Phylogenetic and Evolutionary Analysis Reveals the Recent Dominance of Ciprofloxacin-Resistant <named-content content-type="genus-species">Shigella sonnei</named-content> and Local Persistence of <named-content content-type="genus-species">S. flexneri</named-content> Clones in India

ABSTRACT Shigella is the second leading cause of bacterial diarrhea worldwide. Recently, Shigella sonnei seems to be replacing Shigella flexneri in low- and middle-income countries undergoing economic development. Despite this, studies focusing on these species at the genomic level remain largely un...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Dhiviya Prabaa Muthuirulandi Sethuvel, Ankur Mutreja, Agila Kumari Pragasam, Karthick Vasudevan, Dhivya Murugan, Shalini Anandan, Joy Sarojini Michael, Kamini Walia, Balaji Veeraraghavan
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	antimicrobial resistance multidrug resistance Central Asia III Shigella pangenome Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/86edb54bd8d04e028c0542d555a2ccae
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:86edb54bd8d04e028c0542d555a2ccae
record_format	dspace
spelling	oai:doaj.org-article:86edb54bd8d04e028c0542d555a2ccae2021-11-15T15:30:58ZPhylogenetic and Evolutionary Analysis Reveals the Recent Dominance of Ciprofloxacin-Resistant <named-content content-type="genus-species">Shigella sonnei</named-content> and Local Persistence of <named-content content-type="genus-species">S. flexneri</named-content> Clones in India10.1128/mSphere.00569-202379-5042https://doaj.org/article/86edb54bd8d04e028c0542d555a2ccae2020-10-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00569-20https://doaj.org/toc/2379-5042ABSTRACT Shigella is the second leading cause of bacterial diarrhea worldwide. Recently, Shigella sonnei seems to be replacing Shigella flexneri in low- and middle-income countries undergoing economic development. Despite this, studies focusing on these species at the genomic level remain largely unexplored. Here, we compared the genome sequences of S. flexneri and S. sonnei isolates from India with the publicly available genomes of global strains. Our analysis provides evidence for the long-term persistence of all phylogenetic groups (PGs) of S. flexneri and the recent dominance of the ciprofloxacin-resistant S. sonnei lineage in India. Within S. flexneri PGs, the majority of the study isolates belonged to PG3 within the predominance of serotype 2. For S. sonnei, the current pandemic involves globally distributed multidrug-resistant (MDR) clones that belong to Central Asia lineage III. The presence of such epidemiologically dominant lineages in association with stable antimicrobial resistance (AMR) determinants results in successful survival in the community. IMPORTANCE Shigella is the second leading cause of bacterial diarrhea worldwide. This has been categorized as a priority pathogen among enteric bacteria by the Global Antimicrobial Resistance Surveillance System (GLASS) of the World Health Organization (WHO). Recently, S. sonnei seems to be replacing S. flexneri in low- and middle-income countries undergoing economic development. Antimicrobial resistance in S. flexneri and S. sonnei is a growing international concern, specifically with the international dominance of the multidrug-resistant (MDR) lineage. Genomic studies focusing on S. flexneri and S. sonnei in India remain largely unexplored. This study provides information on the introduction and expansion of drug-resistant Shigella strains in India for the first time by comparing the genome sequences of S. flexneri and S. sonnei isolates from India with the publicly available genomes of global strains. The study discusses the key differences between the two dominant species of Shigella at the genomic level to understand the evolutionary trends and genome dynamics of emerging and existing resistance clones. The present work demonstrates evidence for the long-term persistence of all PGs of S. flexneri and the recent dominance of a ciprofloxacin-resistant S. sonnei lineage in India.Dhiviya Prabaa Muthuirulandi SethuvelAnkur MutrejaAgila Kumari PragasamKarthick VasudevanDhivya MuruganShalini AnandanJoy Sarojini MichaelKamini WaliaBalaji VeeraraghavanAmerican Society for Microbiologyarticleantimicrobial resistancemultidrug resistanceCentral Asia IIIShigellapangenomeMicrobiologyQR1-502ENmSphere, Vol 5, Iss 5 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	antimicrobial resistance multidrug resistance Central Asia III Shigella pangenome Microbiology QR1-502
spellingShingle	antimicrobial resistance multidrug resistance Central Asia III Shigella pangenome Microbiology QR1-502 Dhiviya Prabaa Muthuirulandi Sethuvel Ankur Mutreja Agila Kumari Pragasam Karthick Vasudevan Dhivya Murugan Shalini Anandan Joy Sarojini Michael Kamini Walia Balaji Veeraraghavan Phylogenetic and Evolutionary Analysis Reveals the Recent Dominance of Ciprofloxacin-Resistant <named-content content-type="genus-species">Shigella sonnei</named-content> and Local Persistence of <named-content content-type="genus-species">S. flexneri</named-content> Clones in India
description	ABSTRACT Shigella is the second leading cause of bacterial diarrhea worldwide. Recently, Shigella sonnei seems to be replacing Shigella flexneri in low- and middle-income countries undergoing economic development. Despite this, studies focusing on these species at the genomic level remain largely unexplored. Here, we compared the genome sequences of S. flexneri and S. sonnei isolates from India with the publicly available genomes of global strains. Our analysis provides evidence for the long-term persistence of all phylogenetic groups (PGs) of S. flexneri and the recent dominance of the ciprofloxacin-resistant S. sonnei lineage in India. Within S. flexneri PGs, the majority of the study isolates belonged to PG3 within the predominance of serotype 2. For S. sonnei, the current pandemic involves globally distributed multidrug-resistant (MDR) clones that belong to Central Asia lineage III. The presence of such epidemiologically dominant lineages in association with stable antimicrobial resistance (AMR) determinants results in successful survival in the community. IMPORTANCE Shigella is the second leading cause of bacterial diarrhea worldwide. This has been categorized as a priority pathogen among enteric bacteria by the Global Antimicrobial Resistance Surveillance System (GLASS) of the World Health Organization (WHO). Recently, S. sonnei seems to be replacing S. flexneri in low- and middle-income countries undergoing economic development. Antimicrobial resistance in S. flexneri and S. sonnei is a growing international concern, specifically with the international dominance of the multidrug-resistant (MDR) lineage. Genomic studies focusing on S. flexneri and S. sonnei in India remain largely unexplored. This study provides information on the introduction and expansion of drug-resistant Shigella strains in India for the first time by comparing the genome sequences of S. flexneri and S. sonnei isolates from India with the publicly available genomes of global strains. The study discusses the key differences between the two dominant species of Shigella at the genomic level to understand the evolutionary trends and genome dynamics of emerging and existing resistance clones. The present work demonstrates evidence for the long-term persistence of all PGs of S. flexneri and the recent dominance of a ciprofloxacin-resistant S. sonnei lineage in India.
format	article
author	Dhiviya Prabaa Muthuirulandi Sethuvel Ankur Mutreja Agila Kumari Pragasam Karthick Vasudevan Dhivya Murugan Shalini Anandan Joy Sarojini Michael Kamini Walia Balaji Veeraraghavan
author_facet	Dhiviya Prabaa Muthuirulandi Sethuvel Ankur Mutreja Agila Kumari Pragasam Karthick Vasudevan Dhivya Murugan Shalini Anandan Joy Sarojini Michael Kamini Walia Balaji Veeraraghavan
author_sort	Dhiviya Prabaa Muthuirulandi Sethuvel
title	Phylogenetic and Evolutionary Analysis Reveals the Recent Dominance of Ciprofloxacin-Resistant <named-content content-type="genus-species">Shigella sonnei</named-content> and Local Persistence of <named-content content-type="genus-species">S. flexneri</named-content> Clones in India
title_short	Phylogenetic and Evolutionary Analysis Reveals the Recent Dominance of Ciprofloxacin-Resistant <named-content content-type="genus-species">Shigella sonnei</named-content> and Local Persistence of <named-content content-type="genus-species">S. flexneri</named-content> Clones in India
title_full	Phylogenetic and Evolutionary Analysis Reveals the Recent Dominance of Ciprofloxacin-Resistant <named-content content-type="genus-species">Shigella sonnei</named-content> and Local Persistence of <named-content content-type="genus-species">S. flexneri</named-content> Clones in India
title_fullStr	Phylogenetic and Evolutionary Analysis Reveals the Recent Dominance of Ciprofloxacin-Resistant <named-content content-type="genus-species">Shigella sonnei</named-content> and Local Persistence of <named-content content-type="genus-species">S. flexneri</named-content> Clones in India
title_full_unstemmed	Phylogenetic and Evolutionary Analysis Reveals the Recent Dominance of Ciprofloxacin-Resistant <named-content content-type="genus-species">Shigella sonnei</named-content> and Local Persistence of <named-content content-type="genus-species">S. flexneri</named-content> Clones in India
title_sort	phylogenetic and evolutionary analysis reveals the recent dominance of ciprofloxacin-resistant <named-content content-type="genus-species">shigella sonnei</named-content> and local persistence of <named-content content-type="genus-species">s. flexneri</named-content> clones in india
publisher	American Society for Microbiology
publishDate	2020
url	https://doaj.org/article/86edb54bd8d04e028c0542d555a2ccae
work_keys_str_mv	AT dhiviyaprabaamuthuirulandisethuvel phylogeneticandevolutionaryanalysisrevealstherecentdominanceofciprofloxacinresistantnamedcontentcontenttypegenusspeciesshigellasonneinamedcontentandlocalpersistenceofnamedcontentcontenttypegenusspeciessflexnerinamedcontentclonesinindia AT ankurmutreja phylogeneticandevolutionaryanalysisrevealstherecentdominanceofciprofloxacinresistantnamedcontentcontenttypegenusspeciesshigellasonneinamedcontentandlocalpersistenceofnamedcontentcontenttypegenusspeciessflexnerinamedcontentclonesinindia AT agilakumaripragasam phylogeneticandevolutionaryanalysisrevealstherecentdominanceofciprofloxacinresistantnamedcontentcontenttypegenusspeciesshigellasonneinamedcontentandlocalpersistenceofnamedcontentcontenttypegenusspeciessflexnerinamedcontentclonesinindia AT karthickvasudevan phylogeneticandevolutionaryanalysisrevealstherecentdominanceofciprofloxacinresistantnamedcontentcontenttypegenusspeciesshigellasonneinamedcontentandlocalpersistenceofnamedcontentcontenttypegenusspeciessflexnerinamedcontentclonesinindia AT dhivyamurugan phylogeneticandevolutionaryanalysisrevealstherecentdominanceofciprofloxacinresistantnamedcontentcontenttypegenusspeciesshigellasonneinamedcontentandlocalpersistenceofnamedcontentcontenttypegenusspeciessflexnerinamedcontentclonesinindia AT shalinianandan phylogeneticandevolutionaryanalysisrevealstherecentdominanceofciprofloxacinresistantnamedcontentcontenttypegenusspeciesshigellasonneinamedcontentandlocalpersistenceofnamedcontentcontenttypegenusspeciessflexnerinamedcontentclonesinindia AT joysarojinimichael phylogeneticandevolutionaryanalysisrevealstherecentdominanceofciprofloxacinresistantnamedcontentcontenttypegenusspeciesshigellasonneinamedcontentandlocalpersistenceofnamedcontentcontenttypegenusspeciessflexnerinamedcontentclonesinindia AT kaminiwalia phylogeneticandevolutionaryanalysisrevealstherecentdominanceofciprofloxacinresistantnamedcontentcontenttypegenusspeciesshigellasonneinamedcontentandlocalpersistenceofnamedcontentcontenttypegenusspeciessflexnerinamedcontentclonesinindia AT balajiveeraraghavan phylogeneticandevolutionaryanalysisrevealstherecentdominanceofciprofloxacinresistantnamedcontentcontenttypegenusspeciesshigellasonneinamedcontentandlocalpersistenceofnamedcontentcontenttypegenusspeciessflexnerinamedcontentclonesinindia
_version_	1718427896462180352

Phylogenetic and Evolutionary Analysis Reveals the Recent Dominance of Ciprofloxacin-Resistant <named-content content-type="genus-species">Shigella sonnei</named-content> and Local Persistence of <named-content content-type="genus-species">S. flexneri</named-content> Clones in India

Ejemplares similares