Thermosensitive nanohydrogel of 5-fluorouracil for head and neck cancer: preparation, characterization and cytotoxicity assay

Chintan Dalwadi, Gayatri Patel Department of Pharmaceutics and Pharmaceutical Technology, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology, Changa, Gujarat, India Abstract: Systemic chemotherapy has been shown to produce side effects. A small fraction of the drug...

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Autores principales:	Dalwadi C, Patel G
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Biodegradable Intra tumor Targeted Drug Delivery Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/86ecfe4fe0574a3c8821abc788f07d65
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spelling	oai:doaj.org-article:86ecfe4fe0574a3c8821abc788f07d652021-12-02T07:08:52ZThermosensitive nanohydrogel of 5-fluorouracil for head and neck cancer: preparation, characterization and cytotoxicity assay1178-2013https://doaj.org/article/86ecfe4fe0574a3c8821abc788f07d652018-03-01T00:00:00Zhttps://www.dovepress.com/thermosensitive-nanohydrogel-of-5-fluorouracil-for-head-and-neck-cance-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Chintan Dalwadi, Gayatri Patel Department of Pharmaceutics and Pharmaceutical Technology, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology, Changa, Gujarat, India Abstract: Systemic chemotherapy has been shown to produce side effects. A small fraction of the drug reaches the tumor site; other healthy organs or normal tissues get affected or damaged due to the nonspecific action of these cytotoxic agents. Furthermore, due to their short period of activity, repeat injections are often required, which can lead to the exacerbation of side effects and inconvenience. To overcome these obstacles, in this study, we developed controlled and targeted intratumoral injection. Hydrogel was prepared by physical cross-linking method; however, nanohydrogel was prepared using tip probe-sonicator method. Our results revealed that biodegradable and thermosensitive 5-fluorouracil-loaded methylcellulose nanohydrogel synthesized by physical cross-linking method may be a beneficial approach in targeting the therapeutic agent to the tumor site. Keywords: biodegradable, intra tumor, targeted drug deliveryDalwadi CPatel GDove Medical PressarticleBiodegradableIntra tumorTargeted Drug DeliveryMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 31-33 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biodegradable Intra tumor Targeted Drug Delivery Medicine (General) R5-920
spellingShingle	Biodegradable Intra tumor Targeted Drug Delivery Medicine (General) R5-920 Dalwadi C Patel G Thermosensitive nanohydrogel of 5-fluorouracil for head and neck cancer: preparation, characterization and cytotoxicity assay
description	Chintan Dalwadi, Gayatri Patel Department of Pharmaceutics and Pharmaceutical Technology, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology, Changa, Gujarat, India Abstract: Systemic chemotherapy has been shown to produce side effects. A small fraction of the drug reaches the tumor site; other healthy organs or normal tissues get affected or damaged due to the nonspecific action of these cytotoxic agents. Furthermore, due to their short period of activity, repeat injections are often required, which can lead to the exacerbation of side effects and inconvenience. To overcome these obstacles, in this study, we developed controlled and targeted intratumoral injection. Hydrogel was prepared by physical cross-linking method; however, nanohydrogel was prepared using tip probe-sonicator method. Our results revealed that biodegradable and thermosensitive 5-fluorouracil-loaded methylcellulose nanohydrogel synthesized by physical cross-linking method may be a beneficial approach in targeting the therapeutic agent to the tumor site. Keywords: biodegradable, intra tumor, targeted drug delivery
format	article
author	Dalwadi C Patel G
author_facet	Dalwadi C Patel G
author_sort	Dalwadi C
title	Thermosensitive nanohydrogel of 5-fluorouracil for head and neck cancer: preparation, characterization and cytotoxicity assay
title_short	Thermosensitive nanohydrogel of 5-fluorouracil for head and neck cancer: preparation, characterization and cytotoxicity assay
title_full	Thermosensitive nanohydrogel of 5-fluorouracil for head and neck cancer: preparation, characterization and cytotoxicity assay
title_fullStr	Thermosensitive nanohydrogel of 5-fluorouracil for head and neck cancer: preparation, characterization and cytotoxicity assay
title_full_unstemmed	Thermosensitive nanohydrogel of 5-fluorouracil for head and neck cancer: preparation, characterization and cytotoxicity assay
title_sort	thermosensitive nanohydrogel of 5-fluorouracil for head and neck cancer: preparation, characterization and cytotoxicity assay
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/86ecfe4fe0574a3c8821abc788f07d65
work_keys_str_mv	AT dalwadic thermosensitivenanohydrogelof5fluorouracilforheadandneckcancerpreparationcharacterizationandcytotoxicityassay AT patelg thermosensitivenanohydrogelof5fluorouracilforheadandneckcancerpreparationcharacterizationandcytotoxicityassay
_version_	1718399582851825664

Thermosensitive nanohydrogel of 5-fluorouracil for head and neck cancer: preparation, characterization and cytotoxicity assay

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