Alternations of interhemispheric functional connectivity in children with strabismus and amblyopia: a resting-state fMRI study

Abstract Previous neuroimaging studies demonstrated that patients with strabismus or amblyopia can show significant functional and anatomical changes in the brain, but alterations of interhemispheric functional connectivity (FC) have not been well studied in this population. The current study analyz...

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Autores principales:	Jiaxin Peng, Fan Yao, Qiuyu Li, Qianmin Ge, Wenqing Shi, Ting Su, Liying Tang, Yicong Pan, Rongbin Liang, Lijuan Zhang, Yi Shao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/86ec2aef5f1f48e99f50fcf173bb340f
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spelling	oai:doaj.org-article:86ec2aef5f1f48e99f50fcf173bb340f2021-12-02T16:26:29ZAlternations of interhemispheric functional connectivity in children with strabismus and amblyopia: a resting-state fMRI study10.1038/s41598-021-92281-12045-2322https://doaj.org/article/86ec2aef5f1f48e99f50fcf173bb340f2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92281-1https://doaj.org/toc/2045-2322Abstract Previous neuroimaging studies demonstrated that patients with strabismus or amblyopia can show significant functional and anatomical changes in the brain, but alterations of interhemispheric functional connectivity (FC) have not been well studied in this population. The current study analyzed whole-brain changes of interhemispheric FC in children with strabismus and amblyopia (CSA) using voxel-mirrored homotopic connectivity (VMHC).A total of 24 CSA (16 males and 8 females) and 24 normal controls (NCs) consisting of 16 and 8 age-, sex, and education-matched males and females, respectively, underwent functional magnetic resonance imaging (fMRI) scans in the resting state. According to Gaussian random field theory, changes in the resting state FC (rsFC) between hemispheres were evaluated using the VMHC method. The relationships between mean VMHC values in multiple brain regions and behavioral performance were evaluated by Pearson correlation analysis. In contrast to NCs, the CSA group showed significantly decreased VMHC values in the bilateral cerebellum, bilateral frontal superior orbital (frontal sup orb), bilateral temporal inferior(temporal inf),and bilateral frontal superior(frontal sup). CSA have abnormal interhemispheric FC in many brain regions, which may reflect dysfunction of eye movements and visual fusion. These findings might provide insight into the underlying pathogenetic mechanisms of CSA.Jiaxin PengFan YaoQiuyu LiQianmin GeWenqing ShiTing SuLiying TangYicong PanRongbin LiangLijuan ZhangYi ShaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jiaxin Peng Fan Yao Qiuyu Li Qianmin Ge Wenqing Shi Ting Su Liying Tang Yicong Pan Rongbin Liang Lijuan Zhang Yi Shao Alternations of interhemispheric functional connectivity in children with strabismus and amblyopia: a resting-state fMRI study
description	Abstract Previous neuroimaging studies demonstrated that patients with strabismus or amblyopia can show significant functional and anatomical changes in the brain, but alterations of interhemispheric functional connectivity (FC) have not been well studied in this population. The current study analyzed whole-brain changes of interhemispheric FC in children with strabismus and amblyopia (CSA) using voxel-mirrored homotopic connectivity (VMHC).A total of 24 CSA (16 males and 8 females) and 24 normal controls (NCs) consisting of 16 and 8 age-, sex, and education-matched males and females, respectively, underwent functional magnetic resonance imaging (fMRI) scans in the resting state. According to Gaussian random field theory, changes in the resting state FC (rsFC) between hemispheres were evaluated using the VMHC method. The relationships between mean VMHC values in multiple brain regions and behavioral performance were evaluated by Pearson correlation analysis. In contrast to NCs, the CSA group showed significantly decreased VMHC values in the bilateral cerebellum, bilateral frontal superior orbital (frontal sup orb), bilateral temporal inferior(temporal inf),and bilateral frontal superior(frontal sup). CSA have abnormal interhemispheric FC in many brain regions, which may reflect dysfunction of eye movements and visual fusion. These findings might provide insight into the underlying pathogenetic mechanisms of CSA.
format	article
author	Jiaxin Peng Fan Yao Qiuyu Li Qianmin Ge Wenqing Shi Ting Su Liying Tang Yicong Pan Rongbin Liang Lijuan Zhang Yi Shao
author_facet	Jiaxin Peng Fan Yao Qiuyu Li Qianmin Ge Wenqing Shi Ting Su Liying Tang Yicong Pan Rongbin Liang Lijuan Zhang Yi Shao
author_sort	Jiaxin Peng
title	Alternations of interhemispheric functional connectivity in children with strabismus and amblyopia: a resting-state fMRI study
title_short	Alternations of interhemispheric functional connectivity in children with strabismus and amblyopia: a resting-state fMRI study
title_full	Alternations of interhemispheric functional connectivity in children with strabismus and amblyopia: a resting-state fMRI study
title_fullStr	Alternations of interhemispheric functional connectivity in children with strabismus and amblyopia: a resting-state fMRI study
title_full_unstemmed	Alternations of interhemispheric functional connectivity in children with strabismus and amblyopia: a resting-state fMRI study
title_sort	alternations of interhemispheric functional connectivity in children with strabismus and amblyopia: a resting-state fmri study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/86ec2aef5f1f48e99f50fcf173bb340f
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Alternations of interhemispheric functional connectivity in children with strabismus and amblyopia: a resting-state fMRI study

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