binding is regulated through phosphorylation of a conserved serine by its lipid recognition site....

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Autores principales:	Marc Lenoir, Cansel Ustunel, Sandya Rajesh, Jaswant Kaur, Dimitri Moreau, Jean Gruenberg, Michael Overduin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/86b2c9b181b3493589dd4feb5d76f8d4
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spelling	oai:doaj.org-article:86b2c9b181b3493589dd4feb5d76f8d42021-12-02T15:34:21ZPhosphorylation of conserved phosphoinositide binding pocket regulates sorting nexin membrane targeting10.1038/s41467-018-03370-12041-1723https://doaj.org/article/86b2c9b181b3493589dd4feb5d76f8d42018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03370-1https://doaj.org/toc/2041-1723Sorting nexin 3 (SNX3) is a phosphatidylinositol 3-phosphate binding protein that localizes to early endosomes. Here the authors use NMR to resolve SNX3′s membrane interactions, revealing that membrane binding is regulated through phosphorylation of a conserved serine by its lipid recognition site.Marc LenoirCansel UstunelSandya RajeshJaswant KaurDimitri MoreauJean GruenbergMichael OverduinNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marc Lenoir Cansel Ustunel Sandya Rajesh Jaswant Kaur Dimitri Moreau Jean Gruenberg Michael Overduin Phosphorylation of conserved phosphoinositide binding pocket regulates sorting nexin membrane targeting
description	Sorting nexin 3 (SNX3) is a phosphatidylinositol 3-phosphate binding protein that localizes to early endosomes. Here the authors use NMR to resolve SNX3′s membrane interactions, revealing that membrane binding is regulated through phosphorylation of a conserved serine by its lipid recognition site.
format	article
author	Marc Lenoir Cansel Ustunel Sandya Rajesh Jaswant Kaur Dimitri Moreau Jean Gruenberg Michael Overduin
author_facet	Marc Lenoir Cansel Ustunel Sandya Rajesh Jaswant Kaur Dimitri Moreau Jean Gruenberg Michael Overduin
author_sort	Marc Lenoir
title	Phosphorylation of conserved phosphoinositide binding pocket regulates sorting nexin membrane targeting
title_short	Phosphorylation of conserved phosphoinositide binding pocket regulates sorting nexin membrane targeting
title_full	Phosphorylation of conserved phosphoinositide binding pocket regulates sorting nexin membrane targeting
title_fullStr	Phosphorylation of conserved phosphoinositide binding pocket regulates sorting nexin membrane targeting
title_full_unstemmed	Phosphorylation of conserved phosphoinositide binding pocket regulates sorting nexin membrane targeting
title_sort	phosphorylation of conserved phosphoinositide binding pocket regulates sorting nexin membrane targeting
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/86b2c9b181b3493589dd4feb5d76f8d4
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Phosphorylation of conserved phosphoinositide binding pocket regulates sorting nexin membrane targeting

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