Development, Characterization, Stability and Bioaccessibility Improvement of 7,8-Dihydroxyflavone Loaded Zein/Sophorolipid/Polysaccharide Ternary Nanoparticles: Comparison of Sodium Alginate and Sodium Carboxymethyl Cellulose

In this study, two polysaccharides [sodium alginate (ALG) and sodium carboxymethyl cellulose (CMC)] were selected to establish zein/sophorolipid/ALG (ALG/S/Z) and zein/sophorolipid/ALG (CMC/S/Z) nanoparticles to encapsulate 7,8-dihydroxyflavone (7,8-DHF), respectively. The results showed that polysa...

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Autores principales:	Yufeng Chen, Jingchong Peng, Yueqi Wang, Daniel Wadhawan, Lijun Wu, Xiaojing Gao, Yi Sun, Guobin Xia
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Zein 7,8-dihydroxyflavone sophorolipid polysaccharide ternary nanoparticles Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/86f9c4e17633428289fdf10b6f2bc1b0
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spelling	oai:doaj.org-article:86f9c4e17633428289fdf10b6f2bc1b02021-11-25T17:33:36ZDevelopment, Characterization, Stability and Bioaccessibility Improvement of 7,8-Dihydroxyflavone Loaded Zein/Sophorolipid/Polysaccharide Ternary Nanoparticles: Comparison of Sodium Alginate and Sodium Carboxymethyl Cellulose10.3390/foods101126292304-8158https://doaj.org/article/86f9c4e17633428289fdf10b6f2bc1b02021-10-01T00:00:00Zhttps://www.mdpi.com/2304-8158/10/11/2629https://doaj.org/toc/2304-8158In this study, two polysaccharides [sodium alginate (ALG) and sodium carboxymethyl cellulose (CMC)] were selected to establish zein/sophorolipid/ALG (ALG/S/Z) and zein/sophorolipid/ALG (CMC/S/Z) nanoparticles to encapsulate 7,8-dihydroxyflavone (7,8-DHF), respectively. The results showed that polysaccharide types significantly affected performance of ternary nanoparticles, including CMC/S/Z possessed lower polydispersity index, particle size and turbidity, but higher zeta potential, encapsulation efficiency and loading capacity compared to ALG/S/Z. Compared to zein/sophorolipid nanoparticles (S/Z), both ALG/S/Z and CMC/S/Z had better stability against low pH (pH 3~4) and high ionic strengths (150~200 mM NaCl). Hydrophobic effects, electrostatic interactions and hydrogen bonding were confirmed in ternary nanoparticles fabrication via Fourier-transform infrared spectroscopy. Circular dichroism revealed that CMC and ALG had no evident impact on secondary structure of zein in S/Z, but changed surface morphology of S/Z as observed by scanning electron microscope. Encapsulated 7,8-DHF exhibited an amorphous state in ternary nanoparticles as detected by X-ray diffraction and differential scanning calorimetry. Furthermore, compared to S/Z, ALG/S/Z, and CMC/S/Z remarkably improved the storage stability and bioaccessibility of 7,8-DHF. CMC/S/Z possessed a greater storage stability for 7,8-DHF, however, ALG/S/Z exhibited a better in vitro bioaccessibility of 7,8-DHF. This research provides a theoretical reference for zein-based delivery system application.Yufeng ChenJingchong PengYueqi WangDaniel WadhawanLijun WuXiaojing GaoYi SunGuobin XiaMDPI AGarticleZein7,8-dihydroxyflavonesophorolipidpolysaccharideternary nanoparticlesChemical technologyTP1-1185ENFoods, Vol 10, Iss 2629, p 2629 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Zein 7,8-dihydroxyflavone sophorolipid polysaccharide ternary nanoparticles Chemical technology TP1-1185
spellingShingle	Zein 7,8-dihydroxyflavone sophorolipid polysaccharide ternary nanoparticles Chemical technology TP1-1185 Yufeng Chen Jingchong Peng Yueqi Wang Daniel Wadhawan Lijun Wu Xiaojing Gao Yi Sun Guobin Xia Development, Characterization, Stability and Bioaccessibility Improvement of 7,8-Dihydroxyflavone Loaded Zein/Sophorolipid/Polysaccharide Ternary Nanoparticles: Comparison of Sodium Alginate and Sodium Carboxymethyl Cellulose
description	In this study, two polysaccharides [sodium alginate (ALG) and sodium carboxymethyl cellulose (CMC)] were selected to establish zein/sophorolipid/ALG (ALG/S/Z) and zein/sophorolipid/ALG (CMC/S/Z) nanoparticles to encapsulate 7,8-dihydroxyflavone (7,8-DHF), respectively. The results showed that polysaccharide types significantly affected performance of ternary nanoparticles, including CMC/S/Z possessed lower polydispersity index, particle size and turbidity, but higher zeta potential, encapsulation efficiency and loading capacity compared to ALG/S/Z. Compared to zein/sophorolipid nanoparticles (S/Z), both ALG/S/Z and CMC/S/Z had better stability against low pH (pH 3~4) and high ionic strengths (150~200 mM NaCl). Hydrophobic effects, electrostatic interactions and hydrogen bonding were confirmed in ternary nanoparticles fabrication via Fourier-transform infrared spectroscopy. Circular dichroism revealed that CMC and ALG had no evident impact on secondary structure of zein in S/Z, but changed surface morphology of S/Z as observed by scanning electron microscope. Encapsulated 7,8-DHF exhibited an amorphous state in ternary nanoparticles as detected by X-ray diffraction and differential scanning calorimetry. Furthermore, compared to S/Z, ALG/S/Z, and CMC/S/Z remarkably improved the storage stability and bioaccessibility of 7,8-DHF. CMC/S/Z possessed a greater storage stability for 7,8-DHF, however, ALG/S/Z exhibited a better in vitro bioaccessibility of 7,8-DHF. This research provides a theoretical reference for zein-based delivery system application.
format	article
author	Yufeng Chen Jingchong Peng Yueqi Wang Daniel Wadhawan Lijun Wu Xiaojing Gao Yi Sun Guobin Xia
author_facet	Yufeng Chen Jingchong Peng Yueqi Wang Daniel Wadhawan Lijun Wu Xiaojing Gao Yi Sun Guobin Xia
author_sort	Yufeng Chen
title	Development, Characterization, Stability and Bioaccessibility Improvement of 7,8-Dihydroxyflavone Loaded Zein/Sophorolipid/Polysaccharide Ternary Nanoparticles: Comparison of Sodium Alginate and Sodium Carboxymethyl Cellulose
title_short	Development, Characterization, Stability and Bioaccessibility Improvement of 7,8-Dihydroxyflavone Loaded Zein/Sophorolipid/Polysaccharide Ternary Nanoparticles: Comparison of Sodium Alginate and Sodium Carboxymethyl Cellulose
title_full	Development, Characterization, Stability and Bioaccessibility Improvement of 7,8-Dihydroxyflavone Loaded Zein/Sophorolipid/Polysaccharide Ternary Nanoparticles: Comparison of Sodium Alginate and Sodium Carboxymethyl Cellulose
title_fullStr	Development, Characterization, Stability and Bioaccessibility Improvement of 7,8-Dihydroxyflavone Loaded Zein/Sophorolipid/Polysaccharide Ternary Nanoparticles: Comparison of Sodium Alginate and Sodium Carboxymethyl Cellulose
title_full_unstemmed	Development, Characterization, Stability and Bioaccessibility Improvement of 7,8-Dihydroxyflavone Loaded Zein/Sophorolipid/Polysaccharide Ternary Nanoparticles: Comparison of Sodium Alginate and Sodium Carboxymethyl Cellulose
title_sort	development, characterization, stability and bioaccessibility improvement of 7,8-dihydroxyflavone loaded zein/sophorolipid/polysaccharide ternary nanoparticles: comparison of sodium alginate and sodium carboxymethyl cellulose
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/86f9c4e17633428289fdf10b6f2bc1b0
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Development, Characterization, Stability and Bioaccessibility Improvement of 7,8-Dihydroxyflavone Loaded Zein/Sophorolipid/Polysaccharide Ternary Nanoparticles: Comparison of Sodium Alginate and Sodium Carboxymethyl Cellulose

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