Biocompatible nanocarriers that respond to oxidative environments via interactions between chitosan and multiple metal ions

Shichang Zhang, Liye Xia, Chenchen Ding, Lu Wen, Weihua Wan, Gang Chen Department of Pharmaceutics, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China Abstract: Hydrogen peroxide (H2O2) functions as an early damage signal contributing to the oxidative stress respo...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zhang S, Xia L, Ding C, Wen L, Wan W, Chen G
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Oxidation-responsive system Chitosan Nanoparticles Hydrogen peroxide Metal complexes Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/86f8eb99a0d0461d9f175278c4d34267
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:86f8eb99a0d0461d9f175278c4d34267
record_format	dspace
spelling	oai:doaj.org-article:86f8eb99a0d0461d9f175278c4d342672021-12-02T00:30:22ZBiocompatible nanocarriers that respond to oxidative environments via interactions between chitosan and multiple metal ions1178-2013https://doaj.org/article/86f8eb99a0d0461d9f175278c4d342672016-06-01T00:00:00Zhttps://www.dovepress.com/biocompatible-nanocarriers-that-respond-to-oxidative-environments-via--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Shichang Zhang, Liye Xia, Chenchen Ding, Lu Wen, Weihua Wan, Gang Chen Department of Pharmaceutics, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China Abstract: Hydrogen peroxide (H2O2) functions as an early damage signal contributing to the oxidative stress response and can act as a trigger in smart oxidation-responsive drug delivery systems that are currently in development. Current H2O2-triggered oxidation-responsive polymeric systems are usually derived from chemical synthesis and rarely include natural polymers. Herein, we report two series of nanoparticle (NP) complexes prepared with the biopolymer chitosan (CS) and four different metal ions (Cu2+, Ca2+, Zn2+, and Fe3+), defined as CSNPs-metal complexes (Series 1) and CS-metal complexes NPs (Series 2), which responded to oxidation by dissolving upon H2O2 exposure. Experiments examining Nile red release and H2O2-triggered degradation confirmed that both series of complexes showed better sensitivity to oxidation than the CSNPs alone. Furthermore, preliminary cytotoxicity and histological observations indicated that the two series exhibited little or no cytotoxicity and generated a mild inflammatory response. Our work provides a novel and promising strategy for developing NPs for use as intelligent oxidation-responsive systems. Keywords: oxidation-responsive system, chitosan, nanoparticles, hydrogen peroxide, metal complexesZhang SXia LDing CWen LWan WChen GDove Medical PressarticleOxidation-responsive systemChitosanNanoparticlesHydrogen peroxideMetal complexesMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss default, Pp 2769-2784 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Oxidation-responsive system Chitosan Nanoparticles Hydrogen peroxide Metal complexes Medicine (General) R5-920
spellingShingle	Oxidation-responsive system Chitosan Nanoparticles Hydrogen peroxide Metal complexes Medicine (General) R5-920 Zhang S Xia L Ding C Wen L Wan W Chen G Biocompatible nanocarriers that respond to oxidative environments via interactions between chitosan and multiple metal ions
description	Shichang Zhang, Liye Xia, Chenchen Ding, Lu Wen, Weihua Wan, Gang Chen Department of Pharmaceutics, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China Abstract: Hydrogen peroxide (H2O2) functions as an early damage signal contributing to the oxidative stress response and can act as a trigger in smart oxidation-responsive drug delivery systems that are currently in development. Current H2O2-triggered oxidation-responsive polymeric systems are usually derived from chemical synthesis and rarely include natural polymers. Herein, we report two series of nanoparticle (NP) complexes prepared with the biopolymer chitosan (CS) and four different metal ions (Cu2+, Ca2+, Zn2+, and Fe3+), defined as CSNPs-metal complexes (Series 1) and CS-metal complexes NPs (Series 2), which responded to oxidation by dissolving upon H2O2 exposure. Experiments examining Nile red release and H2O2-triggered degradation confirmed that both series of complexes showed better sensitivity to oxidation than the CSNPs alone. Furthermore, preliminary cytotoxicity and histological observations indicated that the two series exhibited little or no cytotoxicity and generated a mild inflammatory response. Our work provides a novel and promising strategy for developing NPs for use as intelligent oxidation-responsive systems. Keywords: oxidation-responsive system, chitosan, nanoparticles, hydrogen peroxide, metal complexes
format	article
author	Zhang S Xia L Ding C Wen L Wan W Chen G
author_facet	Zhang S Xia L Ding C Wen L Wan W Chen G
author_sort	Zhang S
title	Biocompatible nanocarriers that respond to oxidative environments via interactions between chitosan and multiple metal ions
title_short	Biocompatible nanocarriers that respond to oxidative environments via interactions between chitosan and multiple metal ions
title_full	Biocompatible nanocarriers that respond to oxidative environments via interactions between chitosan and multiple metal ions
title_fullStr	Biocompatible nanocarriers that respond to oxidative environments via interactions between chitosan and multiple metal ions
title_full_unstemmed	Biocompatible nanocarriers that respond to oxidative environments via interactions between chitosan and multiple metal ions
title_sort	biocompatible nanocarriers that respond to oxidative environments via interactions between chitosan and multiple metal ions
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/86f8eb99a0d0461d9f175278c4d34267
work_keys_str_mv	AT zhangs biocompatiblenanocarriersthatrespondtooxidativeenvironmentsviainteractionsbetweenchitosanandmultiplemetalions AT xial biocompatiblenanocarriersthatrespondtooxidativeenvironmentsviainteractionsbetweenchitosanandmultiplemetalions AT dingc biocompatiblenanocarriersthatrespondtooxidativeenvironmentsviainteractionsbetweenchitosanandmultiplemetalions AT wenl biocompatiblenanocarriersthatrespondtooxidativeenvironmentsviainteractionsbetweenchitosanandmultiplemetalions AT wanw biocompatiblenanocarriersthatrespondtooxidativeenvironmentsviainteractionsbetweenchitosanandmultiplemetalions AT cheng biocompatiblenanocarriersthatrespondtooxidativeenvironmentsviainteractionsbetweenchitosanandmultiplemetalions
_version_	1718403686806323200

Biocompatible nanocarriers that respond to oxidative environments via interactions between chitosan and multiple metal ions

Ejemplares similares