The Effect of Probiotics in Stroke Treatment

Objective. We conducted a systematic review and meta-analysis to evaluate the curative effect of probiotics combined with enteral nutrition (EN) in patients with stroke. Methods. We retrieved randomized controlled trials and case-controlled trials on the use of probiotics for stroke treatment from P...

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Autores principales:	Da-Yuan Zhong, Lan Li, Ruo-Meng Ma, Yi-Hui Deng
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Other systems of medicine RZ201-999
Acceso en línea:	https://doaj.org/article/86f7e81543644908bab033a42a67853d
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spelling	oai:doaj.org-article:86f7e81543644908bab033a42a67853d2021-11-08T02:36:05ZThe Effect of Probiotics in Stroke Treatment1741-428810.1155/2021/4877311https://doaj.org/article/86f7e81543644908bab033a42a67853d2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/4877311https://doaj.org/toc/1741-4288Objective. We conducted a systematic review and meta-analysis to evaluate the curative effect of probiotics combined with enteral nutrition (EN) in patients with stroke. Methods. We retrieved randomized controlled trials and case-controlled trials on the use of probiotics for stroke treatment from PubMed, Web of Science, CNKI, Wanfang, and Weipu databases. Retrieval times were from the databases’ inception to November 6, 2020. Two researchers conducted a strict evaluation of the literature quality and extracted the data, which were then entered into RevMan 5.3 for meta-analysis. Results. Twenty-three articles were included, including 1,816 patients. The meta-analysis revealed that probiotics combined with EN did not reduce NIHSS scores of patients with stroke (P>0.05). However, it did shorten hospital stays and bedrest periods (P<0.05). Probiotics combined with EN also improved patients’ nutritional status and increased hemoglobin, albumin, serum total protein, and physical and chemical properties of prealbumin (P<0.05). In terms of relieving inflammation, we found that probiotics combined with EN reduced neither high-sensitivity C-reactive protein nor procalcitonin (P>0.05). However, it did cause a significant reduction in TNF-α, IL-6, and IL-10. Probiotics combined with EN significantly reduced esophageal reflux, bloating, constipation, diarrhea, gastric retention, and gastrointestinal bleeding. It relieved intestinal stress and reduced the occurrence of adverse reactions such as esophageal reflux, bloating, constipation, diarrhea, gastric retention, and gastrointestinal bleeding (P<0.05). In terms of reducing stroke complications, probiotics combined with EN reduced the incidence of lung, gastrointestinal, and urinary tract infections (P<0.05). It also reduced fatality rates and intestinal flora imbalance rates (P<0.05). Conclusion. The probiotics combined with EN group’s therapeutic effects were superior to those of the EN alone. Thus, probiotics combined with EN is worthy of both clinical application and promotion in stroke treatment.Da-Yuan ZhongLan LiRuo-Meng MaYi-Hui DengHindawi LimitedarticleOther systems of medicineRZ201-999ENEvidence-Based Complementary and Alternative Medicine, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Other systems of medicine RZ201-999
spellingShingle	Other systems of medicine RZ201-999 Da-Yuan Zhong Lan Li Ruo-Meng Ma Yi-Hui Deng The Effect of Probiotics in Stroke Treatment
description	Objective. We conducted a systematic review and meta-analysis to evaluate the curative effect of probiotics combined with enteral nutrition (EN) in patients with stroke. Methods. We retrieved randomized controlled trials and case-controlled trials on the use of probiotics for stroke treatment from PubMed, Web of Science, CNKI, Wanfang, and Weipu databases. Retrieval times were from the databases’ inception to November 6, 2020. Two researchers conducted a strict evaluation of the literature quality and extracted the data, which were then entered into RevMan 5.3 for meta-analysis. Results. Twenty-three articles were included, including 1,816 patients. The meta-analysis revealed that probiotics combined with EN did not reduce NIHSS scores of patients with stroke (P>0.05). However, it did shorten hospital stays and bedrest periods (P<0.05). Probiotics combined with EN also improved patients’ nutritional status and increased hemoglobin, albumin, serum total protein, and physical and chemical properties of prealbumin (P<0.05). In terms of relieving inflammation, we found that probiotics combined with EN reduced neither high-sensitivity C-reactive protein nor procalcitonin (P>0.05). However, it did cause a significant reduction in TNF-α, IL-6, and IL-10. Probiotics combined with EN significantly reduced esophageal reflux, bloating, constipation, diarrhea, gastric retention, and gastrointestinal bleeding. It relieved intestinal stress and reduced the occurrence of adverse reactions such as esophageal reflux, bloating, constipation, diarrhea, gastric retention, and gastrointestinal bleeding (P<0.05). In terms of reducing stroke complications, probiotics combined with EN reduced the incidence of lung, gastrointestinal, and urinary tract infections (P<0.05). It also reduced fatality rates and intestinal flora imbalance rates (P<0.05). Conclusion. The probiotics combined with EN group’s therapeutic effects were superior to those of the EN alone. Thus, probiotics combined with EN is worthy of both clinical application and promotion in stroke treatment.
format	article
author	Da-Yuan Zhong Lan Li Ruo-Meng Ma Yi-Hui Deng
author_facet	Da-Yuan Zhong Lan Li Ruo-Meng Ma Yi-Hui Deng
author_sort	Da-Yuan Zhong
title	The Effect of Probiotics in Stroke Treatment
title_short	The Effect of Probiotics in Stroke Treatment
title_full	The Effect of Probiotics in Stroke Treatment
title_fullStr	The Effect of Probiotics in Stroke Treatment
title_full_unstemmed	The Effect of Probiotics in Stroke Treatment
title_sort	effect of probiotics in stroke treatment
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/86f7e81543644908bab033a42a67853d
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The Effect of Probiotics in Stroke Treatment

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