Co-stimulation with opposing macrophage polarization cues leads to orthogonal secretion programs in individual cells

Macrophages can be polarized by in vitro culture stimuli into M1 or M2 cells, but microenvironments in vivo are more complex. Here the authors analyze cultured macrophages stimulated with a combination of M1 and M2 stimuli by single-cell RNA sequencing, machine learning, and single-cell secretion pr...

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Bibliographic Details
Main Authors: Andrés R. Muñoz-Rojas, Ilana Kelsey, Jenna L. Pappalardo, Meibin Chen, Kathryn Miller-Jensen
Format: article
Language:EN
Published: Nature Portfolio 2021
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Online Access:https://doaj.org/article/86bb0282c387410a83e2eea9693c147b
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