Effect of Ca-P compound formed by hydrothermal treatment on biodegradation and biocompatibility of Mg-3Al-1Zn-1.5Ca alloy; in vitro and in vivo evaluation

Abstract Chemical combinations of Ca-P produced via plasma electrolytic oxidation (PEO) and a hydrothermal treatment were fabricated to improve the initial corrosion resistance and biocompatibility of a biodegradable Mg-3Al-1Zn-1.5Ca alloy. For the formation of an amorphous calcium phosphate composi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yu-Kyoung Kim, Yong-Seok Jang, Young-Hee Lee, Ho-Keun Yi, Tae-Sung Bae, Min-Ho Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/870669ca895842c99ef2c3708d21d423
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:870669ca895842c99ef2c3708d21d423
record_format	dspace
spelling	oai:doaj.org-article:870669ca895842c99ef2c3708d21d4232021-12-02T15:06:12ZEffect of Ca-P compound formed by hydrothermal treatment on biodegradation and biocompatibility of Mg-3Al-1Zn-1.5Ca alloy; in vitro and in vivo evaluation10.1038/s41598-017-00656-02045-2322https://doaj.org/article/870669ca895842c99ef2c3708d21d4232017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00656-0https://doaj.org/toc/2045-2322Abstract Chemical combinations of Ca-P produced via plasma electrolytic oxidation (PEO) and a hydrothermal treatment were fabricated to improve the initial corrosion resistance and biocompatibility of a biodegradable Mg-3Al-1Zn-1.5Ca alloy. For the formation of an amorphous calcium phosphate composite layer on the surface of a magnesium alloy, a PEO layer composed of MgO and Mg3(PO4)2 was formed by PEO in electrolytes containing preliminary phosphate ions. During the second stage, a thick and dense Ca layer was formed by Ca electrodeposition after PEO. Finally, a hydrothermal treatment was carried out for chemical incorporation of P ions in the PEO layer and Ca ions in the electrodeposition layer. The amorphous calcium phosphate composite layer formed by the hydrothermal treatment enhanced osteoblast activity and reduced H2O2 production, which is a known stress indicator for cells. As a result of co-culturing osteoblast cells and RAW 264.7 cells, the formation of amorphous calcium phosphate increased osteoblast cell differentiation and decreased osteoclast cell differentiation. Implanting the alloy, which had an amorphous calcium phosphate composite layer that had been added through hydrothermal treatment, in the tibia of rats led to a reduction in initial biodegradation and promoted new bone formation.Yu-Kyoung KimYong-Seok JangYoung-Hee LeeHo-Keun YiTae-Sung BaeMin-Ho LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yu-Kyoung Kim Yong-Seok Jang Young-Hee Lee Ho-Keun Yi Tae-Sung Bae Min-Ho Lee Effect of Ca-P compound formed by hydrothermal treatment on biodegradation and biocompatibility of Mg-3Al-1Zn-1.5Ca alloy; in vitro and in vivo evaluation
description	Abstract Chemical combinations of Ca-P produced via plasma electrolytic oxidation (PEO) and a hydrothermal treatment were fabricated to improve the initial corrosion resistance and biocompatibility of a biodegradable Mg-3Al-1Zn-1.5Ca alloy. For the formation of an amorphous calcium phosphate composite layer on the surface of a magnesium alloy, a PEO layer composed of MgO and Mg3(PO4)2 was formed by PEO in electrolytes containing preliminary phosphate ions. During the second stage, a thick and dense Ca layer was formed by Ca electrodeposition after PEO. Finally, a hydrothermal treatment was carried out for chemical incorporation of P ions in the PEO layer and Ca ions in the electrodeposition layer. The amorphous calcium phosphate composite layer formed by the hydrothermal treatment enhanced osteoblast activity and reduced H2O2 production, which is a known stress indicator for cells. As a result of co-culturing osteoblast cells and RAW 264.7 cells, the formation of amorphous calcium phosphate increased osteoblast cell differentiation and decreased osteoclast cell differentiation. Implanting the alloy, which had an amorphous calcium phosphate composite layer that had been added through hydrothermal treatment, in the tibia of rats led to a reduction in initial biodegradation and promoted new bone formation.
format	article
author	Yu-Kyoung Kim Yong-Seok Jang Young-Hee Lee Ho-Keun Yi Tae-Sung Bae Min-Ho Lee
author_facet	Yu-Kyoung Kim Yong-Seok Jang Young-Hee Lee Ho-Keun Yi Tae-Sung Bae Min-Ho Lee
author_sort	Yu-Kyoung Kim
title	Effect of Ca-P compound formed by hydrothermal treatment on biodegradation and biocompatibility of Mg-3Al-1Zn-1.5Ca alloy; in vitro and in vivo evaluation
title_short	Effect of Ca-P compound formed by hydrothermal treatment on biodegradation and biocompatibility of Mg-3Al-1Zn-1.5Ca alloy; in vitro and in vivo evaluation
title_full	Effect of Ca-P compound formed by hydrothermal treatment on biodegradation and biocompatibility of Mg-3Al-1Zn-1.5Ca alloy; in vitro and in vivo evaluation
title_fullStr	Effect of Ca-P compound formed by hydrothermal treatment on biodegradation and biocompatibility of Mg-3Al-1Zn-1.5Ca alloy; in vitro and in vivo evaluation
title_full_unstemmed	Effect of Ca-P compound formed by hydrothermal treatment on biodegradation and biocompatibility of Mg-3Al-1Zn-1.5Ca alloy; in vitro and in vivo evaluation
title_sort	effect of ca-p compound formed by hydrothermal treatment on biodegradation and biocompatibility of mg-3al-1zn-1.5ca alloy; in vitro and in vivo evaluation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/870669ca895842c99ef2c3708d21d423
work_keys_str_mv	AT yukyoungkim effectofcapcompoundformedbyhydrothermaltreatmentonbiodegradationandbiocompatibilityofmg3al1zn15caalloyinvitroandinvivoevaluation AT yongseokjang effectofcapcompoundformedbyhydrothermaltreatmentonbiodegradationandbiocompatibilityofmg3al1zn15caalloyinvitroandinvivoevaluation AT youngheelee effectofcapcompoundformedbyhydrothermaltreatmentonbiodegradationandbiocompatibilityofmg3al1zn15caalloyinvitroandinvivoevaluation AT hokeunyi effectofcapcompoundformedbyhydrothermaltreatmentonbiodegradationandbiocompatibilityofmg3al1zn15caalloyinvitroandinvivoevaluation AT taesungbae effectofcapcompoundformedbyhydrothermaltreatmentonbiodegradationandbiocompatibilityofmg3al1zn15caalloyinvitroandinvivoevaluation AT minholee effectofcapcompoundformedbyhydrothermaltreatmentonbiodegradationandbiocompatibilityofmg3al1zn15caalloyinvitroandinvivoevaluation
_version_	1718388595012665344

Effect of Ca-P compound formed by hydrothermal treatment on biodegradation and biocompatibility of Mg-3Al-1Zn-1.5Ca alloy; in vitro and in vivo evaluation

Ejemplares similares