PATTERN OF LOCAL IMMUNE ALTERATIONS IN THE PATIENTS WITH CHRONIC ADENOIDITIS, AND AN OPPORTUNITY OF THEIR CORRECTION WITH IMUNOFAN

Abstract. The issue of chronic adenoiditis, due to its medical and social significance, is in focus of attention for otolaryngologists, pediatricians, immunologists. According to various works, chronic adenoiditis in children comprise 20 to 56% of upper respiratory diseases. Chronic adenoiditis is c...

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Autores principales:	R. N. Kuznetsova, K. A. Syssoev, V. V. Lebedev, A. V. Tutelian, Areg A. Totolian
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	local immunity immunoglobulins chronic adenoiditis imunofan Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/86cb71607f1a42239aefda313f112660
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spelling	oai:doaj.org-article:86cb71607f1a42239aefda313f1126602021-11-18T08:03:39ZPATTERN OF LOCAL IMMUNE ALTERATIONS IN THE PATIENTS WITH CHRONIC ADENOIDITIS, AND AN OPPORTUNITY OF THEIR CORRECTION WITH IMUNOFAN1563-06252313-741X10.15789/1563-0625-2008-6-551-562https://doaj.org/article/86cb71607f1a42239aefda313f1126602014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/268https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. The issue of chronic adenoiditis, due to its medical and social significance, is in focus of attention for otolaryngologists, pediatricians, immunologists. According to various works, chronic adenoiditis in children comprise 20 to 56% of upper respiratory diseases. Chronic adenoiditis is characterized by relative resistance to conventional therapy, and, in pronounced cases, by low reversibility of pathological events. The studies performed have shown that the patients with chronic adenoiditis show some features of local and general immune deficiency that were exhibited as decreased serum IgA concentration and local sIgA secretion, as well as insufficient income of IgG from vascular system to the area of inflammation in patients with chronic adenoiditis. These local immune deficiencies were considered to be an indication for local immunotherapy. Dynamics of clinical symptoms and changes in immunoglobulin profile has shown that clinical efficiency of Imunofan therapy was dependent not solely on the initial clinical features of disease, but on the local immunity state. Analysis of initial immunoglobulin concentrations in nasopharyngeal lavage from the patients showing differential clinical response have demonstrated that therapeutic effect of Imunofan was most pronounced in the patients with initially moderate activity of inflammatory process, deficient IgG income from vascular system, decreased local IgA synthesis in the inflammatory foci. Certain clinical features of chronic adenoiditis, i.e., clinical course without hypertrophy of pharyngeal tonsils, local immune deficiency (decreased local IgA secretion and deficient IgG income from blood), with a background of moderate inflammatory events, may be used as a rationale for administration of local immunotherapy with Imunofan to these patients. (Med. Immunol., 2008, vol. 10, N 6, pp 551-562).R. N. KuznetsovaK. A. SyssoevV. V. LebedevA. V. TutelianAreg A. TotolianSPb RAACIarticlelocal immunityimmunoglobulinschronic adenoiditisimunofanImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 10, Iss 6, Pp 551-562 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	local immunity immunoglobulins chronic adenoiditis imunofan Immunologic diseases. Allergy RC581-607
spellingShingle	local immunity immunoglobulins chronic adenoiditis imunofan Immunologic diseases. Allergy RC581-607 R. N. Kuznetsova K. A. Syssoev V. V. Lebedev A. V. Tutelian Areg A. Totolian PATTERN OF LOCAL IMMUNE ALTERATIONS IN THE PATIENTS WITH CHRONIC ADENOIDITIS, AND AN OPPORTUNITY OF THEIR CORRECTION WITH IMUNOFAN
description	Abstract. The issue of chronic adenoiditis, due to its medical and social significance, is in focus of attention for otolaryngologists, pediatricians, immunologists. According to various works, chronic adenoiditis in children comprise 20 to 56% of upper respiratory diseases. Chronic adenoiditis is characterized by relative resistance to conventional therapy, and, in pronounced cases, by low reversibility of pathological events. The studies performed have shown that the patients with chronic adenoiditis show some features of local and general immune deficiency that were exhibited as decreased serum IgA concentration and local sIgA secretion, as well as insufficient income of IgG from vascular system to the area of inflammation in patients with chronic adenoiditis. These local immune deficiencies were considered to be an indication for local immunotherapy. Dynamics of clinical symptoms and changes in immunoglobulin profile has shown that clinical efficiency of Imunofan therapy was dependent not solely on the initial clinical features of disease, but on the local immunity state. Analysis of initial immunoglobulin concentrations in nasopharyngeal lavage from the patients showing differential clinical response have demonstrated that therapeutic effect of Imunofan was most pronounced in the patients with initially moderate activity of inflammatory process, deficient IgG income from vascular system, decreased local IgA synthesis in the inflammatory foci. Certain clinical features of chronic adenoiditis, i.e., clinical course without hypertrophy of pharyngeal tonsils, local immune deficiency (decreased local IgA secretion and deficient IgG income from blood), with a background of moderate inflammatory events, may be used as a rationale for administration of local immunotherapy with Imunofan to these patients. (Med. Immunol., 2008, vol. 10, N 6, pp 551-562).
format	article
author	R. N. Kuznetsova K. A. Syssoev V. V. Lebedev A. V. Tutelian Areg A. Totolian
author_facet	R. N. Kuznetsova K. A. Syssoev V. V. Lebedev A. V. Tutelian Areg A. Totolian
author_sort	R. N. Kuznetsova
title	PATTERN OF LOCAL IMMUNE ALTERATIONS IN THE PATIENTS WITH CHRONIC ADENOIDITIS, AND AN OPPORTUNITY OF THEIR CORRECTION WITH IMUNOFAN
title_short	PATTERN OF LOCAL IMMUNE ALTERATIONS IN THE PATIENTS WITH CHRONIC ADENOIDITIS, AND AN OPPORTUNITY OF THEIR CORRECTION WITH IMUNOFAN
title_full	PATTERN OF LOCAL IMMUNE ALTERATIONS IN THE PATIENTS WITH CHRONIC ADENOIDITIS, AND AN OPPORTUNITY OF THEIR CORRECTION WITH IMUNOFAN
title_fullStr	PATTERN OF LOCAL IMMUNE ALTERATIONS IN THE PATIENTS WITH CHRONIC ADENOIDITIS, AND AN OPPORTUNITY OF THEIR CORRECTION WITH IMUNOFAN
title_full_unstemmed	PATTERN OF LOCAL IMMUNE ALTERATIONS IN THE PATIENTS WITH CHRONIC ADENOIDITIS, AND AN OPPORTUNITY OF THEIR CORRECTION WITH IMUNOFAN
title_sort	pattern of local immune alterations in the patients with chronic adenoiditis, and an opportunity of their correction with imunofan
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/86cb71607f1a42239aefda313f112660
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PATTERN OF LOCAL IMMUNE ALTERATIONS IN THE PATIENTS WITH CHRONIC ADENOIDITIS, AND AN OPPORTUNITY OF THEIR CORRECTION WITH IMUNOFAN

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