Cancer risk in mothers of men operated for undescended testis.

<h4>Background</h4>Undescended testis, or cryptorchidism, occurs in 2-5% of boys born at term, and by 12 months of age about 1% of all boys have manifest cryptorchidism. Several hormonal substances control this process and disruption of the foetal sex-hormones balance is a potential caus...

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Autores principales:	Hadriano M Lacerda, Lorenzo Richiardi, Andreas Pettersson, Marine Corbin, Franco Merletti, Olof Akre
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/86fa9e28fa33409c8837d8c8a6e0ba8e
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spelling	oai:doaj.org-article:86fa9e28fa33409c8837d8c8a6e0ba8e2021-11-18T07:01:51ZCancer risk in mothers of men operated for undescended testis.1932-620310.1371/journal.pone.0014285https://doaj.org/article/86fa9e28fa33409c8837d8c8a6e0ba8e2010-12-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21170324/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Undescended testis, or cryptorchidism, occurs in 2-5% of boys born at term, and by 12 months of age about 1% of all boys have manifest cryptorchidism. Several hormonal substances control this process and disruption of the foetal sex-hormones balance is a potential cause of undescended testis, however, to a great extent the aetiology of cryptorchidism is unclear.<h4>Methodology</h4>To study risk factors involved in the aetiology of undescended testis, we assessed cancer risk in 15,885 mothers of men operated for undescended testis in Sweden. Women were followed-up for a median period of 23 years during which 811 first primary malignancies occurred. Their cancer incidence was compared with that in the general population estimating standardized incidence ratio (SIR) and corresponding 95% confidence interval (CI).<h4>Principal findings</h4>The overall cancer risk experienced by the mothers of cryptorchid men did not differ significantly from that of the general population (SIR = 0.94; 95% C.I. = 0.88-1.01). Specifically, there was a reduction in ovarian cancer risk (SIR = 0.72; 95% C.I. = 0.51-0.99), while the risk of lung (SIR = 1.38 95% C.I. 1.03-1.81) and biliary tract/liver cancer (SIR: 1.76, 95% CI: 1.03-2.82) were increased.<h4>Conclusions</h4>Although we cannot rule out the role of chance, our data suggest a positive association between undescended testis and maternal lung cancer and a negative association with ovarian cancer, where the first may be partly attributable to smoking and the second to an altered hormonal milieu during pregnancy and thus both exposures may be risk factors for cryptorchidism.Hadriano M LacerdaLorenzo RichiardiAndreas PetterssonMarine CorbinFranco MerlettiOlof AkrePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 12, p e14285 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hadriano M Lacerda Lorenzo Richiardi Andreas Pettersson Marine Corbin Franco Merletti Olof Akre Cancer risk in mothers of men operated for undescended testis.
description	<h4>Background</h4>Undescended testis, or cryptorchidism, occurs in 2-5% of boys born at term, and by 12 months of age about 1% of all boys have manifest cryptorchidism. Several hormonal substances control this process and disruption of the foetal sex-hormones balance is a potential cause of undescended testis, however, to a great extent the aetiology of cryptorchidism is unclear.<h4>Methodology</h4>To study risk factors involved in the aetiology of undescended testis, we assessed cancer risk in 15,885 mothers of men operated for undescended testis in Sweden. Women were followed-up for a median period of 23 years during which 811 first primary malignancies occurred. Their cancer incidence was compared with that in the general population estimating standardized incidence ratio (SIR) and corresponding 95% confidence interval (CI).<h4>Principal findings</h4>The overall cancer risk experienced by the mothers of cryptorchid men did not differ significantly from that of the general population (SIR = 0.94; 95% C.I. = 0.88-1.01). Specifically, there was a reduction in ovarian cancer risk (SIR = 0.72; 95% C.I. = 0.51-0.99), while the risk of lung (SIR = 1.38 95% C.I. 1.03-1.81) and biliary tract/liver cancer (SIR: 1.76, 95% CI: 1.03-2.82) were increased.<h4>Conclusions</h4>Although we cannot rule out the role of chance, our data suggest a positive association between undescended testis and maternal lung cancer and a negative association with ovarian cancer, where the first may be partly attributable to smoking and the second to an altered hormonal milieu during pregnancy and thus both exposures may be risk factors for cryptorchidism.
format	article
author	Hadriano M Lacerda Lorenzo Richiardi Andreas Pettersson Marine Corbin Franco Merletti Olof Akre
author_facet	Hadriano M Lacerda Lorenzo Richiardi Andreas Pettersson Marine Corbin Franco Merletti Olof Akre
author_sort	Hadriano M Lacerda
title	Cancer risk in mothers of men operated for undescended testis.
title_short	Cancer risk in mothers of men operated for undescended testis.
title_full	Cancer risk in mothers of men operated for undescended testis.
title_fullStr	Cancer risk in mothers of men operated for undescended testis.
title_full_unstemmed	Cancer risk in mothers of men operated for undescended testis.
title_sort	cancer risk in mothers of men operated for undescended testis.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/86fa9e28fa33409c8837d8c8a6e0ba8e
work_keys_str_mv	AT hadrianomlacerda cancerriskinmothersofmenoperatedforundescendedtestis AT lorenzorichiardi cancerriskinmothersofmenoperatedforundescendedtestis AT andreaspettersson cancerriskinmothersofmenoperatedforundescendedtestis AT marinecorbin cancerriskinmothersofmenoperatedforundescendedtestis AT francomerletti cancerriskinmothersofmenoperatedforundescendedtestis AT olofakre cancerriskinmothersofmenoperatedforundescendedtestis
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Cancer risk in mothers of men operated for undescended testis.

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