53BP1 can limit sister-chromatid rupture and rearrangements driven by a distinct ultrafine DNA bridging-breakage process

Chromosome instability is associated with cancer formation. Here the authors identify in cultured human cancer cells a non-canonical DNA bridge breakage pathway leading to chromosome missegregation and rearrangements triggered by sister DNA intertwinements, which are limited by 53BP1.

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Autores principales:	Ankana Tiwari, Owen Addis Jones, Kok-Lung Chan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/86ed0002a60649d9aed9d1b084c12758
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spelling	oai:doaj.org-article:86ed0002a60649d9aed9d1b084c127582021-12-02T15:34:07Z53BP1 can limit sister-chromatid rupture and rearrangements driven by a distinct ultrafine DNA bridging-breakage process10.1038/s41467-018-03098-y2041-1723https://doaj.org/article/86ed0002a60649d9aed9d1b084c127582018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03098-yhttps://doaj.org/toc/2041-1723Chromosome instability is associated with cancer formation. Here the authors identify in cultured human cancer cells a non-canonical DNA bridge breakage pathway leading to chromosome missegregation and rearrangements triggered by sister DNA intertwinements, which are limited by 53BP1.Ankana TiwariOwen Addis JonesKok-Lung ChanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ankana Tiwari Owen Addis Jones Kok-Lung Chan 53BP1 can limit sister-chromatid rupture and rearrangements driven by a distinct ultrafine DNA bridging-breakage process
description	Chromosome instability is associated with cancer formation. Here the authors identify in cultured human cancer cells a non-canonical DNA bridge breakage pathway leading to chromosome missegregation and rearrangements triggered by sister DNA intertwinements, which are limited by 53BP1.
format	article
author	Ankana Tiwari Owen Addis Jones Kok-Lung Chan
author_facet	Ankana Tiwari Owen Addis Jones Kok-Lung Chan
author_sort	Ankana Tiwari
title	53BP1 can limit sister-chromatid rupture and rearrangements driven by a distinct ultrafine DNA bridging-breakage process
title_short	53BP1 can limit sister-chromatid rupture and rearrangements driven by a distinct ultrafine DNA bridging-breakage process
title_full	53BP1 can limit sister-chromatid rupture and rearrangements driven by a distinct ultrafine DNA bridging-breakage process
title_fullStr	53BP1 can limit sister-chromatid rupture and rearrangements driven by a distinct ultrafine DNA bridging-breakage process
title_full_unstemmed	53BP1 can limit sister-chromatid rupture and rearrangements driven by a distinct ultrafine DNA bridging-breakage process
title_sort	53bp1 can limit sister-chromatid rupture and rearrangements driven by a distinct ultrafine dna bridging-breakage process
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/86ed0002a60649d9aed9d1b084c12758
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53BP1 can limit sister-chromatid rupture and rearrangements driven by a distinct ultrafine DNA bridging-breakage process

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