Molecular mechanisms of the influenza fusion peptide: insights from experimental and simulation studies

A key step in infections by enveloped viruses, such as influenza, is the fusion between the viral envelope and the host cell membrane, which allows the virus to insert its genetic material into the host cell and replicate. The influenza virus fusion process is promoted by hemagglutinin (HA), a glyco...

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Autores principales:	Diana Lousa, Cláudio M. Soares
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	biophysical assays hemagglutinin influenza membrane fusion molecular dynamics simulation virus Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/86d90d51223f4741b9b63db0e9235e79
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spelling	oai:doaj.org-article:86d90d51223f4741b9b63db0e9235e792021-12-01T13:36:12ZMolecular mechanisms of the influenza fusion peptide: insights from experimental and simulation studies2211-546310.1002/2211-5463.13323https://doaj.org/article/86d90d51223f4741b9b63db0e9235e792021-12-01T00:00:00Zhttps://doi.org/10.1002/2211-5463.13323https://doaj.org/toc/2211-5463A key step in infections by enveloped viruses, such as influenza, is the fusion between the viral envelope and the host cell membrane, which allows the virus to insert its genetic material into the host cell and replicate. The influenza virus fusion process is promoted by hemagglutinin (HA), a glycoprotein that contains three identical monomers composed of two polypeptide chains (HA1 and HA2). Early studies on this protein revealed that HA‐mediated fusion involves the insertion of the HA2 N‐terminal segment into the host membrane and that this segment, known as the fusion peptide, is a key player in the fusion process. This mini‐review highlights the main findings that have been obtained by experimental and computational studies on the HA fusion peptide, which give us a glimpse of its mode of action.Diana LousaCláudio M. SoaresWileyarticlebiophysical assayshemagglutinininfluenzamembrane fusionmolecular dynamics simulationvirusBiology (General)QH301-705.5ENFEBS Open Bio, Vol 11, Iss 12, Pp 3253-3261 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	biophysical assays hemagglutinin influenza membrane fusion molecular dynamics simulation virus Biology (General) QH301-705.5
spellingShingle	biophysical assays hemagglutinin influenza membrane fusion molecular dynamics simulation virus Biology (General) QH301-705.5 Diana Lousa Cláudio M. Soares Molecular mechanisms of the influenza fusion peptide: insights from experimental and simulation studies
description	A key step in infections by enveloped viruses, such as influenza, is the fusion between the viral envelope and the host cell membrane, which allows the virus to insert its genetic material into the host cell and replicate. The influenza virus fusion process is promoted by hemagglutinin (HA), a glycoprotein that contains three identical monomers composed of two polypeptide chains (HA1 and HA2). Early studies on this protein revealed that HA‐mediated fusion involves the insertion of the HA2 N‐terminal segment into the host membrane and that this segment, known as the fusion peptide, is a key player in the fusion process. This mini‐review highlights the main findings that have been obtained by experimental and computational studies on the HA fusion peptide, which give us a glimpse of its mode of action.
format	article
author	Diana Lousa Cláudio M. Soares
author_facet	Diana Lousa Cláudio M. Soares
author_sort	Diana Lousa
title	Molecular mechanisms of the influenza fusion peptide: insights from experimental and simulation studies
title_short	Molecular mechanisms of the influenza fusion peptide: insights from experimental and simulation studies
title_full	Molecular mechanisms of the influenza fusion peptide: insights from experimental and simulation studies
title_fullStr	Molecular mechanisms of the influenza fusion peptide: insights from experimental and simulation studies
title_full_unstemmed	Molecular mechanisms of the influenza fusion peptide: insights from experimental and simulation studies
title_sort	molecular mechanisms of the influenza fusion peptide: insights from experimental and simulation studies
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/86d90d51223f4741b9b63db0e9235e79
work_keys_str_mv	AT dianalousa molecularmechanismsoftheinfluenzafusionpeptideinsightsfromexperimentalandsimulationstudies AT claudiomsoares molecularmechanismsoftheinfluenzafusionpeptideinsightsfromexperimentalandsimulationstudies
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Molecular mechanisms of the influenza fusion peptide: insights from experimental and simulation studies

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