The role of hypoxia-induced long noncoding RNAs (lncRNAs) in tumorigenesis and metastasis

Long noncoding RNAs (lncRNAs) are noncoding RNAs with length greater than 200 nt. The biological roles and mechanisms mediated by lncRNAs have been extensively investigated. Hypoxia is a proven microenvironmental factor that promotes solid tumor metastasis. Epithelial-mesenchymal transition (EMT) is...

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Autores principales:	Pei-Hua Peng, Kai-Wen Hsu, Joseph Chieh-Yu Lai, Kou-Juey Wu
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	lncRNAs Hypoxia Epithelial–mesenchymal transition Metastasis Epigenetics LncRNA RP11-390F4.3 Medicine (General) R5-920 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/86ef44f5776c45a98ea67ef8c448ff89
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id	oai:doaj.org-article:86ef44f5776c45a98ea67ef8c448ff89
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spelling	oai:doaj.org-article:86ef44f5776c45a98ea67ef8c448ff892021-11-28T04:33:11ZThe role of hypoxia-induced long noncoding RNAs (lncRNAs) in tumorigenesis and metastasis2319-417010.1016/j.bj.2021.03.005https://doaj.org/article/86ef44f5776c45a98ea67ef8c448ff892021-10-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2319417021000305https://doaj.org/toc/2319-4170Long noncoding RNAs (lncRNAs) are noncoding RNAs with length greater than 200 nt. The biological roles and mechanisms mediated by lncRNAs have been extensively investigated. Hypoxia is a proven microenvironmental factor that promotes solid tumor metastasis. Epithelial-mesenchymal transition (EMT) is one of the major mechanisms induced by hypoxia to contribute to metastasis. Many lncRNAs have been shown to be induced by hypoxia and their roles have been delineated. In this review, we focus on the hypoxia-inducible lncRNAs that interact with protein/protein complex and chromatin/epigenetic factors, and the mechanisms that contribute to metastasis. The role of a recently discovered lncRNA RP11-390F4.3 in hypoxia-induced EMT is discussed. Whole genome approaches to delineating the association between lncRNAs and histone modifications are discussed. Other topics related to hypoxia-induced tumor progression but require further investigation are also mentioned. The clinical significance and treatment strategy targeted against lncRNAs are discussed. The review aims to identify suitable lncRNA targets that may provide feasible therapeutic venues for hypoxia-involved cancers.Pei-Hua PengKai-Wen HsuJoseph Chieh-Yu LaiKou-Juey WuElsevierarticlelncRNAsHypoxiaEpithelial–mesenchymal transitionMetastasisEpigeneticsLncRNA RP11-390F4.3Medicine (General)R5-920Biology (General)QH301-705.5ENBiomedical Journal, Vol 44, Iss 5, Pp 521-533 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lncRNAs Hypoxia Epithelial–mesenchymal transition Metastasis Epigenetics LncRNA RP11-390F4.3 Medicine (General) R5-920 Biology (General) QH301-705.5
spellingShingle	lncRNAs Hypoxia Epithelial–mesenchymal transition Metastasis Epigenetics LncRNA RP11-390F4.3 Medicine (General) R5-920 Biology (General) QH301-705.5 Pei-Hua Peng Kai-Wen Hsu Joseph Chieh-Yu Lai Kou-Juey Wu The role of hypoxia-induced long noncoding RNAs (lncRNAs) in tumorigenesis and metastasis
description	Long noncoding RNAs (lncRNAs) are noncoding RNAs with length greater than 200 nt. The biological roles and mechanisms mediated by lncRNAs have been extensively investigated. Hypoxia is a proven microenvironmental factor that promotes solid tumor metastasis. Epithelial-mesenchymal transition (EMT) is one of the major mechanisms induced by hypoxia to contribute to metastasis. Many lncRNAs have been shown to be induced by hypoxia and their roles have been delineated. In this review, we focus on the hypoxia-inducible lncRNAs that interact with protein/protein complex and chromatin/epigenetic factors, and the mechanisms that contribute to metastasis. The role of a recently discovered lncRNA RP11-390F4.3 in hypoxia-induced EMT is discussed. Whole genome approaches to delineating the association between lncRNAs and histone modifications are discussed. Other topics related to hypoxia-induced tumor progression but require further investigation are also mentioned. The clinical significance and treatment strategy targeted against lncRNAs are discussed. The review aims to identify suitable lncRNA targets that may provide feasible therapeutic venues for hypoxia-involved cancers.
format	article
author	Pei-Hua Peng Kai-Wen Hsu Joseph Chieh-Yu Lai Kou-Juey Wu
author_facet	Pei-Hua Peng Kai-Wen Hsu Joseph Chieh-Yu Lai Kou-Juey Wu
author_sort	Pei-Hua Peng
title	The role of hypoxia-induced long noncoding RNAs (lncRNAs) in tumorigenesis and metastasis
title_short	The role of hypoxia-induced long noncoding RNAs (lncRNAs) in tumorigenesis and metastasis
title_full	The role of hypoxia-induced long noncoding RNAs (lncRNAs) in tumorigenesis and metastasis
title_fullStr	The role of hypoxia-induced long noncoding RNAs (lncRNAs) in tumorigenesis and metastasis
title_full_unstemmed	The role of hypoxia-induced long noncoding RNAs (lncRNAs) in tumorigenesis and metastasis
title_sort	role of hypoxia-induced long noncoding rnas (lncrnas) in tumorigenesis and metastasis
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/86ef44f5776c45a98ea67ef8c448ff89
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The role of hypoxia-induced long noncoding RNAs (lncRNAs) in tumorigenesis and metastasis

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