Cognitive Function in Adults with Beta-Thalassemia Major in Oman: A Pilot Study

Objectives: Neurocognitive dysfunction has been established in several studies in children with beta-thalassemia major (TM). However, despite its wide occurrence in populations across the Arabian Peninsula, scant attention has been paid to shedding light on neuropsychological functioning among adult...

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Autores principales:	Shahina Daar, Muna Al Saadoon, Yasser Wali, Rawan Al Mujaini, Sarah Al Rahbi, Moon Fai Chan, Alya Al-Siyabi, Niveen Alansary, Sangeetha Mahadevan, Samir Al-Adawi
Formato:	article
Lenguaje:	EN
Publicado:	Oman Medical Specialty Board 2021
Materias:	b-thalassemia memory short-term neuropsychological tests anxiety cognition executive function depression oman Medicine R
Acceso en línea:	https://doaj.org/article/86d128950341486cb0af2eea57eddeec
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spelling	oai:doaj.org-article:86d128950341486cb0af2eea57eddeec2021-11-30T05:38:35ZCognitive Function in Adults with Beta-Thalassemia Major in Oman: A Pilot Study10.5001/omj.2021.1011999-768X2070-5204https://doaj.org/article/86d128950341486cb0af2eea57eddeec2021-11-01T00:00:00Zhttps://omjournal.org/articleDetails.aspx?coType=1&aId=3028https://doaj.org/toc/1999-768Xhttps://doaj.org/toc/2070-5204Objectives: Neurocognitive dysfunction has been established in several studies in children with beta-thalassemia major (TM). However, despite its wide occurrence in populations across the Arabian Peninsula, scant attention has been paid to shedding light on neuropsychological functioning among adults with TM. This study aimed to examine the level of neuropsychological functioning among Omani adults with TM regularly followed-up at a tertiary care hospital in Oman. A related aim was to examine the factors associated with neuropsychological performance. Methods: Standard neuropsychological tests were used to measure attention and concentration, learning and remembering, verbal fluency, and executive functioning. Participants were also gauged on indices of intellectual ability and affective range. As normative data for neuropsychological functioning in Oman is scarce, healthy age- and sex-matched controls underwent the same testing procedure. The log-linear model was used to identify factors associated with TM patients on demographic and neuropsychological performance. Results: This study recruited 28 adult patients with TM (age 30.0±6.5) and 39 healthy controls (age 29.2±6.1). Findings suggested that having a diagnosis of TM was significantly associated with symptoms of depression (p < 0.001) and anxiety (p < 0.001), indices of executive functioning (verbal fluency) (p =0.003), working memory (digit span) (p < 0.001), and verbal and auditory attention scores (California Verbal Learning, p = 0.002). Conclusions: The data appears to suggest that short-term memory capacity, verbal fluency, and verbal and auditory attention may be impaired in TM compared to controls. Studies on a larger cohort are therefore warranted.Shahina DaarMuna Al SaadoonYasser WaliRawan Al MujainiSarah Al RahbiMoon Fai ChanAlya Al-SiyabiNiveen AlansarySangeetha MahadevanSamir Al-AdawiOman Medical Specialty Boardarticleb-thalassemiamemoryshort-termneuropsychological testsanxietycognitionexecutive functiondepressionomanMedicineRENOman Medical Journal, Vol 36, Iss 6, Pp e322-e322 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	b-thalassemia memory short-term neuropsychological tests anxiety cognition executive function depression oman Medicine R
spellingShingle	b-thalassemia memory short-term neuropsychological tests anxiety cognition executive function depression oman Medicine R Shahina Daar Muna Al Saadoon Yasser Wali Rawan Al Mujaini Sarah Al Rahbi Moon Fai Chan Alya Al-Siyabi Niveen Alansary Sangeetha Mahadevan Samir Al-Adawi Cognitive Function in Adults with Beta-Thalassemia Major in Oman: A Pilot Study
description	Objectives: Neurocognitive dysfunction has been established in several studies in children with beta-thalassemia major (TM). However, despite its wide occurrence in populations across the Arabian Peninsula, scant attention has been paid to shedding light on neuropsychological functioning among adults with TM. This study aimed to examine the level of neuropsychological functioning among Omani adults with TM regularly followed-up at a tertiary care hospital in Oman. A related aim was to examine the factors associated with neuropsychological performance. Methods: Standard neuropsychological tests were used to measure attention and concentration, learning and remembering, verbal fluency, and executive functioning. Participants were also gauged on indices of intellectual ability and affective range. As normative data for neuropsychological functioning in Oman is scarce, healthy age- and sex-matched controls underwent the same testing procedure. The log-linear model was used to identify factors associated with TM patients on demographic and neuropsychological performance. Results: This study recruited 28 adult patients with TM (age 30.0±6.5) and 39 healthy controls (age 29.2±6.1). Findings suggested that having a diagnosis of TM was significantly associated with symptoms of depression (p < 0.001) and anxiety (p < 0.001), indices of executive functioning (verbal fluency) (p =0.003), working memory (digit span) (p < 0.001), and verbal and auditory attention scores (California Verbal Learning, p = 0.002). Conclusions: The data appears to suggest that short-term memory capacity, verbal fluency, and verbal and auditory attention may be impaired in TM compared to controls. Studies on a larger cohort are therefore warranted.
format	article
author	Shahina Daar Muna Al Saadoon Yasser Wali Rawan Al Mujaini Sarah Al Rahbi Moon Fai Chan Alya Al-Siyabi Niveen Alansary Sangeetha Mahadevan Samir Al-Adawi
author_facet	Shahina Daar Muna Al Saadoon Yasser Wali Rawan Al Mujaini Sarah Al Rahbi Moon Fai Chan Alya Al-Siyabi Niveen Alansary Sangeetha Mahadevan Samir Al-Adawi
author_sort	Shahina Daar
title	Cognitive Function in Adults with Beta-Thalassemia Major in Oman: A Pilot Study
title_short	Cognitive Function in Adults with Beta-Thalassemia Major in Oman: A Pilot Study
title_full	Cognitive Function in Adults with Beta-Thalassemia Major in Oman: A Pilot Study
title_fullStr	Cognitive Function in Adults with Beta-Thalassemia Major in Oman: A Pilot Study
title_full_unstemmed	Cognitive Function in Adults with Beta-Thalassemia Major in Oman: A Pilot Study
title_sort	cognitive function in adults with beta-thalassemia major in oman: a pilot study
publisher	Oman Medical Specialty Board
publishDate	2021
url	https://doaj.org/article/86d128950341486cb0af2eea57eddeec
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Cognitive Function in Adults with Beta-Thalassemia Major in Oman: A Pilot Study

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