Mesenchymal Stem Cells Anti-Inflammatory Activity in Rats: Proinflammatory Cytokines

Nataliia Petryk, Oleksandr Shevchenko Department of Pathology, Kharkiv National Medical University, Kharkiv, UkraineCorrespondence: Nataliia PetrykDepartment of Pathology, Kharkiv National Medical University, Kharkiv, UkraineEmail perfectgynecologist@gmail.comIntroduction: Many widespread intractabl...

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Autores principales:	Petryk N, Shevchenko O
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	chronic inflammation mesenchymal stem cells carrageenan tumor necrosis factor-alpha interleukin 6 c-reactive protein Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/86dd32cdc4be43d492ba22f1b5224230
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spelling	oai:doaj.org-article:86dd32cdc4be43d492ba22f1b52242302021-12-02T12:55:13ZMesenchymal Stem Cells Anti-Inflammatory Activity in Rats: Proinflammatory Cytokines1178-7031https://doaj.org/article/86dd32cdc4be43d492ba22f1b52242302020-07-01T00:00:00Zhttps://www.dovepress.com/mesenchymal-stem-cells-anti-inflammatory-activity-in-rats-proinflammat-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Nataliia Petryk, Oleksandr Shevchenko Department of Pathology, Kharkiv National Medical University, Kharkiv, UkraineCorrespondence: Nataliia PetrykDepartment of Pathology, Kharkiv National Medical University, Kharkiv, UkraineEmail perfectgynecologist@gmail.comIntroduction: Many widespread intractable diseases are caused or supported by chronic inflammation. Such conditions include the 2nd type of diabetes mellitus, atherosclerosis, neurodegenerative diseases, chronic inflammatory diseases of the connective tissue - ankylosing spondylitis, rheumatoid arthritis, autoimmune myositis, etc. Therefore, the search for targeted treatment of these illnesses is extremely in high demand. Immunomodulatory activity of mesenchymal stem cells is one of their remarkable properties. Several biomarkers (cytokines and nonspecific proteins) are known to be associated with chronic inflammation.Methods: Our study aimed to investigate the serum levels of tumor necrosis factor-alpha, interleukin 6 and C-reactive protein in carrageenan myositis in rats, because there is more and more evidence of the significance of these markers in the course and resolution of the diseases mentioned above. For the first time in our experiment, it was shown and evaluated using analysis of variance, how MSCs influence the indicators of proinflammatory cytokines on the model of carrageenan myositis. The levels of α-TNF, IL-6 and CRP in the plasma of rats were studied in groups with chronic carrageenan inflammation and chronic inflammation with local injection of MSCs into the affected area.Results: Our study proved the effectiveness of MSCs by showing a significant decrease in the levels of inflammatory mediators in the plasma of the studied animals.Discussion and Conclusions: Thus, the administration of MSCs is a promising tool in the pathogenic treatment of chronic inflammation and concomitant conditions.Keywords: chronic inflammation, mesenchymal stem cells, carrageenan, tumor necrosis factor-alpha, interleukin-6, C-reactive proteinPetryk NShevchenko ODove Medical Pressarticlechronic inflammationmesenchymal stem cellscarrageenantumor necrosis factor-alphainterleukin 6c-reactive proteinPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 13, Pp 293-301 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	chronic inflammation mesenchymal stem cells carrageenan tumor necrosis factor-alpha interleukin 6 c-reactive protein Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	chronic inflammation mesenchymal stem cells carrageenan tumor necrosis factor-alpha interleukin 6 c-reactive protein Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Petryk N Shevchenko O Mesenchymal Stem Cells Anti-Inflammatory Activity in Rats: Proinflammatory Cytokines
description	Nataliia Petryk, Oleksandr Shevchenko Department of Pathology, Kharkiv National Medical University, Kharkiv, UkraineCorrespondence: Nataliia PetrykDepartment of Pathology, Kharkiv National Medical University, Kharkiv, UkraineEmail perfectgynecologist@gmail.comIntroduction: Many widespread intractable diseases are caused or supported by chronic inflammation. Such conditions include the 2nd type of diabetes mellitus, atherosclerosis, neurodegenerative diseases, chronic inflammatory diseases of the connective tissue - ankylosing spondylitis, rheumatoid arthritis, autoimmune myositis, etc. Therefore, the search for targeted treatment of these illnesses is extremely in high demand. Immunomodulatory activity of mesenchymal stem cells is one of their remarkable properties. Several biomarkers (cytokines and nonspecific proteins) are known to be associated with chronic inflammation.Methods: Our study aimed to investigate the serum levels of tumor necrosis factor-alpha, interleukin 6 and C-reactive protein in carrageenan myositis in rats, because there is more and more evidence of the significance of these markers in the course and resolution of the diseases mentioned above. For the first time in our experiment, it was shown and evaluated using analysis of variance, how MSCs influence the indicators of proinflammatory cytokines on the model of carrageenan myositis. The levels of α-TNF, IL-6 and CRP in the plasma of rats were studied in groups with chronic carrageenan inflammation and chronic inflammation with local injection of MSCs into the affected area.Results: Our study proved the effectiveness of MSCs by showing a significant decrease in the levels of inflammatory mediators in the plasma of the studied animals.Discussion and Conclusions: Thus, the administration of MSCs is a promising tool in the pathogenic treatment of chronic inflammation and concomitant conditions.Keywords: chronic inflammation, mesenchymal stem cells, carrageenan, tumor necrosis factor-alpha, interleukin-6, C-reactive protein
format	article
author	Petryk N Shevchenko O
author_facet	Petryk N Shevchenko O
author_sort	Petryk N
title	Mesenchymal Stem Cells Anti-Inflammatory Activity in Rats: Proinflammatory Cytokines
title_short	Mesenchymal Stem Cells Anti-Inflammatory Activity in Rats: Proinflammatory Cytokines
title_full	Mesenchymal Stem Cells Anti-Inflammatory Activity in Rats: Proinflammatory Cytokines
title_fullStr	Mesenchymal Stem Cells Anti-Inflammatory Activity in Rats: Proinflammatory Cytokines
title_full_unstemmed	Mesenchymal Stem Cells Anti-Inflammatory Activity in Rats: Proinflammatory Cytokines
title_sort	mesenchymal stem cells anti-inflammatory activity in rats: proinflammatory cytokines
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/86dd32cdc4be43d492ba22f1b5224230
work_keys_str_mv	AT petrykn mesenchymalstemcellsantiinflammatoryactivityinratsproinflammatorycytokines AT shevchenkoo mesenchymalstemcellsantiinflammatoryactivityinratsproinflammatorycytokines
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Mesenchymal Stem Cells Anti-Inflammatory Activity in Rats: Proinflammatory Cytokines

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