Rieske iron-sulfur protein induces FKBP12.6/RyR2 complex remodeling and subsequent pulmonary hypertension through NF-κB/cyclin D1 pathway
Pulmonary hypertension is a devastating disease with elevation of pulmonary artery pressure and related to abnormal calcium signalling. Here, the authors show that suppression or stabilization of the calcium channel ryanodine receptor 2 may be a potential treatment approach for this disease.
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Nature Portfolio
2020
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oai:doaj.org-article:86bc37c2da5f4bbeb2cafd6fa120c8d02021-12-02T17:01:22ZRieske iron-sulfur protein induces FKBP12.6/RyR2 complex remodeling and subsequent pulmonary hypertension through NF-κB/cyclin D1 pathway10.1038/s41467-020-17314-12041-1723https://doaj.org/article/86bc37c2da5f4bbeb2cafd6fa120c8d02020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17314-1https://doaj.org/toc/2041-1723Pulmonary hypertension is a devastating disease with elevation of pulmonary artery pressure and related to abnormal calcium signalling. Here, the authors show that suppression or stabilization of the calcium channel ryanodine receptor 2 may be a potential treatment approach for this disease.Lin MeiYun-Min ZhengTengyao SongVishal R. YadavLeroy C. JosephLillian TruongSharath KandhiMargarida M. BarrosoHiroshi TakeshimaMarc A. JudsonYong-Xiao WangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020) |
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DOAJ |
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EN |
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Science Q |
spellingShingle |
Science Q Lin Mei Yun-Min Zheng Tengyao Song Vishal R. Yadav Leroy C. Joseph Lillian Truong Sharath Kandhi Margarida M. Barroso Hiroshi Takeshima Marc A. Judson Yong-Xiao Wang Rieske iron-sulfur protein induces FKBP12.6/RyR2 complex remodeling and subsequent pulmonary hypertension through NF-κB/cyclin D1 pathway |
description |
Pulmonary hypertension is a devastating disease with elevation of pulmonary artery pressure and related to abnormal calcium signalling. Here, the authors show that suppression or stabilization of the calcium channel ryanodine receptor 2 may be a potential treatment approach for this disease. |
format |
article |
author |
Lin Mei Yun-Min Zheng Tengyao Song Vishal R. Yadav Leroy C. Joseph Lillian Truong Sharath Kandhi Margarida M. Barroso Hiroshi Takeshima Marc A. Judson Yong-Xiao Wang |
author_facet |
Lin Mei Yun-Min Zheng Tengyao Song Vishal R. Yadav Leroy C. Joseph Lillian Truong Sharath Kandhi Margarida M. Barroso Hiroshi Takeshima Marc A. Judson Yong-Xiao Wang |
author_sort |
Lin Mei |
title |
Rieske iron-sulfur protein induces FKBP12.6/RyR2 complex remodeling and subsequent pulmonary hypertension through NF-κB/cyclin D1 pathway |
title_short |
Rieske iron-sulfur protein induces FKBP12.6/RyR2 complex remodeling and subsequent pulmonary hypertension through NF-κB/cyclin D1 pathway |
title_full |
Rieske iron-sulfur protein induces FKBP12.6/RyR2 complex remodeling and subsequent pulmonary hypertension through NF-κB/cyclin D1 pathway |
title_fullStr |
Rieske iron-sulfur protein induces FKBP12.6/RyR2 complex remodeling and subsequent pulmonary hypertension through NF-κB/cyclin D1 pathway |
title_full_unstemmed |
Rieske iron-sulfur protein induces FKBP12.6/RyR2 complex remodeling and subsequent pulmonary hypertension through NF-κB/cyclin D1 pathway |
title_sort |
rieske iron-sulfur protein induces fkbp12.6/ryr2 complex remodeling and subsequent pulmonary hypertension through nf-κb/cyclin d1 pathway |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/86bc37c2da5f4bbeb2cafd6fa120c8d0 |
work_keys_str_mv |
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