Retracted: Utility of the combined use of 3 serologic markers in the diagnosis and monitoring of chronic enteropathies in dogs

Abstract Background Dogs with chronic enteropathies (CE) displayed elevated IgA seropositivity against specific markers that can be used to develop a novel test. Objective To assess a multivariate test to aid diagnosis of CE in dogs and to monitor treatment‐related responses. Animals One hundred fif...

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Autores principales:	Juan Estruch, Jacqueline Johnson, Sarah Ford, Sean Yoshimoto, Tracy Mills, Philip Bergman
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	calprotectin CE/IBD GI monitoring gliadins OmpC Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/86ccc436c8df4ca19c5ad1cc2bb5d837
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spelling	oai:doaj.org-article:86ccc436c8df4ca19c5ad1cc2bb5d8372021-11-30T17:01:03ZRetracted: Utility of the combined use of 3 serologic markers in the diagnosis and monitoring of chronic enteropathies in dogs1939-16760891-664010.1111/jvim.16132https://doaj.org/article/86ccc436c8df4ca19c5ad1cc2bb5d8372021-05-01T00:00:00Zhttps://doi.org/10.1111/jvim.16132https://doaj.org/toc/0891-6640https://doaj.org/toc/1939-1676Abstract Background Dogs with chronic enteropathies (CE) displayed elevated IgA seropositivity against specific markers that can be used to develop a novel test. Objective To assess a multivariate test to aid diagnosis of CE in dogs and to monitor treatment‐related responses. Animals One hundred fifty‐seven dogs with CE/inflammatory bowel disease (IBD), 24 dogs non‐IBD gastrointestinal disorders, and 33 normal dogs. Methods Prospective, multicenter, clinical study that enrolled dogs with gastrointestinal disorders. Serum sample collected at enrollment and up to 3 months follow‐up measuring OmpC (ACA), canine calprotectin (ACNA), and gliadin‐derived peptides (AGA) by ELISA. Results Seropositivity was higher in CE/IBD than normal dogs (66% vs 9% for ACA; 55% vs 15% for ACNA; and 75% vs 6% for AGA; P < .001). When comparing CE/IBD with non‐IBD disease, ACA and ACNA displayed discriminating properties (66%, 55% vs 12.5%, 29% respectively) while AGA separated CE from normal cohorts (54% vs 6%). A 3‐marker algorithm at cutoff of ACA > 15, ACNA > 6, AGA > 60 differentiates CE/IBD and normal dogs with 90% sensitivity and 96% specificity; and CE/IBD and non‐IBD dogs with 80% sensitivity and 86% specificity. Titers decreased after treatment (47%‐99% in ACA, 13%‐88% in ACNA, and 30%‐85% in AGA), changes that were concurrent with clinical improvements. Conclusion and Clinical Importance An assay based on combined measurements of ACA, ACNA, and AGA is useful as a noninvasive diagnostic test to distinguish dogs with CE/IBD. The test also has the potential to monitor response to treatment.Juan EstruchJacqueline JohnsonSarah FordSean YoshimotoTracy MillsPhilip BergmanWileyarticlecalprotectinCE/IBDGI monitoringgliadinsOmpCVeterinary medicineSF600-1100ENJournal of Veterinary Internal Medicine, Vol 35, Iss 3, Pp 1306-1315 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	calprotectin CE/IBD GI monitoring gliadins OmpC Veterinary medicine SF600-1100
spellingShingle	calprotectin CE/IBD GI monitoring gliadins OmpC Veterinary medicine SF600-1100 Juan Estruch Jacqueline Johnson Sarah Ford Sean Yoshimoto Tracy Mills Philip Bergman Retracted: Utility of the combined use of 3 serologic markers in the diagnosis and monitoring of chronic enteropathies in dogs
description	Abstract Background Dogs with chronic enteropathies (CE) displayed elevated IgA seropositivity against specific markers that can be used to develop a novel test. Objective To assess a multivariate test to aid diagnosis of CE in dogs and to monitor treatment‐related responses. Animals One hundred fifty‐seven dogs with CE/inflammatory bowel disease (IBD), 24 dogs non‐IBD gastrointestinal disorders, and 33 normal dogs. Methods Prospective, multicenter, clinical study that enrolled dogs with gastrointestinal disorders. Serum sample collected at enrollment and up to 3 months follow‐up measuring OmpC (ACA), canine calprotectin (ACNA), and gliadin‐derived peptides (AGA) by ELISA. Results Seropositivity was higher in CE/IBD than normal dogs (66% vs 9% for ACA; 55% vs 15% for ACNA; and 75% vs 6% for AGA; P < .001). When comparing CE/IBD with non‐IBD disease, ACA and ACNA displayed discriminating properties (66%, 55% vs 12.5%, 29% respectively) while AGA separated CE from normal cohorts (54% vs 6%). A 3‐marker algorithm at cutoff of ACA > 15, ACNA > 6, AGA > 60 differentiates CE/IBD and normal dogs with 90% sensitivity and 96% specificity; and CE/IBD and non‐IBD dogs with 80% sensitivity and 86% specificity. Titers decreased after treatment (47%‐99% in ACA, 13%‐88% in ACNA, and 30%‐85% in AGA), changes that were concurrent with clinical improvements. Conclusion and Clinical Importance An assay based on combined measurements of ACA, ACNA, and AGA is useful as a noninvasive diagnostic test to distinguish dogs with CE/IBD. The test also has the potential to monitor response to treatment.
format	article
author	Juan Estruch Jacqueline Johnson Sarah Ford Sean Yoshimoto Tracy Mills Philip Bergman
author_facet	Juan Estruch Jacqueline Johnson Sarah Ford Sean Yoshimoto Tracy Mills Philip Bergman
author_sort	Juan Estruch
title	Retracted: Utility of the combined use of 3 serologic markers in the diagnosis and monitoring of chronic enteropathies in dogs
title_short	Retracted: Utility of the combined use of 3 serologic markers in the diagnosis and monitoring of chronic enteropathies in dogs
title_full	Retracted: Utility of the combined use of 3 serologic markers in the diagnosis and monitoring of chronic enteropathies in dogs
title_fullStr	Retracted: Utility of the combined use of 3 serologic markers in the diagnosis and monitoring of chronic enteropathies in dogs
title_full_unstemmed	Retracted: Utility of the combined use of 3 serologic markers in the diagnosis and monitoring of chronic enteropathies in dogs
title_sort	retracted: utility of the combined use of 3 serologic markers in the diagnosis and monitoring of chronic enteropathies in dogs
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/86ccc436c8df4ca19c5ad1cc2bb5d837
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Retracted: Utility of the combined use of 3 serologic markers in the diagnosis and monitoring of chronic enteropathies in dogs

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