Silent information regulator T1 in aqueous humor of patients with cataract

Aki Kondo,1 Mari Goto,2 Tatsuya Mimura,1 Masao Matsubara1 1Department of Ophthalmology, Tokyo Women’s Medical University Medical Center East, 2Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan Purpose: Silent information regulator T1 (SIRT...

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Autores principales: Kondo A, Goto M, Mimura T, Matsubara M
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Lenguaje:EN
Publicado: Dove Medical Press 2016
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Acceso en línea:https://doaj.org/article/87058da494f94913948db826aa1b9341
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spelling oai:doaj.org-article:87058da494f94913948db826aa1b93412021-12-02T05:42:49ZSilent information regulator T1 in aqueous humor of patients with cataract1177-5483https://doaj.org/article/87058da494f94913948db826aa1b93412016-02-01T00:00:00Zhttps://www.dovepress.com/silent-information-regulator-t1-in-aqueous-humor-of-patients-with-cata-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Aki Kondo,1 Mari Goto,2 Tatsuya Mimura,1 Masao Matsubara1 1Department of Ophthalmology, Tokyo Women’s Medical University Medical Center East, 2Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan Purpose: Silent information regulator T1 (SIRT1), a member of the sirtuin family, has a preventive role in various ocular diseases. We evaluated the relations between the aqueous humor level of SIRT1 and age, sex, systemic diseases, the severity of lens opacity, and other factors. Setting: This study was conducted at a university teaching hospital in Tokyo, Japan. Design: This study was designed based on the consecutive case series. Methods: Aqueous humor samples were obtained from 29 eyes of the 21 consecutive patients undergoing surgery for age-related cataract (ARC). SIRT1 levels were determined by enzyme-linked immunosorbent assay. Results: Aqueous humor levels of SIRT1 showed a positive correlation with visual acuity (logarithm of the minimum angle of resolution) and with the severity of nuclear cataract (r=0.32 and 0.30, respectively, P<0.05). However, only visual acuity was correlated with SIRT1 according to the stepwise multiple regression analysis (P<0.05). Conclusion: These findings suggest that SIRT1 may have an effect on the formation of ARC, acting as a defensive factor against ARC. Keywords: SIRT1, sirtuin, cataract surgery, oxidative stress, resveratrol, ocular agingKondo AGoto MMimura TMatsubara MDove Medical PressarticleSilent information regulator T1SIRT1aqueous humorcataractage-related cataractresveratorolOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2016, Iss Issue 1, Pp 307-312 (2016)
institution DOAJ
collection DOAJ
language EN
topic Silent information regulator T1
SIRT1
aqueous humor
cataract
age-related cataract
resveratorol
Ophthalmology
RE1-994
spellingShingle Silent information regulator T1
SIRT1
aqueous humor
cataract
age-related cataract
resveratorol
Ophthalmology
RE1-994
Kondo A
Goto M
Mimura T
Matsubara M
Silent information regulator T1 in aqueous humor of patients with cataract
description Aki Kondo,1 Mari Goto,2 Tatsuya Mimura,1 Masao Matsubara1 1Department of Ophthalmology, Tokyo Women’s Medical University Medical Center East, 2Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan Purpose: Silent information regulator T1 (SIRT1), a member of the sirtuin family, has a preventive role in various ocular diseases. We evaluated the relations between the aqueous humor level of SIRT1 and age, sex, systemic diseases, the severity of lens opacity, and other factors. Setting: This study was conducted at a university teaching hospital in Tokyo, Japan. Design: This study was designed based on the consecutive case series. Methods: Aqueous humor samples were obtained from 29 eyes of the 21 consecutive patients undergoing surgery for age-related cataract (ARC). SIRT1 levels were determined by enzyme-linked immunosorbent assay. Results: Aqueous humor levels of SIRT1 showed a positive correlation with visual acuity (logarithm of the minimum angle of resolution) and with the severity of nuclear cataract (r=0.32 and 0.30, respectively, P<0.05). However, only visual acuity was correlated with SIRT1 according to the stepwise multiple regression analysis (P<0.05). Conclusion: These findings suggest that SIRT1 may have an effect on the formation of ARC, acting as a defensive factor against ARC. Keywords: SIRT1, sirtuin, cataract surgery, oxidative stress, resveratrol, ocular aging
format article
author Kondo A
Goto M
Mimura T
Matsubara M
author_facet Kondo A
Goto M
Mimura T
Matsubara M
author_sort Kondo A
title Silent information regulator T1 in aqueous humor of patients with cataract
title_short Silent information regulator T1 in aqueous humor of patients with cataract
title_full Silent information regulator T1 in aqueous humor of patients with cataract
title_fullStr Silent information regulator T1 in aqueous humor of patients with cataract
title_full_unstemmed Silent information regulator T1 in aqueous humor of patients with cataract
title_sort silent information regulator t1 in aqueous humor of patients with cataract
publisher Dove Medical Press
publishDate 2016
url https://doaj.org/article/87058da494f94913948db826aa1b9341
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AT mimurat silentinformationregulatort1inaqueoushumorofpatientswithcataract
AT matsubaram silentinformationregulatort1inaqueoushumorofpatientswithcataract
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