Silent information regulator T1 in aqueous humor of patients with cataract
Aki Kondo,1 Mari Goto,2 Tatsuya Mimura,1 Masao Matsubara1 1Department of Ophthalmology, Tokyo Women’s Medical University Medical Center East, 2Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan Purpose: Silent information regulator T1 (SIRT...
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Dove Medical Press
2016
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oai:doaj.org-article:87058da494f94913948db826aa1b93412021-12-02T05:42:49ZSilent information regulator T1 in aqueous humor of patients with cataract1177-5483https://doaj.org/article/87058da494f94913948db826aa1b93412016-02-01T00:00:00Zhttps://www.dovepress.com/silent-information-regulator-t1-in-aqueous-humor-of-patients-with-cata-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Aki Kondo,1 Mari Goto,2 Tatsuya Mimura,1 Masao Matsubara1 1Department of Ophthalmology, Tokyo Women’s Medical University Medical Center East, 2Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan Purpose: Silent information regulator T1 (SIRT1), a member of the sirtuin family, has a preventive role in various ocular diseases. We evaluated the relations between the aqueous humor level of SIRT1 and age, sex, systemic diseases, the severity of lens opacity, and other factors. Setting: This study was conducted at a university teaching hospital in Tokyo, Japan. Design: This study was designed based on the consecutive case series. Methods: Aqueous humor samples were obtained from 29 eyes of the 21 consecutive patients undergoing surgery for age-related cataract (ARC). SIRT1 levels were determined by enzyme-linked immunosorbent assay. Results: Aqueous humor levels of SIRT1 showed a positive correlation with visual acuity (logarithm of the minimum angle of resolution) and with the severity of nuclear cataract (r=0.32 and 0.30, respectively, P<0.05). However, only visual acuity was correlated with SIRT1 according to the stepwise multiple regression analysis (P<0.05). Conclusion: These findings suggest that SIRT1 may have an effect on the formation of ARC, acting as a defensive factor against ARC. Keywords: SIRT1, sirtuin, cataract surgery, oxidative stress, resveratrol, ocular agingKondo AGoto MMimura TMatsubara MDove Medical PressarticleSilent information regulator T1SIRT1aqueous humorcataractage-related cataractresveratorolOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2016, Iss Issue 1, Pp 307-312 (2016) |
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Silent information regulator T1 SIRT1 aqueous humor cataract age-related cataract resveratorol Ophthalmology RE1-994 |
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Silent information regulator T1 SIRT1 aqueous humor cataract age-related cataract resveratorol Ophthalmology RE1-994 Kondo A Goto M Mimura T Matsubara M Silent information regulator T1 in aqueous humor of patients with cataract |
description |
Aki Kondo,1 Mari Goto,2 Tatsuya Mimura,1 Masao Matsubara1 1Department of Ophthalmology, Tokyo Women’s Medical University Medical Center East, 2Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan Purpose: Silent information regulator T1 (SIRT1), a member of the sirtuin family, has a preventive role in various ocular diseases. We evaluated the relations between the aqueous humor level of SIRT1 and age, sex, systemic diseases, the severity of lens opacity, and other factors. Setting: This study was conducted at a university teaching hospital in Tokyo, Japan. Design: This study was designed based on the consecutive case series. Methods: Aqueous humor samples were obtained from 29 eyes of the 21 consecutive patients undergoing surgery for age-related cataract (ARC). SIRT1 levels were determined by enzyme-linked immunosorbent assay. Results: Aqueous humor levels of SIRT1 showed a positive correlation with visual acuity (logarithm of the minimum angle of resolution) and with the severity of nuclear cataract (r=0.32 and 0.30, respectively, P<0.05). However, only visual acuity was correlated with SIRT1 according to the stepwise multiple regression analysis (P<0.05). Conclusion: These findings suggest that SIRT1 may have an effect on the formation of ARC, acting as a defensive factor against ARC. Keywords: SIRT1, sirtuin, cataract surgery, oxidative stress, resveratrol, ocular aging |
format |
article |
author |
Kondo A Goto M Mimura T Matsubara M |
author_facet |
Kondo A Goto M Mimura T Matsubara M |
author_sort |
Kondo A |
title |
Silent information regulator T1 in aqueous humor of patients with cataract |
title_short |
Silent information regulator T1 in aqueous humor of patients with cataract |
title_full |
Silent information regulator T1 in aqueous humor of patients with cataract |
title_fullStr |
Silent information regulator T1 in aqueous humor of patients with cataract |
title_full_unstemmed |
Silent information regulator T1 in aqueous humor of patients with cataract |
title_sort |
silent information regulator t1 in aqueous humor of patients with cataract |
publisher |
Dove Medical Press |
publishDate |
2016 |
url |
https://doaj.org/article/87058da494f94913948db826aa1b9341 |
work_keys_str_mv |
AT kondoa silentinformationregulatort1inaqueoushumorofpatientswithcataract AT gotom silentinformationregulatort1inaqueoushumorofpatientswithcataract AT mimurat silentinformationregulatort1inaqueoushumorofpatientswithcataract AT matsubaram silentinformationregulatort1inaqueoushumorofpatientswithcataract |
_version_ |
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