Efficacy of Perioperative Continuous Intravenous Lidocaine Infusion for 72 Hours on Postoperative Pain and Recovery in Patients Undergoing Hepatectomy: Study Protocol for a Prospective Randomized Controlled Trial

Yan Xu,1 Mao Ye,1 Ying Hong,1 Yi Kang,2 Yue Li,1 Xiao Xiao,1 Li Zhou,1 Chunling Jiang1 1Department of Anesthesiology, West China Hospital, Sichuan University & The Research Units of West China (2018RU012), Chinese Academy of Medical Sciences, Chengdu, 610041, People’s Republic of China; 2Departm...

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Autores principales:	Xu Y, Ye M, Hong Y, Kang Y, Li Y, Xiao X, Zhou L, Jiang C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	intravenous lidocaine hepatectomy postoperative pain recovery. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/86db1aa38c8a4ec3a920bd96cd10a248
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spelling	oai:doaj.org-article:86db1aa38c8a4ec3a920bd96cd10a2482021-11-30T18:50:37ZEfficacy of Perioperative Continuous Intravenous Lidocaine Infusion for 72 Hours on Postoperative Pain and Recovery in Patients Undergoing Hepatectomy: Study Protocol for a Prospective Randomized Controlled Trial1178-7090https://doaj.org/article/86db1aa38c8a4ec3a920bd96cd10a2482021-12-01T00:00:00Zhttps://www.dovepress.com/efficacy-of-perioperative-continuous-intravenous-lidocaine-infusion-fo-peer-reviewed-fulltext-article-JPRhttps://doaj.org/toc/1178-7090Yan Xu,1 Mao Ye,1 Ying Hong,1 Yi Kang,2 Yue Li,1 Xiao Xiao,1 Li Zhou,1 Chunling Jiang1 1Department of Anesthesiology, West China Hospital, Sichuan University & The Research Units of West China (2018RU012), Chinese Academy of Medical Sciences, Chengdu, 610041, People’s Republic of China; 2Department of Anesthesiology and Translational Neuroscience Center, Laboratory of Anesthesia and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, 610041, People’s Republic of ChinaCorrespondence: Chunling JiangDepartment of Anesthesiology, West China Hospital, Sichuan University & The Research Units of West China (2018RU012), Chinese Academy of Medical Sciences, Chengdu, 610041, People’s Republic of ChinaTel/Fax +86-28-8542-3593Email jiangchunling@scu.edu.cnPurpose: Many patients develop severe and persistent pain after hepatectomy delaying postoperative rehabilitation. Studies have suggested that intravenous lidocaine infusion relieved postoperative pain and improved overall postoperative outcomes. However, its efficacy on hepatectomy is still masked, due to the postoperative metabolic change of lidocaine by the liver. We hypothesized that intravenous lidocaine infusion in the perioperative period would lead to postoperative pain reduction and improve the overall patient experience.Study Design and Methods: In this prospective double-blind, randomized controlled design trial, 260 adults scheduled for hepatectomy will be allocated to the lidocaine and the placebo groups. The lidocaine group will be administered lidocaine intravenously during intraoperative period and 72 postoperative hours; the placebo group will be administered normal saline at the same volume, infusion rate, and timing. The primary outcome is the incidence of moderate-severe pain (numeric rating scale ≥ 4) during movement at 24 hours after surgery. The secondary outcomes include the incidence of moderate-severe pain at 24 hours after surgery at rest, the incidence of moderate-severe pain at 48 and 72 hours after surgery at rest and during movement, the cumulative morphine consumption at 24, 48 and 72 hours postoperatively, bowel function recovery, the incidence of postoperative nausea and vomiting, the incidence of postoperative pulmonary complications, the length of hospital stay, levels of inflammatory factors and patient satisfaction scores.Discussion: This is the first prospective trial to shed light on the efficacy of intraoperative period and 72 postoperative hours intravenous lidocaine on postoperative pain and recovery after hepatectomy. The findings will provide a new strategy of perioperative pain management for hepatectomy.Keywords: intravenous lidocaine, hepatectomy, postoperative pain, recoveryXu YYe MHong YKang YLi YXiao XZhou LJiang CDove Medical Pressarticleintravenous lidocainehepatectomypostoperative painrecovery.Medicine (General)R5-920ENJournal of Pain Research, Vol Volume 14, Pp 3665-3674 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	intravenous lidocaine hepatectomy postoperative pain recovery. Medicine (General) R5-920
spellingShingle	intravenous lidocaine hepatectomy postoperative pain recovery. Medicine (General) R5-920 Xu Y Ye M Hong Y Kang Y Li Y Xiao X Zhou L Jiang C Efficacy of Perioperative Continuous Intravenous Lidocaine Infusion for 72 Hours on Postoperative Pain and Recovery in Patients Undergoing Hepatectomy: Study Protocol for a Prospective Randomized Controlled Trial
description	Yan Xu,1 Mao Ye,1 Ying Hong,1 Yi Kang,2 Yue Li,1 Xiao Xiao,1 Li Zhou,1 Chunling Jiang1 1Department of Anesthesiology, West China Hospital, Sichuan University & The Research Units of West China (2018RU012), Chinese Academy of Medical Sciences, Chengdu, 610041, People’s Republic of China; 2Department of Anesthesiology and Translational Neuroscience Center, Laboratory of Anesthesia and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, 610041, People’s Republic of ChinaCorrespondence: Chunling JiangDepartment of Anesthesiology, West China Hospital, Sichuan University & The Research Units of West China (2018RU012), Chinese Academy of Medical Sciences, Chengdu, 610041, People’s Republic of ChinaTel/Fax +86-28-8542-3593Email jiangchunling@scu.edu.cnPurpose: Many patients develop severe and persistent pain after hepatectomy delaying postoperative rehabilitation. Studies have suggested that intravenous lidocaine infusion relieved postoperative pain and improved overall postoperative outcomes. However, its efficacy on hepatectomy is still masked, due to the postoperative metabolic change of lidocaine by the liver. We hypothesized that intravenous lidocaine infusion in the perioperative period would lead to postoperative pain reduction and improve the overall patient experience.Study Design and Methods: In this prospective double-blind, randomized controlled design trial, 260 adults scheduled for hepatectomy will be allocated to the lidocaine and the placebo groups. The lidocaine group will be administered lidocaine intravenously during intraoperative period and 72 postoperative hours; the placebo group will be administered normal saline at the same volume, infusion rate, and timing. The primary outcome is the incidence of moderate-severe pain (numeric rating scale ≥ 4) during movement at 24 hours after surgery. The secondary outcomes include the incidence of moderate-severe pain at 24 hours after surgery at rest, the incidence of moderate-severe pain at 48 and 72 hours after surgery at rest and during movement, the cumulative morphine consumption at 24, 48 and 72 hours postoperatively, bowel function recovery, the incidence of postoperative nausea and vomiting, the incidence of postoperative pulmonary complications, the length of hospital stay, levels of inflammatory factors and patient satisfaction scores.Discussion: This is the first prospective trial to shed light on the efficacy of intraoperative period and 72 postoperative hours intravenous lidocaine on postoperative pain and recovery after hepatectomy. The findings will provide a new strategy of perioperative pain management for hepatectomy.Keywords: intravenous lidocaine, hepatectomy, postoperative pain, recovery
format	article
author	Xu Y Ye M Hong Y Kang Y Li Y Xiao X Zhou L Jiang C
author_facet	Xu Y Ye M Hong Y Kang Y Li Y Xiao X Zhou L Jiang C
author_sort	Xu Y
title	Efficacy of Perioperative Continuous Intravenous Lidocaine Infusion for 72 Hours on Postoperative Pain and Recovery in Patients Undergoing Hepatectomy: Study Protocol for a Prospective Randomized Controlled Trial
title_short	Efficacy of Perioperative Continuous Intravenous Lidocaine Infusion for 72 Hours on Postoperative Pain and Recovery in Patients Undergoing Hepatectomy: Study Protocol for a Prospective Randomized Controlled Trial
title_full	Efficacy of Perioperative Continuous Intravenous Lidocaine Infusion for 72 Hours on Postoperative Pain and Recovery in Patients Undergoing Hepatectomy: Study Protocol for a Prospective Randomized Controlled Trial
title_fullStr	Efficacy of Perioperative Continuous Intravenous Lidocaine Infusion for 72 Hours on Postoperative Pain and Recovery in Patients Undergoing Hepatectomy: Study Protocol for a Prospective Randomized Controlled Trial
title_full_unstemmed	Efficacy of Perioperative Continuous Intravenous Lidocaine Infusion for 72 Hours on Postoperative Pain and Recovery in Patients Undergoing Hepatectomy: Study Protocol for a Prospective Randomized Controlled Trial
title_sort	efficacy of perioperative continuous intravenous lidocaine infusion for 72 hours on postoperative pain and recovery in patients undergoing hepatectomy: study protocol for a prospective randomized controlled trial
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/86db1aa38c8a4ec3a920bd96cd10a248
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Efficacy of Perioperative Continuous Intravenous Lidocaine Infusion for 72 Hours on Postoperative Pain and Recovery in Patients Undergoing Hepatectomy: Study Protocol for a Prospective Randomized Controlled Trial

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