Acute and subacute toxicity study of the methanolic extract of olea europea.L leaves in Wistar rat

Olea europea.L (olive tree) is a plant widely used in the world. Its leaves have an extensive use in traditional herbal medicine to prevent and/or treat several diseases especially in Mediterranean regions. Despite this, research into the study of its toxicity is very limited in the literature. For...

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Autores principales:	Hinad Ibrahim, S’hih Youssef, El Gui Radia, Elhessni Aboubaker, Mesfioui Abdelhalim, Ouahidi Moulay laarbi
Formato:	article
Lenguaje:	EN FR
Publicado:	EDP Sciences 2021
Materias:	olea europea. l acute toxicity subchronic toxicity wistar rat Environmental sciences GE1-350
Acceso en línea:	https://doaj.org/article/86c6ea6af6b4474aa91c3d116e1f73c3
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spelling	oai:doaj.org-article:86c6ea6af6b4474aa91c3d116e1f73c32021-11-12T11:44:08ZAcute and subacute toxicity study of the methanolic extract of olea europea.L leaves in Wistar rat2267-124210.1051/e3sconf/202131901094https://doaj.org/article/86c6ea6af6b4474aa91c3d116e1f73c32021-01-01T00:00:00Zhttps://www.e3s-conferences.org/articles/e3sconf/pdf/2021/95/e3sconf_vigisan_01094.pdfhttps://doaj.org/toc/2267-1242Olea europea.L (olive tree) is a plant widely used in the world. Its leaves have an extensive use in traditional herbal medicine to prevent and/or treat several diseases especially in Mediterranean regions. Despite this, research into the study of its toxicity is very limited in the literature. For this, this study aims to study the acute and subacute toxicity of methanolic extract olive leaves in Wistar rats. To study acute toxicity, four dose levels (50,300,2000 and 5000 mg/kg body weight) were tested by single oral administration to Wistar rats. The subacute toxicity for 28 days was conducted by daily oral administration of methanolic extract of olive leaves at doses 1000,2000 and 3000 mg/kg in rats Wistar. After fourteen days of the administration of escalating doses, no deaths were recorded in the animals and no clinically detectable signs were observed. The results of subacute toxicity showed that the body weight of rats was not significantly changed by administration of methanolic extract of olive leaves. Monitoring of the behavior of the rats during the study showed the appearance of some manifestations of tremor, agitation and diarrhea in rats treated with the dose of 3000mg/kg. Grosse examination of the kidneys and liver revealed no changes in those organs and histopathological examination showed congestion and inflammation of the fat in rats treated with the dose of 3000mg/kg. the hematological profile showed no significant changes of the measured hematological parameters. Olive leaves should be used with care and caution since its methanolic extract caused some signs of toxicity and may affect the liver at repeated dose. however, more studies are needed to verify and clarify the toxic aspect of olea europea.L leaves.Hinad IbrahimS’hih YoussefEl Gui RadiaElhessni AboubakerMesfioui AbdelhalimOuahidi Moulay laarbiEDP Sciencesarticleolea europea. lacute toxicitysubchronic toxicitywistar ratEnvironmental sciencesGE1-350ENFRE3S Web of Conferences, Vol 319, p 01094 (2021)
institution	DOAJ
collection	DOAJ
language	EN FR
topic	olea europea. l acute toxicity subchronic toxicity wistar rat Environmental sciences GE1-350
spellingShingle	olea europea. l acute toxicity subchronic toxicity wistar rat Environmental sciences GE1-350 Hinad Ibrahim S’hih Youssef El Gui Radia Elhessni Aboubaker Mesfioui Abdelhalim Ouahidi Moulay laarbi Acute and subacute toxicity study of the methanolic extract of olea europea.L leaves in Wistar rat
description	Olea europea.L (olive tree) is a plant widely used in the world. Its leaves have an extensive use in traditional herbal medicine to prevent and/or treat several diseases especially in Mediterranean regions. Despite this, research into the study of its toxicity is very limited in the literature. For this, this study aims to study the acute and subacute toxicity of methanolic extract olive leaves in Wistar rats. To study acute toxicity, four dose levels (50,300,2000 and 5000 mg/kg body weight) were tested by single oral administration to Wistar rats. The subacute toxicity for 28 days was conducted by daily oral administration of methanolic extract of olive leaves at doses 1000,2000 and 3000 mg/kg in rats Wistar. After fourteen days of the administration of escalating doses, no deaths were recorded in the animals and no clinically detectable signs were observed. The results of subacute toxicity showed that the body weight of rats was not significantly changed by administration of methanolic extract of olive leaves. Monitoring of the behavior of the rats during the study showed the appearance of some manifestations of tremor, agitation and diarrhea in rats treated with the dose of 3000mg/kg. Grosse examination of the kidneys and liver revealed no changes in those organs and histopathological examination showed congestion and inflammation of the fat in rats treated with the dose of 3000mg/kg. the hematological profile showed no significant changes of the measured hematological parameters. Olive leaves should be used with care and caution since its methanolic extract caused some signs of toxicity and may affect the liver at repeated dose. however, more studies are needed to verify and clarify the toxic aspect of olea europea.L leaves.
format	article
author	Hinad Ibrahim S’hih Youssef El Gui Radia Elhessni Aboubaker Mesfioui Abdelhalim Ouahidi Moulay laarbi
author_facet	Hinad Ibrahim S’hih Youssef El Gui Radia Elhessni Aboubaker Mesfioui Abdelhalim Ouahidi Moulay laarbi
author_sort	Hinad Ibrahim
title	Acute and subacute toxicity study of the methanolic extract of olea europea.L leaves in Wistar rat
title_short	Acute and subacute toxicity study of the methanolic extract of olea europea.L leaves in Wistar rat
title_full	Acute and subacute toxicity study of the methanolic extract of olea europea.L leaves in Wistar rat
title_fullStr	Acute and subacute toxicity study of the methanolic extract of olea europea.L leaves in Wistar rat
title_full_unstemmed	Acute and subacute toxicity study of the methanolic extract of olea europea.L leaves in Wistar rat
title_sort	acute and subacute toxicity study of the methanolic extract of olea europea.l leaves in wistar rat
publisher	EDP Sciences
publishDate	2021
url	https://doaj.org/article/86c6ea6af6b4474aa91c3d116e1f73c3
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Acute and subacute toxicity study of the methanolic extract of olea europea.L leaves in Wistar rat

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