Interplay between chromosomal alterations and gene mutations shapes the evolutionary trajectory of clonal hematopoiesis

Patients with solid cancers have high rates of clonal haematopoiesis associated with increased risk of secondary leukemias. Here, by using peripheral blood sequencing data from patients with solid non-hematologic cancer, the authors profile the landscape of mosaic chromosomal alterations and gene mu...

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Autores principales:	Teng Gao, Ryan Ptashkin, Kelly L. Bolton, Maria Sirenko, Christopher Fong, Barbara Spitzer, Kamal Menghrajani, Juan E. Arango Ossa, Yangyu Zhou, Elsa Bernard, Max Levine, Juan S. Medina Martinez, Yanming Zhang, Sebastià Franch-Expósito, Minal Patel, Lior Z. Braunstein, Daniel Kelly, Mariko Yabe, Ryma Benayed, Nicole M. Caltabellotta, John Philip, Ederlinda Paraiso, Simon Mantha, David B. Solit, Luis A. Diaz, Michael F. Berger, Virginia Klimek, Ross L. Levine, Ahmet Zehir, Sean M. Devlin, Elli Papaemmanuil
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/86f1527efcbe4a8c928f5380279e4756
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spelling	oai:doaj.org-article:86f1527efcbe4a8c928f5380279e47562021-12-02T14:11:57ZInterplay between chromosomal alterations and gene mutations shapes the evolutionary trajectory of clonal hematopoiesis10.1038/s41467-020-20565-72041-1723https://doaj.org/article/86f1527efcbe4a8c928f5380279e47562021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20565-7https://doaj.org/toc/2041-1723Patients with solid cancers have high rates of clonal haematopoiesis associated with increased risk of secondary leukemias. Here, by using peripheral blood sequencing data from patients with solid non-hematologic cancer, the authors profile the landscape of mosaic chromosomal alterations and gene mutations, defining patients at high risk of leukemia progression.Teng GaoRyan PtashkinKelly L. BoltonMaria SirenkoChristopher FongBarbara SpitzerKamal MenghrajaniJuan E. Arango OssaYangyu ZhouElsa BernardMax LevineJuan S. Medina MartinezYanming ZhangSebastià Franch-ExpósitoMinal PatelLior Z. BraunsteinDaniel KellyMariko YabeRyma BenayedNicole M. CaltabellottaJohn PhilipEderlinda ParaisoSimon ManthaDavid B. SolitLuis A. DiazMichael F. BergerVirginia KlimekRoss L. LevineAhmet ZehirSean M. DevlinElli PapaemmanuilNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Teng Gao Ryan Ptashkin Kelly L. Bolton Maria Sirenko Christopher Fong Barbara Spitzer Kamal Menghrajani Juan E. Arango Ossa Yangyu Zhou Elsa Bernard Max Levine Juan S. Medina Martinez Yanming Zhang Sebastià Franch-Expósito Minal Patel Lior Z. Braunstein Daniel Kelly Mariko Yabe Ryma Benayed Nicole M. Caltabellotta John Philip Ederlinda Paraiso Simon Mantha David B. Solit Luis A. Diaz Michael F. Berger Virginia Klimek Ross L. Levine Ahmet Zehir Sean M. Devlin Elli Papaemmanuil Interplay between chromosomal alterations and gene mutations shapes the evolutionary trajectory of clonal hematopoiesis
description	Patients with solid cancers have high rates of clonal haematopoiesis associated with increased risk of secondary leukemias. Here, by using peripheral blood sequencing data from patients with solid non-hematologic cancer, the authors profile the landscape of mosaic chromosomal alterations and gene mutations, defining patients at high risk of leukemia progression.
format	article
author	Teng Gao Ryan Ptashkin Kelly L. Bolton Maria Sirenko Christopher Fong Barbara Spitzer Kamal Menghrajani Juan E. Arango Ossa Yangyu Zhou Elsa Bernard Max Levine Juan S. Medina Martinez Yanming Zhang Sebastià Franch-Expósito Minal Patel Lior Z. Braunstein Daniel Kelly Mariko Yabe Ryma Benayed Nicole M. Caltabellotta John Philip Ederlinda Paraiso Simon Mantha David B. Solit Luis A. Diaz Michael F. Berger Virginia Klimek Ross L. Levine Ahmet Zehir Sean M. Devlin Elli Papaemmanuil
author_facet	Teng Gao Ryan Ptashkin Kelly L. Bolton Maria Sirenko Christopher Fong Barbara Spitzer Kamal Menghrajani Juan E. Arango Ossa Yangyu Zhou Elsa Bernard Max Levine Juan S. Medina Martinez Yanming Zhang Sebastià Franch-Expósito Minal Patel Lior Z. Braunstein Daniel Kelly Mariko Yabe Ryma Benayed Nicole M. Caltabellotta John Philip Ederlinda Paraiso Simon Mantha David B. Solit Luis A. Diaz Michael F. Berger Virginia Klimek Ross L. Levine Ahmet Zehir Sean M. Devlin Elli Papaemmanuil
author_sort	Teng Gao
title	Interplay between chromosomal alterations and gene mutations shapes the evolutionary trajectory of clonal hematopoiesis
title_short	Interplay between chromosomal alterations and gene mutations shapes the evolutionary trajectory of clonal hematopoiesis
title_full	Interplay between chromosomal alterations and gene mutations shapes the evolutionary trajectory of clonal hematopoiesis
title_fullStr	Interplay between chromosomal alterations and gene mutations shapes the evolutionary trajectory of clonal hematopoiesis
title_full_unstemmed	Interplay between chromosomal alterations and gene mutations shapes the evolutionary trajectory of clonal hematopoiesis
title_sort	interplay between chromosomal alterations and gene mutations shapes the evolutionary trajectory of clonal hematopoiesis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/86f1527efcbe4a8c928f5380279e4756
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Interplay between chromosomal alterations and gene mutations shapes the evolutionary trajectory of clonal hematopoiesis

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