Investigation of the impact of SARS-CoV infection on the immunologic status and lung function after 15 years

Abstract Background We investigate the long-term effects of SARS-CoV on patients’ lung and immune systems 15 years post-infection. SARS-CoV-2 pandemic is ongoing however, another genetically related beta-coronavirus SARS-CoV caused an epidemic in 2003–2004. Methods We enrolled 58 healthcare workers...

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Autores principales:	Jia Li, Yali Zheng, Lili Zhao, Zhihong Yue, Feng Pan, Yuehong Chen, Bing Yu, Yanwen Chen, Guangyu Zhao, Yusen Zhou, Zhancheng Gao
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Severe acute respiratory syndrome (SARS) SARS-CoV specific IgG antibody Regulatory T cell HRCT Pulmonary function test Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/86bd2d9134dd412d893f64775c689ad2
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spelling	oai:doaj.org-article:86bd2d9134dd412d893f64775c689ad22021-11-28T12:41:40ZInvestigation of the impact of SARS-CoV infection on the immunologic status and lung function after 15 years10.1186/s12879-021-06881-31471-2334https://doaj.org/article/86bd2d9134dd412d893f64775c689ad22021-11-01T00:00:00Zhttps://doi.org/10.1186/s12879-021-06881-3https://doaj.org/toc/1471-2334Abstract Background We investigate the long-term effects of SARS-CoV on patients’ lung and immune systems 15 years post-infection. SARS-CoV-2 pandemic is ongoing however, another genetically related beta-coronavirus SARS-CoV caused an epidemic in 2003–2004. Methods We enrolled 58 healthcare workers from Peking University People’s Hospital who were infected with SARS-CoV in 2003. We evaluated lung damage by mMRC score, pulmonary function tests, and chest CT. Immune function was assessed by their serum levels of globin, complete components, and peripheral T cell subsets. ELISA was used to detect SARS-CoV-specific IgG antibodies in sera. Results After 15 years of disease onset, 19 (36.5%), 8 (34.6%), and 19 (36.5%) subjects had impaired DL (CO), RV, and FEF25–75, respectively. 17 (30.4%) subjects had an mMRC score ≥ 2. Fourteen (25.5%) cases had residual CT abnormalities. T regulatory cells were a bit higher in the SARS survivors. IgG antibodies against SARS S-RBD protein and N protein were detected in 11 (18.97%) and 12 (20.69%) subjects, respectively. Subgroup analysis revealed that small airway dysfunction and CT abnormalities were more common in the severe group than in the non-severe group (57.1% vs 22.6%, 54.5% vs 6.1%, respectively, p < 0.05). Conclusions SARS-CoV could cause permanent damage to the lung, which requires early pulmonary rehabilitation. The long-lived immune memory response against coronavirus requires further studies to assess the potential benefit. Trial registration ClinicalTrials.gov, NCT03443102. Registered prospectively on 25 January 2018Jia LiYali ZhengLili ZhaoZhihong YueFeng PanYuehong ChenBing YuYanwen ChenGuangyu ZhaoYusen ZhouZhancheng GaoBMCarticleSevere acute respiratory syndrome (SARS)SARS-CoV specific IgG antibodyRegulatory T cellHRCTPulmonary function testInfectious and parasitic diseasesRC109-216ENBMC Infectious Diseases, Vol 21, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Severe acute respiratory syndrome (SARS) SARS-CoV specific IgG antibody Regulatory T cell HRCT Pulmonary function test Infectious and parasitic diseases RC109-216
spellingShingle	Severe acute respiratory syndrome (SARS) SARS-CoV specific IgG antibody Regulatory T cell HRCT Pulmonary function test Infectious and parasitic diseases RC109-216 Jia Li Yali Zheng Lili Zhao Zhihong Yue Feng Pan Yuehong Chen Bing Yu Yanwen Chen Guangyu Zhao Yusen Zhou Zhancheng Gao Investigation of the impact of SARS-CoV infection on the immunologic status and lung function after 15 years
description	Abstract Background We investigate the long-term effects of SARS-CoV on patients’ lung and immune systems 15 years post-infection. SARS-CoV-2 pandemic is ongoing however, another genetically related beta-coronavirus SARS-CoV caused an epidemic in 2003–2004. Methods We enrolled 58 healthcare workers from Peking University People’s Hospital who were infected with SARS-CoV in 2003. We evaluated lung damage by mMRC score, pulmonary function tests, and chest CT. Immune function was assessed by their serum levels of globin, complete components, and peripheral T cell subsets. ELISA was used to detect SARS-CoV-specific IgG antibodies in sera. Results After 15 years of disease onset, 19 (36.5%), 8 (34.6%), and 19 (36.5%) subjects had impaired DL (CO), RV, and FEF25–75, respectively. 17 (30.4%) subjects had an mMRC score ≥ 2. Fourteen (25.5%) cases had residual CT abnormalities. T regulatory cells were a bit higher in the SARS survivors. IgG antibodies against SARS S-RBD protein and N protein were detected in 11 (18.97%) and 12 (20.69%) subjects, respectively. Subgroup analysis revealed that small airway dysfunction and CT abnormalities were more common in the severe group than in the non-severe group (57.1% vs 22.6%, 54.5% vs 6.1%, respectively, p < 0.05). Conclusions SARS-CoV could cause permanent damage to the lung, which requires early pulmonary rehabilitation. The long-lived immune memory response against coronavirus requires further studies to assess the potential benefit. Trial registration ClinicalTrials.gov, NCT03443102. Registered prospectively on 25 January 2018
format	article
author	Jia Li Yali Zheng Lili Zhao Zhihong Yue Feng Pan Yuehong Chen Bing Yu Yanwen Chen Guangyu Zhao Yusen Zhou Zhancheng Gao
author_facet	Jia Li Yali Zheng Lili Zhao Zhihong Yue Feng Pan Yuehong Chen Bing Yu Yanwen Chen Guangyu Zhao Yusen Zhou Zhancheng Gao
author_sort	Jia Li
title	Investigation of the impact of SARS-CoV infection on the immunologic status and lung function after 15 years
title_short	Investigation of the impact of SARS-CoV infection on the immunologic status and lung function after 15 years
title_full	Investigation of the impact of SARS-CoV infection on the immunologic status and lung function after 15 years
title_fullStr	Investigation of the impact of SARS-CoV infection on the immunologic status and lung function after 15 years
title_full_unstemmed	Investigation of the impact of SARS-CoV infection on the immunologic status and lung function after 15 years
title_sort	investigation of the impact of sars-cov infection on the immunologic status and lung function after 15 years
publisher	BMC
publishDate	2021
url	https://doaj.org/article/86bd2d9134dd412d893f64775c689ad2
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Investigation of the impact of SARS-CoV infection on the immunologic status and lung function after 15 years

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