The RNA-Binding Motif Protein Family in Cancer: Friend or Foe?

The RNA-binding motif (RBM) proteins are a class of RNA-binding proteins named, containing RNA-recognition motifs (RRMs), RNA-binding domains, and ribonucleoprotein motifs. RBM proteins are involved in RNA metabolism, including splicing, transport, translation, and stability. Many studies have found...

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Autores principales:	Zhigang Li, Qingyu Guo, Jiaxin Zhang, Zitong Fu, Yifei Wang, Tianzhen Wang, Jing Tang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	RNA-binding motif protein cancer prognosis tumorigenesis RNA binding protein Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/86f177441d734da8916f4f26ab6d8fa7
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id	oai:doaj.org-article:86f177441d734da8916f4f26ab6d8fa7
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spelling	oai:doaj.org-article:86f177441d734da8916f4f26ab6d8fa72021-11-04T07:01:58ZThe RNA-Binding Motif Protein Family in Cancer: Friend or Foe?2234-943X10.3389/fonc.2021.757135https://doaj.org/article/86f177441d734da8916f4f26ab6d8fa72021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.757135/fullhttps://doaj.org/toc/2234-943XThe RNA-binding motif (RBM) proteins are a class of RNA-binding proteins named, containing RNA-recognition motifs (RRMs), RNA-binding domains, and ribonucleoprotein motifs. RBM proteins are involved in RNA metabolism, including splicing, transport, translation, and stability. Many studies have found that aberrant expression and dysregulated function of RBM proteins family members are closely related to the occurrence and development of cancers. This review summarizes the role of RBM proteins family genes in cancers, including their roles in cancer occurrence and cell proliferation, migration, and apoptosis. It is essential to understand the mechanisms of these proteins in tumorigenesis and development, and to identify new therapeutic targets and prognostic markers.Zhigang LiQingyu GuoJiaxin ZhangZitong FuYifei WangTianzhen WangJing TangFrontiers Media S.A.articleRNA-binding motif proteincancerprognosistumorigenesisRNA binding proteinNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	RNA-binding motif protein cancer prognosis tumorigenesis RNA binding protein Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	RNA-binding motif protein cancer prognosis tumorigenesis RNA binding protein Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Zhigang Li Qingyu Guo Jiaxin Zhang Zitong Fu Yifei Wang Tianzhen Wang Jing Tang The RNA-Binding Motif Protein Family in Cancer: Friend or Foe?
description	The RNA-binding motif (RBM) proteins are a class of RNA-binding proteins named, containing RNA-recognition motifs (RRMs), RNA-binding domains, and ribonucleoprotein motifs. RBM proteins are involved in RNA metabolism, including splicing, transport, translation, and stability. Many studies have found that aberrant expression and dysregulated function of RBM proteins family members are closely related to the occurrence and development of cancers. This review summarizes the role of RBM proteins family genes in cancers, including their roles in cancer occurrence and cell proliferation, migration, and apoptosis. It is essential to understand the mechanisms of these proteins in tumorigenesis and development, and to identify new therapeutic targets and prognostic markers.
format	article
author	Zhigang Li Qingyu Guo Jiaxin Zhang Zitong Fu Yifei Wang Tianzhen Wang Jing Tang
author_facet	Zhigang Li Qingyu Guo Jiaxin Zhang Zitong Fu Yifei Wang Tianzhen Wang Jing Tang
author_sort	Zhigang Li
title	The RNA-Binding Motif Protein Family in Cancer: Friend or Foe?
title_short	The RNA-Binding Motif Protein Family in Cancer: Friend or Foe?
title_full	The RNA-Binding Motif Protein Family in Cancer: Friend or Foe?
title_fullStr	The RNA-Binding Motif Protein Family in Cancer: Friend or Foe?
title_full_unstemmed	The RNA-Binding Motif Protein Family in Cancer: Friend or Foe?
title_sort	rna-binding motif protein family in cancer: friend or foe?
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/86f177441d734da8916f4f26ab6d8fa7
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The RNA-Binding Motif Protein Family in Cancer: Friend or Foe?

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