Role of the WASP and WAVE family proteins in breast cancer invasion and metastasis

Bethan Frugtniet, Wen G Jiang, Tracey A Martin Cardiff-China Medical Research Collaborative, Cardiff University School of Medicine, Cardiff University, Cardiff, UKAbstract: The Wiskott–Aldrich syndrome protein (WASP) and WASP family verprolin-homologous protein (WAVE) family are a group of...

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Autores principales:	Frugtniet B, Jiang WG, Martin TA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/870772f740544e57bdea345cd3e622d0
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spelling	oai:doaj.org-article:870772f740544e57bdea345cd3e622d02021-12-02T06:46:12ZRole of the WASP and WAVE family proteins in breast cancer invasion and metastasis1179-1314https://doaj.org/article/870772f740544e57bdea345cd3e622d02015-04-01T00:00:00Zhttp://www.dovepress.com/role-of-the-wasp-and-wave-family-proteins-in-breast-cancer-invasion-an-peer-reviewed-article-BCTThttps://doaj.org/toc/1179-1314Bethan Frugtniet, Wen G Jiang, Tracey A Martin Cardiff-China Medical Research Collaborative, Cardiff University School of Medicine, Cardiff University, Cardiff, UKAbstract: The Wiskott–Aldrich syndrome protein (WASP) and WASP family verprolin-homologous protein (WAVE) family are a group of molecules that form a key link between GTPases and the actin cytoskeleton. The role of WASP/WAVE family proteins in the control of actin polymerization through activation of the actin-related protein 2/3 complex is critical in the formation of the actin-based membrane protrusions seen in cell migration and invasion. For this reason, the activity of the WASP/WAVE family in cancer cell invasion and migration has been of great interest in recent years. Many reports have highlighted the potential of targeting the WASP/WAVE family as a therapy for the prevention of cancer progression, in particular breast cancer. This review focuses on the role of the WASP/WAVE family in breast cancer cell invasion and migration and how this relates to the molecular mechanisms of WASP/WAVE activity, their exact contributions to the stages of cancer progression, and how this can lead to the development of anticancer drugs that target the WASP/WAVE family and related pathways.Keywords: WASP, WAVE, breast cancer, migration, invasionFrugtniet BJiang WGMartin TADove Medical PressarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol 2015, Iss default, Pp 99-109 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Frugtniet B Jiang WG Martin TA Role of the WASP and WAVE family proteins in breast cancer invasion and metastasis
description	Bethan Frugtniet, Wen G Jiang, Tracey A Martin Cardiff-China Medical Research Collaborative, Cardiff University School of Medicine, Cardiff University, Cardiff, UKAbstract: The Wiskott–Aldrich syndrome protein (WASP) and WASP family verprolin-homologous protein (WAVE) family are a group of molecules that form a key link between GTPases and the actin cytoskeleton. The role of WASP/WAVE family proteins in the control of actin polymerization through activation of the actin-related protein 2/3 complex is critical in the formation of the actin-based membrane protrusions seen in cell migration and invasion. For this reason, the activity of the WASP/WAVE family in cancer cell invasion and migration has been of great interest in recent years. Many reports have highlighted the potential of targeting the WASP/WAVE family as a therapy for the prevention of cancer progression, in particular breast cancer. This review focuses on the role of the WASP/WAVE family in breast cancer cell invasion and migration and how this relates to the molecular mechanisms of WASP/WAVE activity, their exact contributions to the stages of cancer progression, and how this can lead to the development of anticancer drugs that target the WASP/WAVE family and related pathways.Keywords: WASP, WAVE, breast cancer, migration, invasion
format	article
author	Frugtniet B Jiang WG Martin TA
author_facet	Frugtniet B Jiang WG Martin TA
author_sort	Frugtniet B
title	Role of the WASP and WAVE family proteins in breast cancer invasion and metastasis
title_short	Role of the WASP and WAVE family proteins in breast cancer invasion and metastasis
title_full	Role of the WASP and WAVE family proteins in breast cancer invasion and metastasis
title_fullStr	Role of the WASP and WAVE family proteins in breast cancer invasion and metastasis
title_full_unstemmed	Role of the WASP and WAVE family proteins in breast cancer invasion and metastasis
title_sort	role of the wasp and wave family proteins in breast cancer invasion and metastasis
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/870772f740544e57bdea345cd3e622d0
work_keys_str_mv	AT frugtnietb roleofthewaspandwavefamilyproteinsinbreastcancerinvasionandmetastasis AT jiangwg roleofthewaspandwavefamilyproteinsinbreastcancerinvasionandmetastasis AT martinta roleofthewaspandwavefamilyproteinsinbreastcancerinvasionandmetastasis
_version_	1718399762792710144

Role of the WASP and WAVE family proteins in breast cancer invasion and metastasis

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