Activation and Identification of a Griseusin Cluster in <i>Streptomyces</i> sp. CA-256286 by Employing Transcriptional Regulators and Multi-Omics Methods

<i>Streptomyces</i> are well-known producers of a range of different secondary metabolites, including antibiotics and other bioactive compounds. Recently, it has been demonstrated that “silent” biosynthetic gene clusters (BGCs) can be activated by heterologously expressing transcriptiona...

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Autores principales:	Charlotte Beck, Tetiana Gren, Francisco Javier Ortiz-López, Tue Sparholt Jørgensen, Daniel Carretero-Molina, Jesús Martín Serrano, José R. Tormo, Daniel Oves-Costales, Eftychia E. Kontou, Omkar S. Mohite, Erik Mingyar, Evi Stegmann, Olga Genilloud, Tilmann Weber
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	transcriptional regulators biosynthetic gene cluster genome mining heterologous expression griseusin pyranonaphtoquinone Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/86badcd3f9eb4ba6bb5883784ca814da
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Activation and Identification of a Griseusin Cluster in <i>Streptomyces</i> sp. CA-256286 by Employing Transcriptional Regulators and Multi-Omics Methods

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