There Is Strength in Numbers: Quantitation of Fc Gamma Receptors on Murine Tissue-Resident Macrophages

Many of the effector functions of antibodies rely on the binding of antibodies/immune complexes to cellular Fcγ receptors (FcγRs). Since the majority of innate immune effector cells express both activating and inhibitory Fc receptors, the outcome of the binding of immune complexes to cells of a give...

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Autores principales:	Christof Vorsatz, Niklas Friedrich, Falk Nimmerjahn, Markus Biburger
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Fc receptors antibodies macrophages alveolar macrophages interstitial macrophages Kupffer cells Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/86e1648055f24213a6d13ac17a314eac
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spelling	oai:doaj.org-article:86e1648055f24213a6d13ac17a314eac2021-11-25T17:53:58ZThere Is Strength in Numbers: Quantitation of Fc Gamma Receptors on Murine Tissue-Resident Macrophages10.3390/ijms2222121721422-00671661-6596https://doaj.org/article/86e1648055f24213a6d13ac17a314eac2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12172https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Many of the effector functions of antibodies rely on the binding of antibodies/immune complexes to cellular Fcγ receptors (FcγRs). Since the majority of innate immune effector cells express both activating and inhibitory Fc receptors, the outcome of the binding of immune complexes to cells of a given population is influenced by the relative affinities of the respective IgG subclasses to these receptors, as well as by the numbers of activating and inhibitory FcγRs on the cell surface. A group of immune cells that has come into focus more recently is the various subsets of tissue-resident macrophages. The central functions of FcγRs on tissue macrophages include the clearance of opsonized pathogens, the removal of small immune complexes from the circulation and the depletion of antibody-opsonized cells in the therapy of autoimmunity and cancer. Despite these essential functions of FcγRs on tissue-resident macrophages, an in-depth quantification of FcγRs is lacking. Thus, the aim of our current study was to quantify the various Fcγ receptors on macrophages in murine liver, lung, kidney, brain, skin and spleen. Our study identified a pronounced heterogeneity between FcγR expression patterns of the different tissue macrophages, which may reflect their specialized functions within their unique niches in different organ environments.Christof VorsatzNiklas FriedrichFalk NimmerjahnMarkus BiburgerMDPI AGarticleFc receptorsantibodiesmacrophagesalveolar macrophagesinterstitial macrophagesKupffer cellsBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12172, p 12172 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Fc receptors antibodies macrophages alveolar macrophages interstitial macrophages Kupffer cells Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	Fc receptors antibodies macrophages alveolar macrophages interstitial macrophages Kupffer cells Biology (General) QH301-705.5 Chemistry QD1-999 Christof Vorsatz Niklas Friedrich Falk Nimmerjahn Markus Biburger There Is Strength in Numbers: Quantitation of Fc Gamma Receptors on Murine Tissue-Resident Macrophages
description	Many of the effector functions of antibodies rely on the binding of antibodies/immune complexes to cellular Fcγ receptors (FcγRs). Since the majority of innate immune effector cells express both activating and inhibitory Fc receptors, the outcome of the binding of immune complexes to cells of a given population is influenced by the relative affinities of the respective IgG subclasses to these receptors, as well as by the numbers of activating and inhibitory FcγRs on the cell surface. A group of immune cells that has come into focus more recently is the various subsets of tissue-resident macrophages. The central functions of FcγRs on tissue macrophages include the clearance of opsonized pathogens, the removal of small immune complexes from the circulation and the depletion of antibody-opsonized cells in the therapy of autoimmunity and cancer. Despite these essential functions of FcγRs on tissue-resident macrophages, an in-depth quantification of FcγRs is lacking. Thus, the aim of our current study was to quantify the various Fcγ receptors on macrophages in murine liver, lung, kidney, brain, skin and spleen. Our study identified a pronounced heterogeneity between FcγR expression patterns of the different tissue macrophages, which may reflect their specialized functions within their unique niches in different organ environments.
format	article
author	Christof Vorsatz Niklas Friedrich Falk Nimmerjahn Markus Biburger
author_facet	Christof Vorsatz Niklas Friedrich Falk Nimmerjahn Markus Biburger
author_sort	Christof Vorsatz
title	There Is Strength in Numbers: Quantitation of Fc Gamma Receptors on Murine Tissue-Resident Macrophages
title_short	There Is Strength in Numbers: Quantitation of Fc Gamma Receptors on Murine Tissue-Resident Macrophages
title_full	There Is Strength in Numbers: Quantitation of Fc Gamma Receptors on Murine Tissue-Resident Macrophages
title_fullStr	There Is Strength in Numbers: Quantitation of Fc Gamma Receptors on Murine Tissue-Resident Macrophages
title_full_unstemmed	There Is Strength in Numbers: Quantitation of Fc Gamma Receptors on Murine Tissue-Resident Macrophages
title_sort	there is strength in numbers: quantitation of fc gamma receptors on murine tissue-resident macrophages
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/86e1648055f24213a6d13ac17a314eac
work_keys_str_mv	AT christofvorsatz thereisstrengthinnumbersquantitationoffcgammareceptorsonmurinetissueresidentmacrophages AT niklasfriedrich thereisstrengthinnumbersquantitationoffcgammareceptorsonmurinetissueresidentmacrophages AT falknimmerjahn thereisstrengthinnumbersquantitationoffcgammareceptorsonmurinetissueresidentmacrophages AT markusbiburger thereisstrengthinnumbersquantitationoffcgammareceptorsonmurinetissueresidentmacrophages
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There Is Strength in Numbers: Quantitation of Fc Gamma Receptors on Murine Tissue-Resident Macrophages

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