The Global Epidemic of the SARS-CoV-2 Delta Variant, Key Spike Mutations and Immune Escape

During the COVID-19 pandemic, SARS-CoV-2 variants have emerged and spread worldwide. The Delta (B.1.617.2) variant was first reported in India in October 2020 and was classified as a “variant of concern (VOC)” by the WHO on 11 May, 2021. Compared to the wild-type strain, several studies have shown t...

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Autores principales:	Dandan Tian, Yanhong Sun, Jianming Zhou, Qing Ye
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	COVID-19 SARS-CoV-2 variants mutations vaccine immune escape Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/87046eac842d4d09a14f973c6925365a
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spelling	oai:doaj.org-article:87046eac842d4d09a14f973c6925365a2021-12-01T15:40:43ZThe Global Epidemic of the SARS-CoV-2 Delta Variant, Key Spike Mutations and Immune Escape1664-322410.3389/fimmu.2021.751778https://doaj.org/article/87046eac842d4d09a14f973c6925365a2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.751778/fullhttps://doaj.org/toc/1664-3224During the COVID-19 pandemic, SARS-CoV-2 variants have emerged and spread worldwide. The Delta (B.1.617.2) variant was first reported in India in October 2020 and was classified as a “variant of concern (VOC)” by the WHO on 11 May, 2021. Compared to the wild-type strain, several studies have shown that the Delta variant is more transmissible and has higher viral loads in infected samples. COVID-19 patients infected with the Delta variant have a higher risk of hospitalization, intensive care unit (ICU) admission, and mortality. The Delta variant is becoming the dominant strain in many countries around the world. This review summarizes and analyses the biological characteristics of key amino acid mutations, the epidemic characteristics, and the immune escape of the Delta variant. We hope to provide scientific reference for the monitoring and prevention measures of the SARS-CoV-2 Delta variant and the development strategy of a second-generation vaccine.Dandan TianYanhong SunJianming ZhouQing YeFrontiers Media S.A.articleCOVID-19SARS-CoV-2 variantsmutationsvaccineimmune escapeImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 SARS-CoV-2 variants mutations vaccine immune escape Immunologic diseases. Allergy RC581-607
spellingShingle	COVID-19 SARS-CoV-2 variants mutations vaccine immune escape Immunologic diseases. Allergy RC581-607 Dandan Tian Yanhong Sun Jianming Zhou Qing Ye The Global Epidemic of the SARS-CoV-2 Delta Variant, Key Spike Mutations and Immune Escape
description	During the COVID-19 pandemic, SARS-CoV-2 variants have emerged and spread worldwide. The Delta (B.1.617.2) variant was first reported in India in October 2020 and was classified as a “variant of concern (VOC)” by the WHO on 11 May, 2021. Compared to the wild-type strain, several studies have shown that the Delta variant is more transmissible and has higher viral loads in infected samples. COVID-19 patients infected with the Delta variant have a higher risk of hospitalization, intensive care unit (ICU) admission, and mortality. The Delta variant is becoming the dominant strain in many countries around the world. This review summarizes and analyses the biological characteristics of key amino acid mutations, the epidemic characteristics, and the immune escape of the Delta variant. We hope to provide scientific reference for the monitoring and prevention measures of the SARS-CoV-2 Delta variant and the development strategy of a second-generation vaccine.
format	article
author	Dandan Tian Yanhong Sun Jianming Zhou Qing Ye
author_facet	Dandan Tian Yanhong Sun Jianming Zhou Qing Ye
author_sort	Dandan Tian
title	The Global Epidemic of the SARS-CoV-2 Delta Variant, Key Spike Mutations and Immune Escape
title_short	The Global Epidemic of the SARS-CoV-2 Delta Variant, Key Spike Mutations and Immune Escape
title_full	The Global Epidemic of the SARS-CoV-2 Delta Variant, Key Spike Mutations and Immune Escape
title_fullStr	The Global Epidemic of the SARS-CoV-2 Delta Variant, Key Spike Mutations and Immune Escape
title_full_unstemmed	The Global Epidemic of the SARS-CoV-2 Delta Variant, Key Spike Mutations and Immune Escape
title_sort	global epidemic of the sars-cov-2 delta variant, key spike mutations and immune escape
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/87046eac842d4d09a14f973c6925365a
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The Global Epidemic of the SARS-CoV-2 Delta Variant, Key Spike Mutations and Immune Escape

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