Polymorphisms of the cryptochrome 2 and mitoguardin 2 genes are associated with the variation of lipid-related traits in Duroc pigs

Abstract The genetic factors determining the phenotypic variation of porcine fatness phenotypes are still largely unknown. We investigated whether the polymorphism of eight genes (MIGA2, CRY2, NPAS2, CIART, ARNTL2, PER1, PER2 and PCK1), which display differential expression in the skeletal muscle of...

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Autores principales:	Emilio Mármol-Sánchez, Raquel Quintanilla, Taina F. Cardoso, Jordi Jordana Vidal, Marcel Amills
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/86f5d99e83a54a0a8eddb692f1bcc6af
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spelling	oai:doaj.org-article:86f5d99e83a54a0a8eddb692f1bcc6af2021-12-02T15:08:21ZPolymorphisms of the cryptochrome 2 and mitoguardin 2 genes are associated with the variation of lipid-related traits in Duroc pigs10.1038/s41598-019-45108-z2045-2322https://doaj.org/article/86f5d99e83a54a0a8eddb692f1bcc6af2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-45108-zhttps://doaj.org/toc/2045-2322Abstract The genetic factors determining the phenotypic variation of porcine fatness phenotypes are still largely unknown. We investigated whether the polymorphism of eight genes (MIGA2, CRY2, NPAS2, CIART, ARNTL2, PER1, PER2 and PCK1), which display differential expression in the skeletal muscle of fasted and fed sows, is associated with the variation of lipid and mRNA expression phenotypes in Duroc pigs. The performance of an association analysis with the GEMMA software demonstrated that the rs330779504 SNP in the MIGA2 gene is associated with LDL concentration at 190 days (LDL2, corrected P-value = 0.057). Moreover, the rs320439526 SNP of the CRY2 gene displayed a significant association with stearic acid content in the longissimus dorsi muscle (LD C18:0, corrected P-value = 0.015). Both SNPs were also associated with the mRNA levels of the corresponding genes in the gluteus medius skeletal muscle. From a biological perspective these results are meaningful because MIGA2 protein plays an essential role in mitochondrial fusion, a process tightly connected with the energy status of the cell, while CRY2 is a fundamental component of the circadian clock. However, inclusion of these two SNPs in chromosome-wide association analyses demonstrated that they are not located at the peaks of significance for the two traits under study (LDL2 for rs330779504 and LD C18:0 for rs320439526), thus implying that these two SNPs do not have causal effects.Emilio Mármol-SánchezRaquel QuintanillaTaina F. CardosoJordi Jordana VidalMarcel AmillsNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Emilio Mármol-Sánchez Raquel Quintanilla Taina F. Cardoso Jordi Jordana Vidal Marcel Amills Polymorphisms of the cryptochrome 2 and mitoguardin 2 genes are associated with the variation of lipid-related traits in Duroc pigs
description	Abstract The genetic factors determining the phenotypic variation of porcine fatness phenotypes are still largely unknown. We investigated whether the polymorphism of eight genes (MIGA2, CRY2, NPAS2, CIART, ARNTL2, PER1, PER2 and PCK1), which display differential expression in the skeletal muscle of fasted and fed sows, is associated with the variation of lipid and mRNA expression phenotypes in Duroc pigs. The performance of an association analysis with the GEMMA software demonstrated that the rs330779504 SNP in the MIGA2 gene is associated with LDL concentration at 190 days (LDL2, corrected P-value = 0.057). Moreover, the rs320439526 SNP of the CRY2 gene displayed a significant association with stearic acid content in the longissimus dorsi muscle (LD C18:0, corrected P-value = 0.015). Both SNPs were also associated with the mRNA levels of the corresponding genes in the gluteus medius skeletal muscle. From a biological perspective these results are meaningful because MIGA2 protein plays an essential role in mitochondrial fusion, a process tightly connected with the energy status of the cell, while CRY2 is a fundamental component of the circadian clock. However, inclusion of these two SNPs in chromosome-wide association analyses demonstrated that they are not located at the peaks of significance for the two traits under study (LDL2 for rs330779504 and LD C18:0 for rs320439526), thus implying that these two SNPs do not have causal effects.
format	article
author	Emilio Mármol-Sánchez Raquel Quintanilla Taina F. Cardoso Jordi Jordana Vidal Marcel Amills
author_facet	Emilio Mármol-Sánchez Raquel Quintanilla Taina F. Cardoso Jordi Jordana Vidal Marcel Amills
author_sort	Emilio Mármol-Sánchez
title	Polymorphisms of the cryptochrome 2 and mitoguardin 2 genes are associated with the variation of lipid-related traits in Duroc pigs
title_short	Polymorphisms of the cryptochrome 2 and mitoguardin 2 genes are associated with the variation of lipid-related traits in Duroc pigs
title_full	Polymorphisms of the cryptochrome 2 and mitoguardin 2 genes are associated with the variation of lipid-related traits in Duroc pigs
title_fullStr	Polymorphisms of the cryptochrome 2 and mitoguardin 2 genes are associated with the variation of lipid-related traits in Duroc pigs
title_full_unstemmed	Polymorphisms of the cryptochrome 2 and mitoguardin 2 genes are associated with the variation of lipid-related traits in Duroc pigs
title_sort	polymorphisms of the cryptochrome 2 and mitoguardin 2 genes are associated with the variation of lipid-related traits in duroc pigs
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/86f5d99e83a54a0a8eddb692f1bcc6af
work_keys_str_mv	AT emiliomarmolsanchez polymorphismsofthecryptochrome2andmitoguardin2genesareassociatedwiththevariationoflipidrelatedtraitsindurocpigs AT raquelquintanilla polymorphismsofthecryptochrome2andmitoguardin2genesareassociatedwiththevariationoflipidrelatedtraitsindurocpigs AT tainafcardoso polymorphismsofthecryptochrome2andmitoguardin2genesareassociatedwiththevariationoflipidrelatedtraitsindurocpigs AT jordijordanavidal polymorphismsofthecryptochrome2andmitoguardin2genesareassociatedwiththevariationoflipidrelatedtraitsindurocpigs AT marcelamills polymorphismsofthecryptochrome2andmitoguardin2genesareassociatedwiththevariationoflipidrelatedtraitsindurocpigs
_version_	1718388198504136704

Polymorphisms of the cryptochrome 2 and mitoguardin 2 genes are associated with the variation of lipid-related traits in Duroc pigs

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