Minimizing nocebo effect: Pragmatic approach

The nocebo effect, the inverse of the placebo effect, is a well-established phenomenon, yet under-appreciated. It refers to nonpharmacological, harmful, or undesirable effects occurring after active or inactive therapy. The frequency of adverse events can dramatically increase by informing patients...

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Autores principales:	Majed Chamsi Pasha, Mohammed Ali Albar, Hassan Chamsi Pasha
Formato:	article
Lenguaje:	EN
Publicado:	Thieme Medical and Scientific Publishers Pvt. Ltd. 2017
Materias:	drugs medical ethics nocebo placebo treatment Medicine R
Acceso en línea:	https://doaj.org/article/8707094e53d34f748d90fa72773c36c9
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spelling	oai:doaj.org-article:8707094e53d34f748d90fa72773c36c92021-12-02T17:05:54ZMinimizing nocebo effect: Pragmatic approach2231-07702249-446410.4103/ajm.AJM_59_17https://doaj.org/article/8707094e53d34f748d90fa72773c36c92017-10-01T00:00:00Zhttp://www.thieme-connect.de/DOI/DOI?10.4103/ajm.AJM_59_17https://doaj.org/toc/2231-0770https://doaj.org/toc/2249-4464The nocebo effect, the inverse of the placebo effect, is a well-established phenomenon, yet under-appreciated. It refers to nonpharmacological, harmful, or undesirable effects occurring after active or inactive therapy. The frequency of adverse events can dramatically increase by informing patients about the possible side effects of the treatment, and by negative expectations on the part of the patient. Patients who were told that they might experience sexual side effects after treatment with β-blocker drugs reported these symptoms between three and four times more often than patients in a control group who were not informed about these symptoms. Nocebo effect has been reported in several neurological diseases such as migraine, epilepsy, multiple sclerosis, Parkinson's disease and neuropathic pain, and in patients with depression. The investigation of the biological and theoretical underpinning of the nocebo phenomenon is at an early stage, and more research is required. Physicians need to be aware of the influence of nocebo phenomenon and be able to recognize it and minimize its effects.Majed Chamsi PashaMohammed Ali AlbarHassan Chamsi PashaThieme Medical and Scientific Publishers Pvt. Ltd.articledrugsmedical ethicsnoceboplacebotreatmentMedicineRENAvicenna Journal of Medicine, Vol 07, Iss 04, Pp 139-143 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	drugs medical ethics nocebo placebo treatment Medicine R
spellingShingle	drugs medical ethics nocebo placebo treatment Medicine R Majed Chamsi Pasha Mohammed Ali Albar Hassan Chamsi Pasha Minimizing nocebo effect: Pragmatic approach
description	The nocebo effect, the inverse of the placebo effect, is a well-established phenomenon, yet under-appreciated. It refers to nonpharmacological, harmful, or undesirable effects occurring after active or inactive therapy. The frequency of adverse events can dramatically increase by informing patients about the possible side effects of the treatment, and by negative expectations on the part of the patient. Patients who were told that they might experience sexual side effects after treatment with β-blocker drugs reported these symptoms between three and four times more often than patients in a control group who were not informed about these symptoms. Nocebo effect has been reported in several neurological diseases such as migraine, epilepsy, multiple sclerosis, Parkinson's disease and neuropathic pain, and in patients with depression. The investigation of the biological and theoretical underpinning of the nocebo phenomenon is at an early stage, and more research is required. Physicians need to be aware of the influence of nocebo phenomenon and be able to recognize it and minimize its effects.
format	article
author	Majed Chamsi Pasha Mohammed Ali Albar Hassan Chamsi Pasha
author_facet	Majed Chamsi Pasha Mohammed Ali Albar Hassan Chamsi Pasha
author_sort	Majed Chamsi Pasha
title	Minimizing nocebo effect: Pragmatic approach
title_short	Minimizing nocebo effect: Pragmatic approach
title_full	Minimizing nocebo effect: Pragmatic approach
title_fullStr	Minimizing nocebo effect: Pragmatic approach
title_full_unstemmed	Minimizing nocebo effect: Pragmatic approach
title_sort	minimizing nocebo effect: pragmatic approach
publisher	Thieme Medical and Scientific Publishers Pvt. Ltd.
publishDate	2017
url	https://doaj.org/article/8707094e53d34f748d90fa72773c36c9
work_keys_str_mv	AT majedchamsipasha minimizingnoceboeffectpragmaticapproach AT mohammedalialbar minimizingnoceboeffectpragmaticapproach AT hassanchamsipasha minimizingnoceboeffectpragmaticapproach
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Minimizing nocebo effect: Pragmatic approach

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