Effects of cigarette smoke on Haemophilus influenzae-induced otitis media in a rat model

Abstract Exposure to cigarette smoke (CS) is a factor that could delay or worsen the recovery of otitis media (OM) by causing inflammatory swelling of the Eustachian tube (ET). However, despite the suggested relationship, little is known about the association between OM and CS. Therefore, we aimed t...

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Autores principales:	Sung-Won Choi, Sunmi Choi, Eun-Jin Kang, Hyun Min Lee, Se-Joon Oh, Il-Woo Lee, Hwan Ho Lee, Soo-Keun Kong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/86b6ee6634224bc9bd01fbe93e81101f
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spelling	oai:doaj.org-article:86b6ee6634224bc9bd01fbe93e81101f2021-12-02T18:37:08ZEffects of cigarette smoke on Haemophilus influenzae-induced otitis media in a rat model10.1038/s41598-021-99367-w2045-2322https://doaj.org/article/86b6ee6634224bc9bd01fbe93e81101f2021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99367-whttps://doaj.org/toc/2045-2322Abstract Exposure to cigarette smoke (CS) is a factor that could delay or worsen the recovery of otitis media (OM) by causing inflammatory swelling of the Eustachian tube (ET). However, despite the suggested relationship, little is known about the association between OM and CS. Therefore, we aimed to evaluate the effects of CS on the development, progression, and recovery of OM, as well as the histological and molecular changes caused by CS exposure, by using a rat model of OM infected with non-typeable Haemophilus influenzae (NTHi). Eighty Sprague–Dawley rats with normal middle ears (MEs) were divided into four groups (n = 20 rats/group): control, CS, OM, and CS + OM. The CS and CS + OM groups were exposed to CS for 2 weeks. The inflammatory reaction to NTHi was more intense and lasted longer in the CS + OM group than in the other groups. Goblet cell proliferation and mucus secretion in the ET were more significant in the CS and CS + OM groups than in the other groups. These findings suggested that because CS directly affects the ET and ME mucosa, bacterial OM can become more severe and may resolve more slowly in the presence of CS exposure rather than in its absence.Sung-Won ChoiSunmi ChoiEun-Jin KangHyun Min LeeSe-Joon OhIl-Woo LeeHwan Ho LeeSoo-Keun KongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sung-Won Choi Sunmi Choi Eun-Jin Kang Hyun Min Lee Se-Joon Oh Il-Woo Lee Hwan Ho Lee Soo-Keun Kong Effects of cigarette smoke on Haemophilus influenzae-induced otitis media in a rat model
description	Abstract Exposure to cigarette smoke (CS) is a factor that could delay or worsen the recovery of otitis media (OM) by causing inflammatory swelling of the Eustachian tube (ET). However, despite the suggested relationship, little is known about the association between OM and CS. Therefore, we aimed to evaluate the effects of CS on the development, progression, and recovery of OM, as well as the histological and molecular changes caused by CS exposure, by using a rat model of OM infected with non-typeable Haemophilus influenzae (NTHi). Eighty Sprague–Dawley rats with normal middle ears (MEs) were divided into four groups (n = 20 rats/group): control, CS, OM, and CS + OM. The CS and CS + OM groups were exposed to CS for 2 weeks. The inflammatory reaction to NTHi was more intense and lasted longer in the CS + OM group than in the other groups. Goblet cell proliferation and mucus secretion in the ET were more significant in the CS and CS + OM groups than in the other groups. These findings suggested that because CS directly affects the ET and ME mucosa, bacterial OM can become more severe and may resolve more slowly in the presence of CS exposure rather than in its absence.
format	article
author	Sung-Won Choi Sunmi Choi Eun-Jin Kang Hyun Min Lee Se-Joon Oh Il-Woo Lee Hwan Ho Lee Soo-Keun Kong
author_facet	Sung-Won Choi Sunmi Choi Eun-Jin Kang Hyun Min Lee Se-Joon Oh Il-Woo Lee Hwan Ho Lee Soo-Keun Kong
author_sort	Sung-Won Choi
title	Effects of cigarette smoke on Haemophilus influenzae-induced otitis media in a rat model
title_short	Effects of cigarette smoke on Haemophilus influenzae-induced otitis media in a rat model
title_full	Effects of cigarette smoke on Haemophilus influenzae-induced otitis media in a rat model
title_fullStr	Effects of cigarette smoke on Haemophilus influenzae-induced otitis media in a rat model
title_full_unstemmed	Effects of cigarette smoke on Haemophilus influenzae-induced otitis media in a rat model
title_sort	effects of cigarette smoke on haemophilus influenzae-induced otitis media in a rat model
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/86b6ee6634224bc9bd01fbe93e81101f
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Effects of cigarette smoke on Haemophilus influenzae-induced otitis media in a rat model

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