Prevalence and factors associated with NAFLD detected by vibration controlled transient elastography among US adults: Results from NHANES 2017-2018.

<h4>Background</h4>Non-alcoholic fatty liver disease (NAFLD) is increasingly common in the adult population. In the United States, the overall burden of NAFLD is unknown due to challenges with population-level NAFLD detection. The purpose of this study was to estimate prevalence of NAFLD...

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Autores principales:	Xiaotao Zhang, Natalia I Heredia, Maya Balakrishnan, Aaron P Thrift
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/86dff6d88ec149e5b5b2fa8d281609ee
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spelling	oai:doaj.org-article:86dff6d88ec149e5b5b2fa8d281609ee2021-12-02T20:03:57ZPrevalence and factors associated with NAFLD detected by vibration controlled transient elastography among US adults: Results from NHANES 2017-2018.1932-620310.1371/journal.pone.0252164https://doaj.org/article/86dff6d88ec149e5b5b2fa8d281609ee2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0252164https://doaj.org/toc/1932-6203<h4>Background</h4>Non-alcoholic fatty liver disease (NAFLD) is increasingly common in the adult population. In the United States, the overall burden of NAFLD is unknown due to challenges with population-level NAFLD detection. The purpose of this study was to estimate prevalence of NAFLD and significant NAFLD fibrosis and identify factors associated with them in the U.S.<h4>Methods</h4>Data came from the 2017-2018 cycle of National Health and Nutrition Examination Survey. We defined NAFLD by controlled attenuation parameter (CAP) scores of ≥248 dB/m in absence of excessive alcohol use and viral hepatitis. We defined significant fibrosis as Vibration controlled transient elastography (VCTE) liver stiffness measurements (LSM) value ≥7.9 kPa. We calculated the adjusted odds ratio (OR) and 95% confidential intervals (CI) for associations with NAFLD and significant NAFLD fibrosis using multivariable logistic regression.<h4>Results</h4>Overall, among 4,024 individuals aged ≥20 years included in the analysis, 56.7% had NAFLD by CAP. In comparison, when defined by elevated liver enzymes, NAFLD prevalence was 12.4%. The prevalence of significant NAFLD fibrosis by VCTE LSM was 14.5%. NAFLD prevalence increased with age, was higher among men than women and among Hispanics compared with non-Hispanic whites. Individuals who were obese, had metabolic syndrome (MetS) and type 2 diabetes were more likely to have NAFLD compared to those that who were not obese or without MetS/diabetes. Inadequate physical activity (OR = 1.57, 95% CI: 1.18-2.08) was also a factor associated with NAFLD. MetS, high waist circumstance, diabetes and hypertension were independently associated with significant NAFLD fibrosis.<h4>Conclusions</h4>NAFLD and significant NAFLD fibrosis are highly prevalent in U.S. general population.Xiaotao ZhangNatalia I HerediaMaya BalakrishnanAaron P ThriftPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0252164 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiaotao Zhang Natalia I Heredia Maya Balakrishnan Aaron P Thrift Prevalence and factors associated with NAFLD detected by vibration controlled transient elastography among US adults: Results from NHANES 2017-2018.
description	<h4>Background</h4>Non-alcoholic fatty liver disease (NAFLD) is increasingly common in the adult population. In the United States, the overall burden of NAFLD is unknown due to challenges with population-level NAFLD detection. The purpose of this study was to estimate prevalence of NAFLD and significant NAFLD fibrosis and identify factors associated with them in the U.S.<h4>Methods</h4>Data came from the 2017-2018 cycle of National Health and Nutrition Examination Survey. We defined NAFLD by controlled attenuation parameter (CAP) scores of ≥248 dB/m in absence of excessive alcohol use and viral hepatitis. We defined significant fibrosis as Vibration controlled transient elastography (VCTE) liver stiffness measurements (LSM) value ≥7.9 kPa. We calculated the adjusted odds ratio (OR) and 95% confidential intervals (CI) for associations with NAFLD and significant NAFLD fibrosis using multivariable logistic regression.<h4>Results</h4>Overall, among 4,024 individuals aged ≥20 years included in the analysis, 56.7% had NAFLD by CAP. In comparison, when defined by elevated liver enzymes, NAFLD prevalence was 12.4%. The prevalence of significant NAFLD fibrosis by VCTE LSM was 14.5%. NAFLD prevalence increased with age, was higher among men than women and among Hispanics compared with non-Hispanic whites. Individuals who were obese, had metabolic syndrome (MetS) and type 2 diabetes were more likely to have NAFLD compared to those that who were not obese or without MetS/diabetes. Inadequate physical activity (OR = 1.57, 95% CI: 1.18-2.08) was also a factor associated with NAFLD. MetS, high waist circumstance, diabetes and hypertension were independently associated with significant NAFLD fibrosis.<h4>Conclusions</h4>NAFLD and significant NAFLD fibrosis are highly prevalent in U.S. general population.
format	article
author	Xiaotao Zhang Natalia I Heredia Maya Balakrishnan Aaron P Thrift
author_facet	Xiaotao Zhang Natalia I Heredia Maya Balakrishnan Aaron P Thrift
author_sort	Xiaotao Zhang
title	Prevalence and factors associated with NAFLD detected by vibration controlled transient elastography among US adults: Results from NHANES 2017-2018.
title_short	Prevalence and factors associated with NAFLD detected by vibration controlled transient elastography among US adults: Results from NHANES 2017-2018.
title_full	Prevalence and factors associated with NAFLD detected by vibration controlled transient elastography among US adults: Results from NHANES 2017-2018.
title_fullStr	Prevalence and factors associated with NAFLD detected by vibration controlled transient elastography among US adults: Results from NHANES 2017-2018.
title_full_unstemmed	Prevalence and factors associated with NAFLD detected by vibration controlled transient elastography among US adults: Results from NHANES 2017-2018.
title_sort	prevalence and factors associated with nafld detected by vibration controlled transient elastography among us adults: results from nhanes 2017-2018.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/86dff6d88ec149e5b5b2fa8d281609ee
work_keys_str_mv	AT xiaotaozhang prevalenceandfactorsassociatedwithnaflddetectedbyvibrationcontrolledtransientelastographyamongusadultsresultsfromnhanes20172018 AT nataliaiheredia prevalenceandfactorsassociatedwithnaflddetectedbyvibrationcontrolledtransientelastographyamongusadultsresultsfromnhanes20172018 AT mayabalakrishnan prevalenceandfactorsassociatedwithnaflddetectedbyvibrationcontrolledtransientelastographyamongusadultsresultsfromnhanes20172018 AT aaronpthrift prevalenceandfactorsassociatedwithnaflddetectedbyvibrationcontrolledtransientelastographyamongusadultsresultsfromnhanes20172018
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Prevalence and factors associated with NAFLD detected by vibration controlled transient elastography among US adults: Results from NHANES 2017-2018.

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