Correlation between parity and metabolic syndrome in Chinese women aged 40 years and older: the Reaction study

Abstract Aims The purpose of the present study was to investigate the correlation between the number of live-birth pregnancies and metabolic syndrome (MetS) in Chinese women according to menstruation history. Methods Registry data for all pregnancies in a cohort of 6157 Chinese women aged 40 years o...

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Autores principales:	Qian Xie, Haoran Xu, Qin Wan
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Live-birth pregnancies Metabolic syndrome Menopause Diabetes Hypertension Obesity Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/86c27a5c5be2484e9d0a9ff322556f90
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spelling	oai:doaj.org-article:86c27a5c5be2484e9d0a9ff322556f902021-11-28T12:03:13ZCorrelation between parity and metabolic syndrome in Chinese women aged 40 years and older: the Reaction study10.1186/s12902-021-00902-71472-6823https://doaj.org/article/86c27a5c5be2484e9d0a9ff322556f902021-11-01T00:00:00Zhttps://doi.org/10.1186/s12902-021-00902-7https://doaj.org/toc/1472-6823Abstract Aims The purpose of the present study was to investigate the correlation between the number of live-birth pregnancies and metabolic syndrome (MetS) in Chinese women according to menstruation history. Methods Registry data for all pregnancies in a cohort of 6157 Chinese women aged 40 years or older were obtained and the number of live-birth pregnancies were enumerated. We defined MetS using five criteria: impaired insulin metabolism and glucose tolerance, obesity in the abdominal area, dyslipidemia, and hypertension. Multivariate logistic regression analysis was conducted to assess potential risk factors for MetS. Postmenopausal women with three or more of live-birth pregnancies had the highest prevalence of MetS (P < 0.05). Results Among the 6157 females aged 40 years or older in Luzhou city, 2143 (34.8%) participants had incident MetS. The number of live-birth pregnancies was significantly correlated with age and fasting blood glucose (FBG) level (P < 0.05). The prevalence of MetS increased with the number of live-birth pregnancies (P < 0.01), and the frequency in postmenopausal women was significantly higher than that in premenopausal women (P < 0.001). In the binary logistic regression model, menopausal status [OR = 0.343 (0.153–0.769), P < 0.001] were significantly associated with an increased risk of MetS. Conclusions The number of live-birth pregnancies is correlated with an increased risk of MetS in Chinese women aged 40 years and over, especially in postmenopausal women. Greater attention should be paid to postmenopausal women who have had multiple live-birth pregnancies with a view to intervening early to prevent related diseases.Qian XieHaoran XuQin WanBMCarticleLive-birth pregnanciesMetabolic syndromeMenopauseDiabetesHypertensionObesityDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENBMC Endocrine Disorders, Vol 21, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Live-birth pregnancies Metabolic syndrome Menopause Diabetes Hypertension Obesity Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	Live-birth pregnancies Metabolic syndrome Menopause Diabetes Hypertension Obesity Diseases of the endocrine glands. Clinical endocrinology RC648-665 Qian Xie Haoran Xu Qin Wan Correlation between parity and metabolic syndrome in Chinese women aged 40 years and older: the Reaction study
description	Abstract Aims The purpose of the present study was to investigate the correlation between the number of live-birth pregnancies and metabolic syndrome (MetS) in Chinese women according to menstruation history. Methods Registry data for all pregnancies in a cohort of 6157 Chinese women aged 40 years or older were obtained and the number of live-birth pregnancies were enumerated. We defined MetS using five criteria: impaired insulin metabolism and glucose tolerance, obesity in the abdominal area, dyslipidemia, and hypertension. Multivariate logistic regression analysis was conducted to assess potential risk factors for MetS. Postmenopausal women with three or more of live-birth pregnancies had the highest prevalence of MetS (P < 0.05). Results Among the 6157 females aged 40 years or older in Luzhou city, 2143 (34.8%) participants had incident MetS. The number of live-birth pregnancies was significantly correlated with age and fasting blood glucose (FBG) level (P < 0.05). The prevalence of MetS increased with the number of live-birth pregnancies (P < 0.01), and the frequency in postmenopausal women was significantly higher than that in premenopausal women (P < 0.001). In the binary logistic regression model, menopausal status [OR = 0.343 (0.153–0.769), P < 0.001] were significantly associated with an increased risk of MetS. Conclusions The number of live-birth pregnancies is correlated with an increased risk of MetS in Chinese women aged 40 years and over, especially in postmenopausal women. Greater attention should be paid to postmenopausal women who have had multiple live-birth pregnancies with a view to intervening early to prevent related diseases.
format	article
author	Qian Xie Haoran Xu Qin Wan
author_facet	Qian Xie Haoran Xu Qin Wan
author_sort	Qian Xie
title	Correlation between parity and metabolic syndrome in Chinese women aged 40 years and older: the Reaction study
title_short	Correlation between parity and metabolic syndrome in Chinese women aged 40 years and older: the Reaction study
title_full	Correlation between parity and metabolic syndrome in Chinese women aged 40 years and older: the Reaction study
title_fullStr	Correlation between parity and metabolic syndrome in Chinese women aged 40 years and older: the Reaction study
title_full_unstemmed	Correlation between parity and metabolic syndrome in Chinese women aged 40 years and older: the Reaction study
title_sort	correlation between parity and metabolic syndrome in chinese women aged 40 years and older: the reaction study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/86c27a5c5be2484e9d0a9ff322556f90
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_version_	1718408271131312128

Correlation between parity and metabolic syndrome in Chinese women aged 40 years and older: the Reaction study

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