Rieske iron-sulfur protein induces FKBP12.6/RyR2 complex remodeling and subsequent pulmonary hypertension through NF-κB/cyclin D1 pathway

Pulmonary hypertension is a devastating disease with elevation of pulmonary artery pressure and related to abnormal calcium signalling. Here, the authors show that suppression or stabilization of the calcium channel ryanodine receptor 2 may be a potential treatment approach for this disease.

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Auteurs principaux:	Lin Mei, Yun-Min Zheng, Tengyao Song, Vishal R. Yadav, Leroy C. Joseph, Lillian Truong, Sharath Kandhi, Margarida M. Barroso, Hiroshi Takeshima, Marc A. Judson, Yong-Xiao Wang
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2020
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/86bc37c2da5f4bbeb2cafd6fa120c8d0
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spelling	oai:doaj.org-article:86bc37c2da5f4bbeb2cafd6fa120c8d02021-12-02T17:01:22ZRieske iron-sulfur protein induces FKBP12.6/RyR2 complex remodeling and subsequent pulmonary hypertension through NF-κB/cyclin D1 pathway10.1038/s41467-020-17314-12041-1723https://doaj.org/article/86bc37c2da5f4bbeb2cafd6fa120c8d02020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17314-1https://doaj.org/toc/2041-1723Pulmonary hypertension is a devastating disease with elevation of pulmonary artery pressure and related to abnormal calcium signalling. Here, the authors show that suppression or stabilization of the calcium channel ryanodine receptor 2 may be a potential treatment approach for this disease.Lin MeiYun-Min ZhengTengyao SongVishal R. YadavLeroy C. JosephLillian TruongSharath KandhiMargarida M. BarrosoHiroshi TakeshimaMarc A. JudsonYong-Xiao WangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lin Mei Yun-Min Zheng Tengyao Song Vishal R. Yadav Leroy C. Joseph Lillian Truong Sharath Kandhi Margarida M. Barroso Hiroshi Takeshima Marc A. Judson Yong-Xiao Wang Rieske iron-sulfur protein induces FKBP12.6/RyR2 complex remodeling and subsequent pulmonary hypertension through NF-κB/cyclin D1 pathway
description	Pulmonary hypertension is a devastating disease with elevation of pulmonary artery pressure and related to abnormal calcium signalling. Here, the authors show that suppression or stabilization of the calcium channel ryanodine receptor 2 may be a potential treatment approach for this disease.
format	article
author	Lin Mei Yun-Min Zheng Tengyao Song Vishal R. Yadav Leroy C. Joseph Lillian Truong Sharath Kandhi Margarida M. Barroso Hiroshi Takeshima Marc A. Judson Yong-Xiao Wang
author_facet	Lin Mei Yun-Min Zheng Tengyao Song Vishal R. Yadav Leroy C. Joseph Lillian Truong Sharath Kandhi Margarida M. Barroso Hiroshi Takeshima Marc A. Judson Yong-Xiao Wang
author_sort	Lin Mei
title	Rieske iron-sulfur protein induces FKBP12.6/RyR2 complex remodeling and subsequent pulmonary hypertension through NF-κB/cyclin D1 pathway
title_short	Rieske iron-sulfur protein induces FKBP12.6/RyR2 complex remodeling and subsequent pulmonary hypertension through NF-κB/cyclin D1 pathway
title_full	Rieske iron-sulfur protein induces FKBP12.6/RyR2 complex remodeling and subsequent pulmonary hypertension through NF-κB/cyclin D1 pathway
title_fullStr	Rieske iron-sulfur protein induces FKBP12.6/RyR2 complex remodeling and subsequent pulmonary hypertension through NF-κB/cyclin D1 pathway
title_full_unstemmed	Rieske iron-sulfur protein induces FKBP12.6/RyR2 complex remodeling and subsequent pulmonary hypertension through NF-κB/cyclin D1 pathway
title_sort	rieske iron-sulfur protein induces fkbp12.6/ryr2 complex remodeling and subsequent pulmonary hypertension through nf-κb/cyclin d1 pathway
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/86bc37c2da5f4bbeb2cafd6fa120c8d0
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Rieske iron-sulfur protein induces FKBP12.6/RyR2 complex remodeling and subsequent pulmonary hypertension through NF-κB/cyclin D1 pathway

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