A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication
Here, using in vitro assays and structural analysis, the authors characterize the anti-SARS-CoV-2 properties of two small molcules, showing these to bind and target the virus main protease (Mpro), and to exhibit a synergistic antiviral effect when combined with remdesivir in vitro.
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Nature Portfolio
2021
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oai:doaj.org-article:86d3e81f7e794c15baedd9ad9a9684122021-12-02T13:57:44ZA small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication10.1038/s41467-021-20900-62041-1723https://doaj.org/article/86d3e81f7e794c15baedd9ad9a9684122021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-20900-6https://doaj.org/toc/2041-1723Here, using in vitro assays and structural analysis, the authors characterize the anti-SARS-CoV-2 properties of two small molcules, showing these to bind and target the virus main protease (Mpro), and to exhibit a synergistic antiviral effect when combined with remdesivir in vitro.Shin-ichiro HattoriNobuyo Higashi-KuwataHironori HayashiSrinivasa Rao AlluJakka RaghavaiahHaydar BulutDebananda DasBrandon J. AnsonEmma K. LendyYuki TakamatsuNobutoki TakamuneNaoki KishimotoKazutaka MurayamaKazuya HasegawaMi LiDavid A. DavisEiichi N. KodamaRobert YarchoanAlexander WlodawerShogo MisumiAndrew D. MesecarArun K. GhoshHiroaki MitsuyaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021) |
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Science Q |
| spellingShingle |
Science Q Shin-ichiro Hattori Nobuyo Higashi-Kuwata Hironori Hayashi Srinivasa Rao Allu Jakka Raghavaiah Haydar Bulut Debananda Das Brandon J. Anson Emma K. Lendy Yuki Takamatsu Nobutoki Takamune Naoki Kishimoto Kazutaka Murayama Kazuya Hasegawa Mi Li David A. Davis Eiichi N. Kodama Robert Yarchoan Alexander Wlodawer Shogo Misumi Andrew D. Mesecar Arun K. Ghosh Hiroaki Mitsuya A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication |
| description |
Here, using in vitro assays and structural analysis, the authors characterize the anti-SARS-CoV-2 properties of two small molcules, showing these to bind and target the virus main protease (Mpro), and to exhibit a synergistic antiviral effect when combined with remdesivir in vitro. |
| format |
article |
| author |
Shin-ichiro Hattori Nobuyo Higashi-Kuwata Hironori Hayashi Srinivasa Rao Allu Jakka Raghavaiah Haydar Bulut Debananda Das Brandon J. Anson Emma K. Lendy Yuki Takamatsu Nobutoki Takamune Naoki Kishimoto Kazutaka Murayama Kazuya Hasegawa Mi Li David A. Davis Eiichi N. Kodama Robert Yarchoan Alexander Wlodawer Shogo Misumi Andrew D. Mesecar Arun K. Ghosh Hiroaki Mitsuya |
| author_facet |
Shin-ichiro Hattori Nobuyo Higashi-Kuwata Hironori Hayashi Srinivasa Rao Allu Jakka Raghavaiah Haydar Bulut Debananda Das Brandon J. Anson Emma K. Lendy Yuki Takamatsu Nobutoki Takamune Naoki Kishimoto Kazutaka Murayama Kazuya Hasegawa Mi Li David A. Davis Eiichi N. Kodama Robert Yarchoan Alexander Wlodawer Shogo Misumi Andrew D. Mesecar Arun K. Ghosh Hiroaki Mitsuya |
| author_sort |
Shin-ichiro Hattori |
| title |
A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication |
| title_short |
A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication |
| title_full |
A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication |
| title_fullStr |
A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication |
| title_full_unstemmed |
A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication |
| title_sort |
small molecule compound with an indole moiety inhibits the main protease of sars-cov-2 and blocks virus replication |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/86d3e81f7e794c15baedd9ad9a968412 |
| work_keys_str_mv |
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