Transcriptomic profiling of human cardiac cells predicts protein kinase inhibitor-associated cardiotoxicity

Cardiotoxic adverse events associated with kinase inhibitors are a growing concern in clinical oncology. Here the authors use cellular transcriptomic responses of human cardiomyocytes treated with protein kinase inhibitors and the associated drug structural signatures to determine an integrated pred...

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Autores principales:	J. G. Coen van Hasselt, Rayees Rahman, Jens Hansen, Alan Stern, Jaehee V. Shim, Yuguang Xiong, Amanda Pickard, Gomathi Jayaraman, Bin Hu, Milind Mahajan, James M. Gallo, Joseph Goldfarb, Eric A. Sobie, Marc R. Birtwistle, Avner Schlessinger, Evren U. Azeloglu, Ravi Iyengar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/86f9cff8a37243ebb6125f4c841c6732
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spelling	oai:doaj.org-article:86f9cff8a37243ebb6125f4c841c67322021-12-02T18:14:23ZTranscriptomic profiling of human cardiac cells predicts protein kinase inhibitor-associated cardiotoxicity10.1038/s41467-020-18396-72041-1723https://doaj.org/article/86f9cff8a37243ebb6125f4c841c67322020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18396-7https://doaj.org/toc/2041-1723Cardiotoxic adverse events associated with kinase inhibitors are a growing concern in clinical oncology. Here the authors use cellular transcriptomic responses of human cardiomyocytes treated with protein kinase inhibitors and the associated drug structural signatures to determine an integrated predictive signature of cardiotoxicity.J. G. Coen van HasseltRayees RahmanJens HansenAlan SternJaehee V. ShimYuguang XiongAmanda PickardGomathi JayaramanBin HuMilind MahajanJames M. GalloJoseph GoldfarbEric A. SobieMarc R. BirtwistleAvner SchlessingerEvren U. AzelogluRavi IyengarNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q J. G. Coen van Hasselt Rayees Rahman Jens Hansen Alan Stern Jaehee V. Shim Yuguang Xiong Amanda Pickard Gomathi Jayaraman Bin Hu Milind Mahajan James M. Gallo Joseph Goldfarb Eric A. Sobie Marc R. Birtwistle Avner Schlessinger Evren U. Azeloglu Ravi Iyengar Transcriptomic profiling of human cardiac cells predicts protein kinase inhibitor-associated cardiotoxicity
description	Cardiotoxic adverse events associated with kinase inhibitors are a growing concern in clinical oncology. Here the authors use cellular transcriptomic responses of human cardiomyocytes treated with protein kinase inhibitors and the associated drug structural signatures to determine an integrated predictive signature of cardiotoxicity.
format	article
author	J. G. Coen van Hasselt Rayees Rahman Jens Hansen Alan Stern Jaehee V. Shim Yuguang Xiong Amanda Pickard Gomathi Jayaraman Bin Hu Milind Mahajan James M. Gallo Joseph Goldfarb Eric A. Sobie Marc R. Birtwistle Avner Schlessinger Evren U. Azeloglu Ravi Iyengar
author_facet	J. G. Coen van Hasselt Rayees Rahman Jens Hansen Alan Stern Jaehee V. Shim Yuguang Xiong Amanda Pickard Gomathi Jayaraman Bin Hu Milind Mahajan James M. Gallo Joseph Goldfarb Eric A. Sobie Marc R. Birtwistle Avner Schlessinger Evren U. Azeloglu Ravi Iyengar
author_sort	J. G. Coen van Hasselt
title	Transcriptomic profiling of human cardiac cells predicts protein kinase inhibitor-associated cardiotoxicity
title_short	Transcriptomic profiling of human cardiac cells predicts protein kinase inhibitor-associated cardiotoxicity
title_full	Transcriptomic profiling of human cardiac cells predicts protein kinase inhibitor-associated cardiotoxicity
title_fullStr	Transcriptomic profiling of human cardiac cells predicts protein kinase inhibitor-associated cardiotoxicity
title_full_unstemmed	Transcriptomic profiling of human cardiac cells predicts protein kinase inhibitor-associated cardiotoxicity
title_sort	transcriptomic profiling of human cardiac cells predicts protein kinase inhibitor-associated cardiotoxicity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/86f9cff8a37243ebb6125f4c841c6732
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Transcriptomic profiling of human cardiac cells predicts protein kinase inhibitor-associated cardiotoxicity

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