Biomaterials and Meniscal Lesions: Current Concepts and Future Perspective

Menisci are crucial structures for knee homeostasis. After a meniscal lesion, the golden rule, now, is to save as much meniscus as possible; only the meniscus tissue that is identified as unrepairable should be excised, and meniscal sutures find more and more indications. Several different methods h...

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Autores principales:	Michele D. M. Lombardo, Laura Mangiavini, Giuseppe M. Peretti
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	meniscus biomaterial scaffold polymer bioprinting stem cells Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/86f1e2d7fe494e6ca34df61b9f9f64fe
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spelling	oai:doaj.org-article:86f1e2d7fe494e6ca34df61b9f9f64fe2021-11-25T18:41:28ZBiomaterials and Meniscal Lesions: Current Concepts and Future Perspective10.3390/pharmaceutics131118861999-4923https://doaj.org/article/86f1e2d7fe494e6ca34df61b9f9f64fe2021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1886https://doaj.org/toc/1999-4923Menisci are crucial structures for knee homeostasis. After a meniscal lesion, the golden rule, now, is to save as much meniscus as possible; only the meniscus tissue that is identified as unrepairable should be excised, and meniscal sutures find more and more indications. Several different methods have been proposed to improve meniscal healing. They include very basic techniques, such as needling, abrasion, trephination and gluing, or more complex methods, such as synovial flaps, meniscal wrapping or the application of fibrin clots. Basic research of meniscal substitutes has also become very active in the last decades. The aim of this literature review is to analyze possible therapeutic and surgical options that go beyond traditional meniscal surgery: from scaffolds, which are made of different kind of polymers, such as natural, synthetic or hydrogel components, to new technologies, such as 3-D printing construct or hybrid biomaterials made of scaffolds and specific cells. These recent advances show that there is great interest in the development of new materials for meniscal reconstruction and that, with the development of new biomaterials, there will be the possibility of better management of meniscal injuriesMichele D. M. LombardoLaura MangiaviniGiuseppe M. PerettiMDPI AGarticlemeniscusbiomaterialscaffoldpolymerbioprintingstem cellsPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1886, p 1886 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	meniscus biomaterial scaffold polymer bioprinting stem cells Pharmacy and materia medica RS1-441
spellingShingle	meniscus biomaterial scaffold polymer bioprinting stem cells Pharmacy and materia medica RS1-441 Michele D. M. Lombardo Laura Mangiavini Giuseppe M. Peretti Biomaterials and Meniscal Lesions: Current Concepts and Future Perspective
description	Menisci are crucial structures for knee homeostasis. After a meniscal lesion, the golden rule, now, is to save as much meniscus as possible; only the meniscus tissue that is identified as unrepairable should be excised, and meniscal sutures find more and more indications. Several different methods have been proposed to improve meniscal healing. They include very basic techniques, such as needling, abrasion, trephination and gluing, or more complex methods, such as synovial flaps, meniscal wrapping or the application of fibrin clots. Basic research of meniscal substitutes has also become very active in the last decades. The aim of this literature review is to analyze possible therapeutic and surgical options that go beyond traditional meniscal surgery: from scaffolds, which are made of different kind of polymers, such as natural, synthetic or hydrogel components, to new technologies, such as 3-D printing construct or hybrid biomaterials made of scaffolds and specific cells. These recent advances show that there is great interest in the development of new materials for meniscal reconstruction and that, with the development of new biomaterials, there will be the possibility of better management of meniscal injuries
format	article
author	Michele D. M. Lombardo Laura Mangiavini Giuseppe M. Peretti
author_facet	Michele D. M. Lombardo Laura Mangiavini Giuseppe M. Peretti
author_sort	Michele D. M. Lombardo
title	Biomaterials and Meniscal Lesions: Current Concepts and Future Perspective
title_short	Biomaterials and Meniscal Lesions: Current Concepts and Future Perspective
title_full	Biomaterials and Meniscal Lesions: Current Concepts and Future Perspective
title_fullStr	Biomaterials and Meniscal Lesions: Current Concepts and Future Perspective
title_full_unstemmed	Biomaterials and Meniscal Lesions: Current Concepts and Future Perspective
title_sort	biomaterials and meniscal lesions: current concepts and future perspective
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/86f1e2d7fe494e6ca34df61b9f9f64fe
work_keys_str_mv	AT micheledmlombardo biomaterialsandmeniscallesionscurrentconceptsandfutureperspective AT lauramangiavini biomaterialsandmeniscallesionscurrentconceptsandfutureperspective AT giuseppemperetti biomaterialsandmeniscallesionscurrentconceptsandfutureperspective
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Biomaterials and Meniscal Lesions: Current Concepts and Future Perspective

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