Association Between Platelet-to-Lymphocyte Ratio and Preterm Necrotizing Enterocolitis

Introduction: Necrotizing enterocolitis (NEC) is a fatal condition for very-low-birth-weight infants. Necrotizing enterocolitis is a multi-factor phenomenon that results in intestinal mucosal damage and leads to intestinal necrosis. However, sensitive laboratory indicators for NEC are lacking, makin...

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Autores principales:	Juan Zheng, Hua Wang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	NEC PLR association preterm neonates prediction generalized additive models Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/86c418dab4df49eda2e80a09b6789ab6
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spelling	oai:doaj.org-article:86c418dab4df49eda2e80a09b6789ab62021-11-05T16:46:06ZAssociation Between Platelet-to-Lymphocyte Ratio and Preterm Necrotizing Enterocolitis2296-236010.3389/fped.2021.686880https://doaj.org/article/86c418dab4df49eda2e80a09b6789ab62021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fped.2021.686880/fullhttps://doaj.org/toc/2296-2360Introduction: Necrotizing enterocolitis (NEC) is a fatal condition for very-low-birth-weight infants. Necrotizing enterocolitis is a multi-factor phenomenon that results in intestinal mucosal damage and leads to intestinal necrosis. However, sensitive laboratory indicators for NEC are lacking, making early diagnosis difficult. This study aimed to explore the relationship between the platelet-to-lymphocyte ratio (PLR) and NEC in preterm neonates to enable an earlier diagnosis of the condition.Methods: This was a retrospective case–control study of preterm neonates diagnosed with NEC between January 2018 and December 2019 in the West China Second University Hospital. Controls were selected from preterm neonatal intensive care unit (NICU) graduates, and they were matched for gestation and year of birth to the preterms diagnosed without NEC. In total, 93 and 107 infants were included in the NEC and control groups, respectively. Empowerstats analysis was used to identify the association between PLR and preterm NEC.Results: The NEC group had significantly higher PLR levels than the control group. PLR > 100 within 1 week before NEC diagnosis was a risk factor for NEC. There was a positive connection between PLR and preterm NEC. A PLR of >100 was determined as the optimal cutoff for predicting preterm NEC, with patients with PLR >100 having a higher risk of NEC [odds ratio (OR): 18.82 (95% confidence interval (CI): 2.93–120.98), p = 0.002].Conclusions: A PLR of >100 within 1 week after clinical abnormalities is associated with a high risk of NEC in preterm neonates.Juan ZhengJuan ZhengJuan ZhengHua WangHua WangFrontiers Media S.A.articleNECPLRassociationpreterm neonatespredictiongeneralized additive modelsPediatricsRJ1-570ENFrontiers in Pediatrics, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	NEC PLR association preterm neonates prediction generalized additive models Pediatrics RJ1-570
spellingShingle	NEC PLR association preterm neonates prediction generalized additive models Pediatrics RJ1-570 Juan Zheng Juan Zheng Juan Zheng Hua Wang Hua Wang Association Between Platelet-to-Lymphocyte Ratio and Preterm Necrotizing Enterocolitis
description	Introduction: Necrotizing enterocolitis (NEC) is a fatal condition for very-low-birth-weight infants. Necrotizing enterocolitis is a multi-factor phenomenon that results in intestinal mucosal damage and leads to intestinal necrosis. However, sensitive laboratory indicators for NEC are lacking, making early diagnosis difficult. This study aimed to explore the relationship between the platelet-to-lymphocyte ratio (PLR) and NEC in preterm neonates to enable an earlier diagnosis of the condition.Methods: This was a retrospective case–control study of preterm neonates diagnosed with NEC between January 2018 and December 2019 in the West China Second University Hospital. Controls were selected from preterm neonatal intensive care unit (NICU) graduates, and they were matched for gestation and year of birth to the preterms diagnosed without NEC. In total, 93 and 107 infants were included in the NEC and control groups, respectively. Empowerstats analysis was used to identify the association between PLR and preterm NEC.Results: The NEC group had significantly higher PLR levels than the control group. PLR > 100 within 1 week before NEC diagnosis was a risk factor for NEC. There was a positive connection between PLR and preterm NEC. A PLR of >100 was determined as the optimal cutoff for predicting preterm NEC, with patients with PLR >100 having a higher risk of NEC [odds ratio (OR): 18.82 (95% confidence interval (CI): 2.93–120.98), p = 0.002].Conclusions: A PLR of >100 within 1 week after clinical abnormalities is associated with a high risk of NEC in preterm neonates.
format	article
author	Juan Zheng Juan Zheng Juan Zheng Hua Wang Hua Wang
author_facet	Juan Zheng Juan Zheng Juan Zheng Hua Wang Hua Wang
author_sort	Juan Zheng
title	Association Between Platelet-to-Lymphocyte Ratio and Preterm Necrotizing Enterocolitis
title_short	Association Between Platelet-to-Lymphocyte Ratio and Preterm Necrotizing Enterocolitis
title_full	Association Between Platelet-to-Lymphocyte Ratio and Preterm Necrotizing Enterocolitis
title_fullStr	Association Between Platelet-to-Lymphocyte Ratio and Preterm Necrotizing Enterocolitis
title_full_unstemmed	Association Between Platelet-to-Lymphocyte Ratio and Preterm Necrotizing Enterocolitis
title_sort	association between platelet-to-lymphocyte ratio and preterm necrotizing enterocolitis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/86c418dab4df49eda2e80a09b6789ab6
work_keys_str_mv	AT juanzheng associationbetweenplatelettolymphocyteratioandpretermnecrotizingenterocolitis AT juanzheng associationbetweenplatelettolymphocyteratioandpretermnecrotizingenterocolitis AT juanzheng associationbetweenplatelettolymphocyteratioandpretermnecrotizingenterocolitis AT huawang associationbetweenplatelettolymphocyteratioandpretermnecrotizingenterocolitis AT huawang associationbetweenplatelettolymphocyteratioandpretermnecrotizingenterocolitis
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Association Between Platelet-to-Lymphocyte Ratio and Preterm Necrotizing Enterocolitis

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