Glutathione System in Sleep Disorders (Literature Review)

This review examines the variability of the glutathione system in sleep pathologies. Modern sleep theory assumes a restorative sleep function, including active utilization of oxidants and protection from excessive oxidation. In this review article, we conducted an analysis of domestic and foreign li...

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Autores principales:	A. S. Brichagina, N. V. Semenova, I. M. Madaeva
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2021
Materias:	glutathione system oxidative stress insomnia obstructive sleep apnea syndrome (osas) Science Q
Acceso en línea:	https://doaj.org/article/86bc0a4175b14326ad744b82d96cd923
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spelling	oai:doaj.org-article:86bc0a4175b14326ad744b82d96cd9232021-11-23T06:14:45ZGlutathione System in Sleep Disorders (Literature Review)2541-94202587-959610.29413/ABS.2020-5.6.15https://doaj.org/article/86bc0a4175b14326ad744b82d96cd9232021-01-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/2505https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596This review examines the variability of the glutathione system in sleep pathologies. Modern sleep theory assumes a restorative sleep function, including active utilization of oxidants and protection from excessive oxidation. In this review article, we conducted an analysis of domestic and foreign literature and summarized data relating aspects of the functioning of the glutathione system in somnological disorders. Various authors have established systemic oxidative stress in insomnia due to reduced activity of glutathione peroxidase. Also, oxidative stress in insomnia is observed in certain areas of the brain due to a decrease in glutathione levels in them. Studies of the functioning of the glutathione system genes in insomnia, whose polymorphisms may include alleles that inhibit oxidation, are arousing interest. An alternative pattern of changes is observed in obstructive sleep apnea syndrome. The apnea stage affects the indicators of the glutathione system. The values of the glutathione system indicators increase with mild to moderate apnea. This is an adaptive response mechanism. Also, the development of oxidative stress in apnea, which leads to disorders in the glutathione system, is cyclical. As a result, people with apnea do not have sufficient replenishment of the components of the glutathione system during sleep. The existing modification does not allow to fully respond to the intensification of peroxide processes and to restrain the activation of excessive oxidation.A. S. BrichaginaN. V. SemenovaI. M. MadaevaScientific Сentre for Family Health and Human Reproduction Problemsarticleglutathione systemoxidative stressinsomniaobstructive sleep apnea syndrome (osas)ScienceQRUActa Biomedica Scientifica, Vol 5, Iss 6, Pp 133-143 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	glutathione system oxidative stress insomnia obstructive sleep apnea syndrome (osas) Science Q
spellingShingle	glutathione system oxidative stress insomnia obstructive sleep apnea syndrome (osas) Science Q A. S. Brichagina N. V. Semenova I. M. Madaeva Glutathione System in Sleep Disorders (Literature Review)
description	This review examines the variability of the glutathione system in sleep pathologies. Modern sleep theory assumes a restorative sleep function, including active utilization of oxidants and protection from excessive oxidation. In this review article, we conducted an analysis of domestic and foreign literature and summarized data relating aspects of the functioning of the glutathione system in somnological disorders. Various authors have established systemic oxidative stress in insomnia due to reduced activity of glutathione peroxidase. Also, oxidative stress in insomnia is observed in certain areas of the brain due to a decrease in glutathione levels in them. Studies of the functioning of the glutathione system genes in insomnia, whose polymorphisms may include alleles that inhibit oxidation, are arousing interest. An alternative pattern of changes is observed in obstructive sleep apnea syndrome. The apnea stage affects the indicators of the glutathione system. The values of the glutathione system indicators increase with mild to moderate apnea. This is an adaptive response mechanism. Also, the development of oxidative stress in apnea, which leads to disorders in the glutathione system, is cyclical. As a result, people with apnea do not have sufficient replenishment of the components of the glutathione system during sleep. The existing modification does not allow to fully respond to the intensification of peroxide processes and to restrain the activation of excessive oxidation.
format	article
author	A. S. Brichagina N. V. Semenova I. M. Madaeva
author_facet	A. S. Brichagina N. V. Semenova I. M. Madaeva
author_sort	A. S. Brichagina
title	Glutathione System in Sleep Disorders (Literature Review)
title_short	Glutathione System in Sleep Disorders (Literature Review)
title_full	Glutathione System in Sleep Disorders (Literature Review)
title_fullStr	Glutathione System in Sleep Disorders (Literature Review)
title_full_unstemmed	Glutathione System in Sleep Disorders (Literature Review)
title_sort	glutathione system in sleep disorders (literature review)
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2021
url	https://doaj.org/article/86bc0a4175b14326ad744b82d96cd923
work_keys_str_mv	AT asbrichagina glutathionesysteminsleepdisordersliteraturereview AT nvsemenova glutathionesysteminsleepdisordersliteraturereview AT immadaeva glutathionesysteminsleepdisordersliteraturereview
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Glutathione System in Sleep Disorders (Literature Review)

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