HOXA9 inhibits HIF-1α-mediated glycolysis through interacting with CRIP2 to repress cutaneous squamous cell carcinoma development

Hypoxia-inducible transcription factor HIF-1α promotes glycolysis allowing cell survival under stress. Here the authors show, using both cell lines and animal models, that in cutaneous squamous cell carcinoma HOXA9 acts as a tumor suppressor and inhibits glycolysis by associating with CRIP2 to repre...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Liang Zhou, Yinghui Wang, Meijuan Zhou, Ying Zhang, Pengfei Wang, Xiaoxing Li, Jing Yang, Hongmei Wang, Zhenhua Ding
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/86c0df53a8094fdcbfbfe9f6b984fb96
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:86c0df53a8094fdcbfbfe9f6b984fb96
record_format	dspace
spelling	oai:doaj.org-article:86c0df53a8094fdcbfbfe9f6b984fb962021-12-02T17:32:16ZHOXA9 inhibits HIF-1α-mediated glycolysis through interacting with CRIP2 to repress cutaneous squamous cell carcinoma development10.1038/s41467-018-03914-52041-1723https://doaj.org/article/86c0df53a8094fdcbfbfe9f6b984fb962018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03914-5https://doaj.org/toc/2041-1723Hypoxia-inducible transcription factor HIF-1α promotes glycolysis allowing cell survival under stress. Here the authors show, using both cell lines and animal models, that in cutaneous squamous cell carcinoma HOXA9 acts as a tumor suppressor and inhibits glycolysis by associating with CRIP2 to repress HIF-1α binding to target genes.Liang ZhouYinghui WangMeijuan ZhouYing ZhangPengfei WangXiaoxing LiJing YangHongmei WangZhenhua DingNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Liang Zhou Yinghui Wang Meijuan Zhou Ying Zhang Pengfei Wang Xiaoxing Li Jing Yang Hongmei Wang Zhenhua Ding HOXA9 inhibits HIF-1α-mediated glycolysis through interacting with CRIP2 to repress cutaneous squamous cell carcinoma development
description	Hypoxia-inducible transcription factor HIF-1α promotes glycolysis allowing cell survival under stress. Here the authors show, using both cell lines and animal models, that in cutaneous squamous cell carcinoma HOXA9 acts as a tumor suppressor and inhibits glycolysis by associating with CRIP2 to repress HIF-1α binding to target genes.
format	article
author	Liang Zhou Yinghui Wang Meijuan Zhou Ying Zhang Pengfei Wang Xiaoxing Li Jing Yang Hongmei Wang Zhenhua Ding
author_facet	Liang Zhou Yinghui Wang Meijuan Zhou Ying Zhang Pengfei Wang Xiaoxing Li Jing Yang Hongmei Wang Zhenhua Ding
author_sort	Liang Zhou
title	HOXA9 inhibits HIF-1α-mediated glycolysis through interacting with CRIP2 to repress cutaneous squamous cell carcinoma development
title_short	HOXA9 inhibits HIF-1α-mediated glycolysis through interacting with CRIP2 to repress cutaneous squamous cell carcinoma development
title_full	HOXA9 inhibits HIF-1α-mediated glycolysis through interacting with CRIP2 to repress cutaneous squamous cell carcinoma development
title_fullStr	HOXA9 inhibits HIF-1α-mediated glycolysis through interacting with CRIP2 to repress cutaneous squamous cell carcinoma development
title_full_unstemmed	HOXA9 inhibits HIF-1α-mediated glycolysis through interacting with CRIP2 to repress cutaneous squamous cell carcinoma development
title_sort	hoxa9 inhibits hif-1α-mediated glycolysis through interacting with crip2 to repress cutaneous squamous cell carcinoma development
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/86c0df53a8094fdcbfbfe9f6b984fb96
work_keys_str_mv	AT liangzhou hoxa9inhibitshif1amediatedglycolysisthroughinteractingwithcrip2torepresscutaneoussquamouscellcarcinomadevelopment AT yinghuiwang hoxa9inhibitshif1amediatedglycolysisthroughinteractingwithcrip2torepresscutaneoussquamouscellcarcinomadevelopment AT meijuanzhou hoxa9inhibitshif1amediatedglycolysisthroughinteractingwithcrip2torepresscutaneoussquamouscellcarcinomadevelopment AT yingzhang hoxa9inhibitshif1amediatedglycolysisthroughinteractingwithcrip2torepresscutaneoussquamouscellcarcinomadevelopment AT pengfeiwang hoxa9inhibitshif1amediatedglycolysisthroughinteractingwithcrip2torepresscutaneoussquamouscellcarcinomadevelopment AT xiaoxingli hoxa9inhibitshif1amediatedglycolysisthroughinteractingwithcrip2torepresscutaneoussquamouscellcarcinomadevelopment AT jingyang hoxa9inhibitshif1amediatedglycolysisthroughinteractingwithcrip2torepresscutaneoussquamouscellcarcinomadevelopment AT hongmeiwang hoxa9inhibitshif1amediatedglycolysisthroughinteractingwithcrip2torepresscutaneoussquamouscellcarcinomadevelopment AT zhenhuading hoxa9inhibitshif1amediatedglycolysisthroughinteractingwithcrip2torepresscutaneoussquamouscellcarcinomadevelopment
_version_	1718380381048143872

HOXA9 inhibits HIF-1α-mediated glycolysis through interacting with CRIP2 to repress cutaneous squamous cell carcinoma development

Ejemplares similares