Non-coding RNAs and their bioengineering applications for neurological diseases

Engineering of cellular biomolecules is an emerging landscape presenting creative therapeutic opportunities. Recently, several strategies such as biomimetic materials, drug-releasing scaffolds, stem cells, and dynamic culture systems have been developed to improve specific biological functions, howe...

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Autores principales:	Tuhin Das, Tushar Kanti Das, Anne Khodarkovskaya, Sabyasachi Dash
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	non-coding rna neurological disorder brain function bioengineering non-coding rna therapeutics genetic regulation biomarker Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/86f98868c6e049ffa0772884afa9dac1
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spelling	oai:doaj.org-article:86f98868c6e049ffa0772884afa9dac12021-11-11T14:23:43ZNon-coding RNAs and their bioengineering applications for neurological diseases2165-59792165-598710.1080/21655979.2021.2003667https://doaj.org/article/86f98868c6e049ffa0772884afa9dac12021-11-01T00:00:00Zhttp://dx.doi.org/10.1080/21655979.2021.2003667https://doaj.org/toc/2165-5979https://doaj.org/toc/2165-5987Engineering of cellular biomolecules is an emerging landscape presenting creative therapeutic opportunities. Recently, several strategies such as biomimetic materials, drug-releasing scaffolds, stem cells, and dynamic culture systems have been developed to improve specific biological functions, however, have been confounded with fundamental and technical roadblocks. Rapidly emerging investigations on the bioengineering prospects of mammalian ribonucleic acid (RNA) is expected to result in significant biomedical advances. More specifically, the current trend focuses on devising non-coding (nc) RNAs as therapeutic candidates for complex neurological diseases. Given the pleiotropic and regulatory role, ncRNAs such as microRNAs and long non-coding RNAs are deemed as attractive therapeutic candidates. Currently, the list of non-coding RNAs in mammals is evolving, which presents the plethora of hidden possibilities including their current scope in biomedicine. Herein, we critically review on the emerging repertoire of ncRNAs in neurological diseases such as Alzheimer’s disease, Parkinson’s disease, neuroinflammation and drug abuse disorders. Importantly, we present the advances in engineering of ncRNAs to improve their biocompatibility and therapeutic feasibility as well as provide key insights into the applications of bioengineered non-coding RNAs that are investigated for neurological diseases.Tuhin DasTushar Kanti DasAnne KhodarkovskayaSabyasachi DashTaylor & Francis Grouparticlenon-coding rnaneurological disorderbrain functionbioengineeringnon-coding rna therapeuticsgenetic regulationbiomarkerBiotechnologyTP248.13-248.65ENBioengineered, Vol 0, Iss 0 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	non-coding rna neurological disorder brain function bioengineering non-coding rna therapeutics genetic regulation biomarker Biotechnology TP248.13-248.65
spellingShingle	non-coding rna neurological disorder brain function bioengineering non-coding rna therapeutics genetic regulation biomarker Biotechnology TP248.13-248.65 Tuhin Das Tushar Kanti Das Anne Khodarkovskaya Sabyasachi Dash Non-coding RNAs and their bioengineering applications for neurological diseases
description	Engineering of cellular biomolecules is an emerging landscape presenting creative therapeutic opportunities. Recently, several strategies such as biomimetic materials, drug-releasing scaffolds, stem cells, and dynamic culture systems have been developed to improve specific biological functions, however, have been confounded with fundamental and technical roadblocks. Rapidly emerging investigations on the bioengineering prospects of mammalian ribonucleic acid (RNA) is expected to result in significant biomedical advances. More specifically, the current trend focuses on devising non-coding (nc) RNAs as therapeutic candidates for complex neurological diseases. Given the pleiotropic and regulatory role, ncRNAs such as microRNAs and long non-coding RNAs are deemed as attractive therapeutic candidates. Currently, the list of non-coding RNAs in mammals is evolving, which presents the plethora of hidden possibilities including their current scope in biomedicine. Herein, we critically review on the emerging repertoire of ncRNAs in neurological diseases such as Alzheimer’s disease, Parkinson’s disease, neuroinflammation and drug abuse disorders. Importantly, we present the advances in engineering of ncRNAs to improve their biocompatibility and therapeutic feasibility as well as provide key insights into the applications of bioengineered non-coding RNAs that are investigated for neurological diseases.
format	article
author	Tuhin Das Tushar Kanti Das Anne Khodarkovskaya Sabyasachi Dash
author_facet	Tuhin Das Tushar Kanti Das Anne Khodarkovskaya Sabyasachi Dash
author_sort	Tuhin Das
title	Non-coding RNAs and their bioengineering applications for neurological diseases
title_short	Non-coding RNAs and their bioengineering applications for neurological diseases
title_full	Non-coding RNAs and their bioengineering applications for neurological diseases
title_fullStr	Non-coding RNAs and their bioengineering applications for neurological diseases
title_full_unstemmed	Non-coding RNAs and their bioengineering applications for neurological diseases
title_sort	non-coding rnas and their bioengineering applications for neurological diseases
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/86f98868c6e049ffa0772884afa9dac1
work_keys_str_mv	AT tuhindas noncodingrnasandtheirbioengineeringapplicationsforneurologicaldiseases AT tusharkantidas noncodingrnasandtheirbioengineeringapplicationsforneurologicaldiseases AT annekhodarkovskaya noncodingrnasandtheirbioengineeringapplicationsforneurologicaldiseases AT sabyasachidash noncodingrnasandtheirbioengineeringapplicationsforneurologicaldiseases
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Non-coding RNAs and their bioengineering applications for neurological diseases

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